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O05564 (METE_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
EC=2.1.1.14
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene names
Name:metE
Ordered Locus Names:ML0961
ORF Names:MLCB33.14
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length760 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7607605-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
PRO_0000098639

Sites

Metal binding6471Zinc By similarity
Metal binding6491Zinc By similarity
Metal binding7321Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
O05564 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 1E92FA570B9ACC97

FASTA76082,235
        10         20         30         40         50         60 
MDELVTTQSF TATVTGSPRI GPRRELKRAT EGYWAKRTSR SELESVASTL RRDMWSDLAA 

        70         80         90        100        110        120 
AGLDSVPVNT FSYYDQMLDT AFMLGALPAR VAQVSDDLDQ YFALARGNND IKPLEMTKWF 

       130        140        150        160        170        180 
DTNYHYLVPE IEPATTFSLN PGKILGELKE ALEQRIPSRP VIIGPVTFLL LSKGINGGGA 

       190        200        210        220        230        240 
PIQRLEELVG IYCTLLSLLA ENGARWVQFD EPALVTDLSP DAPALAEAVY TALGSVSKRP 

       250        260        270        280        290        300 
AIYVATYFGN PGASLAGLAR TPIEAIGVDF VCGADTSVAA VPELAGKTLV AGIVDGRNIW 

       310        320        330        340        350        360 
RTDLESALSK LATLLGSAAT VAVSTSCSTL HVPYSLEPET DLDDNLRSWL AFGAEKVAEV 

       370        380        390        400        410        420 
VVLARALRDG RDAVADEIAA SNAAVASRRS DPRLHNGQVR ARIDSIVASG THRGDAAQRR 

       430        440        450        460        470        480 
TSQDARLHLP PLPTTTIGSY PQTSAIRKAR AALQDAEIDE AEYISRMKKE VADAIKLQEQ 

       490        500        510        520        530        540 
LGLDVLVHGE PERNDMVQYF AEQLGGFFAT QNGWVQSYGS RCVRPPILYG DVSRPHPMTI 

       550        560        570        580        590        600 
EWITYAQSLT DKPVKGMLTG PVTILAWSFV RDDQPLADTA NQVALAIRDE TVDLQSAGIA 

       610        620        630        640        650        660 
IIQVDEPALR ELLPLRRADQ DEYLCWAVKA FRLATSGVAD STQIHTHLCY SEFGEVIGAI 

       670        680        690        700        710        720 
ADLDADVTSI EAARSHMEVL DDLNAVGFAN SIGPGVYDIH SPRVPSTDEI AKSLRAALKA 

       730        740        750        760 
IPMQRLWVNP DCGLKTRSVD EVSASLQNMV AAARQVRAGA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z94723 Genomic DNA. Translation: CAB08123.1.
AL583920 Genomic DNA. Translation: CAC31342.1.
PIRC87029.
RefSeqNP_301723.1. NC_002677.1.

3D structure databases

ProteinModelPortalO05564.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000028777; EBMYCP00000028383; EBMYCG00000028772.
GeneID909974.
GenomeReviewsGene locus ML0961 in contig AL450380_GR.
KEGGmle:ML0961.
NMPDRfig|272631.1.peg.595.
PATRIC18053594. VBIMycLep78757_1742.

Organism-specific databases

LepromaML0961.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017657.
HOGENOMHBG287495.
OMARNIWRAN.
ProtClustDBPRK05222.

Enzyme and pathway databases

BioCycMLEP272631:ML0961-MONOMER.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETE_MYCLE
AccessionPrimary (citable) accession number: O05564
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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