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Protein

Uncharacterized RNA pseudouridine synthase ML1370

Gene

ML1370

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei121 – 1211NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized RNA pseudouridine synthase ML1370 (EC:5.4.99.-)
Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase
Gene namesi
Ordered Locus Names:ML1370
ORF Names:MLCB1351.03c, u0247g
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1370.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Uncharacterized RNA pseudouridine synthase ML1370PRO_0000100028Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1370.

Structurei

3D structure databases

ProteinModelPortaliO05668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 8368S4 RNA-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase RsuA family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105FE9. Bacteria.
COG1187. LUCA.
HOGENOMiHOG000044954.
KOiK06178.
OMAiHAFMANA.
OrthoDBiPOG091H02IO.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
IPR018496. PsdUridine_synth_RsuA/RluB_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00093. TIGR00093. 1 hit.
PROSITEiPS01149. PSI_RSU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O05668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEIHDSRMD RGAGAVRLQK ILSRAGIASR RAAEKLIIEG RVEVDGQLVR
60 70 80 90 100
ELGTRVDPDV SVVRVDGVKV VVDDSLVYLA LNKPRGMYST MSDDRGRPCV
110 120 130 140 150
GDLIERRVRG NKKLFHVGRL DADTEGLILL TNDGELAHRL MHPSHEVSKT
160 170 180 190 200
YLATVKGAVP RGLGKKLSVG LELDDGPAHV DDFAVVDAIP GKTLVRLTLH
210 220 230 240 250
EGRKRIVRRL LTAAGFPVEM LVRTDIGAVS LGDQRPGCLR ALLRDEIRQL

YKEVGL
Length:256
Mass (Da):28,114
Last modified:July 1, 1997 - v1
Checksum:i686746EF490FB695
GO

Sequence cautioni

The sequence CAC31751 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z95117 Genomic DNA. Translation: CAB08276.1.
AL583921 Genomic DNA. Translation: CAC31751.1. Different initiation.
U00021 Genomic DNA. Translation: AAA50926.1.
PIRiD87080.
S72955.
RefSeqiWP_010908299.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31751; CAC31751; CAC31751.
KEGGimle:ML1370.
PATRICi18055186. VBIMycLep78757_2527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z95117 Genomic DNA. Translation: CAB08276.1.
AL583921 Genomic DNA. Translation: CAC31751.1. Different initiation.
U00021 Genomic DNA. Translation: AAA50926.1.
PIRiD87080.
S72955.
RefSeqiWP_010908299.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO05668.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1370.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31751; CAC31751; CAC31751.
KEGGimle:ML1370.
PATRICi18055186. VBIMycLep78757_2527.

Organism-specific databases

LepromaiML1370.

Phylogenomic databases

eggNOGiENOG4105FE9. Bacteria.
COG1187. LUCA.
HOGENOMiHOG000044954.
KOiK06178.
OMAiHAFMANA.
OrthoDBiPOG091H02IO.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
IPR018496. PsdUridine_synth_RsuA/RluB_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00093. TIGR00093. 1 hit.
PROSITEiPS01149. PSI_RSU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiY1370_MYCLE
AccessioniPrimary (citable) accession number: O05668
Secondary accession number(s): Q49886
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.