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Reviewed, UniProtKB/Swiss-Prot O05650 (PORC_THEMA)

Last modified February 9, 2010. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Pyruvate synthase subunit porC
    EC=1.2.7.1
Alternative name(s):
    Pyruvate oxidoreductase gamma chain
      Short name=POR
    Pyruvic-ferredoxin oxidoreductase subunit gamma
Gene names
Name: porC
Synonyms: porG
Ordered Locus Names: TM_0015
OrganismThermotoga maritima [Complete proteome] [HAMAP]
Taxonomic identifier2336 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

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Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.

Subunit structure

Heterotetramer of one alpha, one beta, one delta and one gamma chain.

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Ontologies

Keywords
   Molecular functionOxidoreductase
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionpyruvate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 192191Pyruvate synthase subunit porC
PRO_0000099917

Experimental info

Sequence conflict231A → V in CAA59455. Ref.1

Secondary structure

1 ............................. 192
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
O05650-1 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: C58296B289254B70

FASTA19221,270
        10         20         30         40         50         60 
MPVAKKYFEI RWHGRAGQGA KSASQMLAEA ALEAGKYVQA FPEYGAERTG APMRAFNRIG 

        70         80         90        100        110        120 
DEYIRVRSAV ENPDVVVVID ETLLSPAIVE GLSEDGILLV NTVKDFEFVR KKTGFNGKIC 

       130        140        150        160        170        180 
VVDATDIALQ EIKRGIPNTP MLGALVRVTG IVPLEAIEKR IEKMFGKKFP QEVIDANKRA 

       190 
LRRGYEEVKC SE

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References

« Hide 'large scale' references
[1]"Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima."
Kletzin A., Adams M.W.W.
J. Bacteriol. 178:248-257(1996) [PubMed: 8550425] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-20.
Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
[2]"Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima."
Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. expand/collapse author list , Phillips C.A., Richardson D.L., Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.
Nature 399:323-329(1999) [PubMed: 10360571] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X85171 Genomic DNA. Translation: CAA59455.1. Different initiation.
AE000512 Genomic DNA. Translation: AAD35109.1. Different initiation.
PIRA72427. C59427.
RefSeqNP_227831.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2RAAX-ray2.12A1-192[»]
ModBaseSearch...

Genome annotation databases

GeneID896829.
GenomeReviewsGene locus TM_0015 in contig AE000512_GR.
KEGGtma:TM0015.
NMPDRfig|243274.1.peg.15.
TIGRTM_0015.

Phylogenomic databases

HOGENOMHBG553299.
OMAKEIRIHG.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-425.
TMAR243274:TM_0015-MONOMER.
BRENDA1.2.7.1. 16699.

Family and domain databases

InterProIPR011894. PorC_KorC.
IPR019752. Pyrv/ketoisovalerate_OxRed_cat.
IPR002869. Pyrv_flavodox_OxRed_cen.
[Graphical view]
Gene3DG3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
PfamPF01558. POR. 1 hit.
[Graphical view]
TIGRFAMsTIGR02175. PorC_KorC. 1 hit.
ProtoNetSearch...

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Entry information

Entry namePORC_THEMA
AccessionPrimary (citable) accession number: O05650
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: February 9, 2010
This is version 65 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents