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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarityNote: Binds 4 Mg2+ ions per subunit. Other metal ions can support activity, but at a lower rate. Two Mg2+ ions are required for the activation of the enzyme and are present before substrate binds, two additional Mg2+ ions form complexes with substrate and product.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Magnesium 1By similarity
Metal bindingi70 – 701Magnesium 1By similarity
Metal bindingi70 – 701Magnesium 2By similarity
Metal bindingi102 – 1021Magnesium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciGOXY290633:GHB3-755-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:ppa
Ordered Locus Names:GOX0757
OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Taxonomic identifieri290633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
Proteomesi
  • UP000006375 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Inorganic pyrophosphatasePRO_0000137498Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290633.GOX0757.

Structurei

3D structure databases

ProteinModelPortaliO05545.
SMRiO05545. Positions 14-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236472.
KOiK01507.
OMAiAVYYPAN.
OrthoDBiPOG091H05Q5.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.

Sequencei

Sequence statusi: Complete.

O05545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVSKISPGK DLPNDINVVI EIPQGSQVKY EVDKDSGALV VDRFLFTPMA
60 70 80 90 100
YPAAYGFIPG TLAADGDPAD ALVLTPAAVV PGSVIRARPI GMLKMEDESG
110 120 130 140 150
QDEKIICVPH DKVHPQFSNV HSVDDLPEIT KKAITHFFER YKDLEPNKWV
160 170
KVTGWADKAE AGKVIMEALA AAK
Length:173
Mass (Da):18,798
Last modified:March 15, 2005 - v3
Checksum:i40EF528DA03F7226
GO

Sequence cautioni

The sequence BAA19757 differs from that shown. Reason: Frameshift at positions 50, 65 and 111. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86440 Genomic DNA. Translation: BAA19757.1. Frameshift.
CP000009 Genomic DNA. Translation: AAW60533.1.
RefSeqiWP_011252330.1. NC_006677.1.

Genome annotation databases

EnsemblBacteriaiAAW60533; AAW60533; GOX0757.
KEGGigox:GOX0757.
PATRICi32609250. VBIGluOxy81109_1001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86440 Genomic DNA. Translation: BAA19757.1. Frameshift.
CP000009 Genomic DNA. Translation: AAW60533.1.
RefSeqiWP_011252330.1. NC_006677.1.

3D structure databases

ProteinModelPortaliO05545.
SMRiO05545. Positions 14-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290633.GOX0757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW60533; AAW60533; GOX0757.
KEGGigox:GOX0757.
PATRICi32609250. VBIGluOxy81109_1001.

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236472.
KOiK01507.
OMAiAVYYPAN.
OrthoDBiPOG091H05Q5.

Enzyme and pathway databases

BioCyciGOXY290633:GHB3-755-MONOMER.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIPYR_GLUOX
AccessioniPrimary (citable) accession number: O05545
Secondary accession number(s): Q5FSW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 15, 2005
Last modified: September 7, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.