O05650 (PORC_THEMA) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 78.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Pyruvate synthase subunit porC EC=1.2.7.1 Alternative name(s): Pyruvate oxidoreductase gamma chain Short name=POR Pyruvic-ferredoxin oxidoreductase subunit gamma | ||||||
| Gene names |
| ||||||
| Organism | Thermotoga maritima | ||||||
| Taxonomic identifier | 2336 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga |
Protein attributes
| Sequence length | 192 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+. |
| Subunit structure | Heterotetramer of one alpha, one beta, one delta and one gamma chain. |
| Sequence caution | The sequence AAD35109.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA59455.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Oxidoreductase |
| Technical term | 3D-structure Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Molecular function | pyruvate synthase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.1 | ||||||||||||||||||||||||||||||||||
| Chain | 2 – 192 | 191 | Pyruvate synthase subunit porC | PRO_0000099917 | |||||||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||||||||
| Sequence conflict | 23 | 1 | A → V in CAA59455. Ref.1 | ||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||
| Beta strand | 7 – 15 | 9 | |||||||||||||||||||||||||||||||||||
| Helix | 20 – 33 | 14 | |||||||||||||||||||||||||||||||||||
| Beta strand | 38 – 43 | 6 | |||||||||||||||||||||||||||||||||||
| Beta strand | 52 – 60 | 9 | |||||||||||||||||||||||||||||||||||
| Beta strand | 74 – 80 | 7 | |||||||||||||||||||||||||||||||||||
| Helix | 81 – 83 | 3 | |||||||||||||||||||||||||||||||||||
| Helix | 86 – 89 | 4 | |||||||||||||||||||||||||||||||||||
| Beta strand | 96 – 101 | 6 | |||||||||||||||||||||||||||||||||||
| Helix | 106 – 113 | 8 | |||||||||||||||||||||||||||||||||||
| Beta strand | 117 – 122 | 6 | |||||||||||||||||||||||||||||||||||
| Helix | 124 – 131 | 8 | |||||||||||||||||||||||||||||||||||
| Beta strand | 132 – 134 | 3 | |||||||||||||||||||||||||||||||||||
| Helix | 138 – 149 | 12 | |||||||||||||||||||||||||||||||||||
| Helix | 154 – 164 | 11 | |||||||||||||||||||||||||||||||||||
| Helix | 171 – 187 | 17 | |||||||||||||||||||||||||||||||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima." Kletzin A., Adams M.W.W. J. Bacteriol. 178:248-257(1996) [PubMed: 8550425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-20. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099. |
| [2] | "Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima." Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M., Cotton M.D., Pratt M.S. Fraser C.M.Nature 399:323-329(1999) [PubMed: 10360571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | X85171 Genomic DNA. Translation: CAA59455.1. Different initiation. AE000512 Genomic DNA. Translation: AAD35109.1. Different initiation. | ||||||||||||
| PIR | A72427. C59427. | ||||||||||||
| RefSeq | NP_227831.1. NC_000853.1. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | O05650. | ||||||||||||
| SMR | O05650. Positions 5-192. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| GeneID | 896829. | ||||||||||||
| GenomeReviews | Gene locus TM_0015 in contig AE000512_GR. | ||||||||||||
| KEGG | tma:TM0015. | ||||||||||||
| NMPDR | fig|243274.1.peg.15. | ||||||||||||
| PATRIC | 23934870. VBITheMar51294_0013. | ||||||||||||
| TIGR | TM_0015. | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | HBG553299. | ||||||||||||
| OMA | DYVIVQD. | ||||||||||||
| PhylomeDB | O05650. | ||||||||||||
| ProtClustDB | CLSK874924. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BioCyc | MetaCyc:MONOMER-425. TMAR243274:TM_0015-MONOMER. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR011894. PorC_KorC. IPR019752. Pyrv/ketoisovalerate_OxRed_cat. IPR002869. Pyrv_flavodox_OxRed_cen. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit. | ||||||||||||
| KO | K00172. | ||||||||||||
| Pfam | PF01558. POR. 1 hit. [Graphical view] | ||||||||||||
| SUPFAM | SSF53323. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit. | ||||||||||||
| TIGRFAMs | TIGR02175. PorC_KorC. 1 hit. | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Entry information
| Entry name | PORC_THEMA | ||||||||
| Accession | Primary (citable) accession number: O05650 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |

Clusters with