O05586 (Y1002_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein Rv1002c/MT1031
EC=2.4.-.-

Gene names

Ordered Locus Names:	Rv1002c, MT1031
ORF Names:	MTCI237.17c

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the glycosyltransferase 39 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	growth Inferred from mutant phenotype. Source: MTBBASE protein O-linked mannosylation Inferred from direct assay. Source: MTBBASE
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	mannosyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Uncharacterized protein Rv1002c/MT1031		PRO_0000121517
Regions
	Transmembrane	101 – 121	21	Helical; Potential
	Transmembrane	131 – 151	21	Helical; Potential
	Transmembrane	153 – 173	21	Helical; Potential
	Transmembrane	207 – 229	23	Helical; Potential
	Transmembrane	263 – 283	21	Helical; Potential
	Transmembrane	400 – 420	21	Helical; Potential
	Transmembrane	424 – 444	21	Helical; Potential
	Transmembrane	460 – 480	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O05586 [UniParc]. Last modified August 1, 1998. Version 2. Checksum: EB6226AA8F1442C6	FASTA	503	55,531
	10 20 30 40 50 60 MVPVVSPGPL VPVADFGPLD RLRGWIVTGL ITLLATVTRF LNLGSLTDAG TPIFDEKHYA 70 80 90 100 110 120 PQAWQVLNNH GVEDNPGYGL VVHPPVGKQL IAIGEAIFGY NGFGWRFTGA LLGVVLVALV 130 140 150 160 170 180 VRIVRRISRS TLVGAIAGVL LICDGVSFVT ARTALLDGFL TFFVVAAFGA LIVDRDQVRE 190 200 210 220 230 240 RMHIALLAGR SAATVWGPRV GVRWWRFGAG VLLGLACATK WSGVYFVLFF GAMALAFDVA 250 260 270 280 290 300 ARRQYQVQRP WLGTVRRDVL PSGYALGLIP FAVYLATYAP WFASETAIDR HAVGQAVGRN 310 320 330 340 350 360 SVVPLPDAVR SLWHYTAKAF HFHAGLTNSA GNYHPWESKP WTWPMSLRPV LYAIDQQDVA 370 380 390 400 410 420 GCGAQSCVKA EMLVGTPAMW WLAVPVLAYA GWRMFVRRDW RYAVVLVGYC AGWLPWFADI 430 440 450 460 470 480 DRQMYFFYAA TMAPFLVMGI SLVLGDILYH PGQGSERRTL GLIVVCCYVA LVVTNFAWLY 490 500 PVLTGLPISQ QTWNLEIWLP SWR

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842575 Genomic DNA. Translation: CAB08157.1. AE000516 Genomic DNA. Translation: AAK45281.1.
PIR	E70602.
RefSeq	NP_215518.1. NC_000962.2. NP_335467.1. NC_002755.2.
3D structure databases
ProteinModelPortal	O05586.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000002297; EBMYCP00000002297; EBMYCG00000002295. EBMYCT00000069952; EBMYCP00000068011; EBMYCG00000069947.
GeneID	887882. 925170.
GenomeReviews	Gene locus MT1031 in contig AE000516_GR. Gene locus Rv1002c in contig AL123456_GR.
KEGG	mtc:MT1031. mtu:Rv1002c.
PATRIC	18124012. VBIMycTub22151_1128.
TIGR	MT1031.
Organism-specific databases
TubercuList	Rv1002c.
Phylogenomic databases
GeneTree	EBGT00050000017439.
HOGENOM	HBG428988.
OMA	YAKDAWA.
ProtClustDB	CLSK790886.
Family and domain databases
InterPro	IPR003342. Glyco_trans_39. [Graphical view]
Pfam	PF02366. PMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y1002_MYCTU

Accession

Primary (citable) accession number: O05586

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program