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Protein

Sec-independent protein translocase protein TatAy

Gene

tatAy

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. Required for YwbN secretion.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU05980-MONOMER.

Protein family/group databases

TCDBi2.A.64.3.2. the twin arginine targeting (tat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sec-independent protein translocase protein TatAyUniRule annotation
Gene namesi
Name:tatAyUniRule annotation
Synonyms:ydiI
Ordered Locus Names:BSU05980
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5757Sec-independent protein translocase protein TatAyPRO_0000097980Add
BLAST

Proteomic databases

PaxDbiO05522.

Interactioni

Subunit structurei

Forms a complex with TatCy. Two types of complexes exist: one composed of TatAy and TatCy, and another composed only of TatAy. Cytosolic TatA forms large complexes or aggregates.UniRule annotation1 Publication

Protein-protein interaction databases

IntActiO05522. 16 interactions.
STRINGi224308.Bsubs1_010100003348.

Family & Domainsi

Sequence similaritiesi

Belongs to the TatA/E family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41067S4. Bacteria.
ENOG410XUF0. LUCA.
HOGENOMiHOG000245365.
InParanoidiO05522.
KOiK03116.
OMAiKAGARDM.
OrthoDBiEOG6WQD34.
PhylomeDBiO05522.

Family and domain databases

HAMAPiMF_00236. TatA_E.
InterProiIPR003369. TatA/B/E.
IPR006312. TatA/E.
[Graphical view]
PfamiPF02416. MttA_Hcf106. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01411. tatAE. 1 hit.

Sequencei

Sequence statusi: Complete.

O05522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIGPGSLAV IAIVALIIFG PKKLPELGKA AGDTLREFKN ATKGLTSDEE

EKKKEDQ
Length:57
Mass (Da):6,065
Last modified:July 1, 1997 - v1
Checksum:i91E4CB4138D8E751
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88802 Genomic DNA. Translation: BAA19722.1.
AL009126 Genomic DNA. Translation: CAB12417.1.
PIRiB69787.
RefSeqiNP_388479.1. NC_000964.3.
WP_003234072.1. NZ_JNCM01000032.1.

Genome annotation databases

EnsemblBacteriaiCAB12417; CAB12417; BSU05980.
GeneIDi939878.
KEGGibsu:BSU05980.
PATRICi18972828. VBIBacSub10457_0628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88802 Genomic DNA. Translation: BAA19722.1.
AL009126 Genomic DNA. Translation: CAB12417.1.
PIRiB69787.
RefSeqiNP_388479.1. NC_000964.3.
WP_003234072.1. NZ_JNCM01000032.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO05522. 16 interactions.
STRINGi224308.Bsubs1_010100003348.

Protein family/group databases

TCDBi2.A.64.3.2. the twin arginine targeting (tat) family.

Proteomic databases

PaxDbiO05522.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12417; CAB12417; BSU05980.
GeneIDi939878.
KEGGibsu:BSU05980.
PATRICi18972828. VBIBacSub10457_0628.

Phylogenomic databases

eggNOGiENOG41067S4. Bacteria.
ENOG410XUF0. LUCA.
HOGENOMiHOG000245365.
InParanoidiO05522.
KOiK03116.
OMAiKAGARDM.
OrthoDBiEOG6WQD34.
PhylomeDBiO05522.

Enzyme and pathway databases

BioCyciBSUB:BSU05980-MONOMER.

Family and domain databases

HAMAPiMF_00236. TatA_E.
InterProiIPR003369. TatA/B/E.
IPR006312. TatA/E.
[Graphical view]
PfamiPF02416. MttA_Hcf106. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01411. tatAE. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and analysis of the phoB-rrnE-groESL region of the Bacillus subtilis chromosome."
    Sadaie Y., Yata K., Fujita M., Sagai H., Itaya M., Kasahara Y., Ogasawara N.
    Microbiology 143:1861-1866(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway."
    Jongbloed J.D.H., Martin U., Antelmann H., Hecker M., Tjalsma H., Venema G., Bron S., van Dijl J.M., Mueller J.
    J. Biol. Chem. 275:41350-41357(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF THE TAT GENES.
  4. Cited for: EXPORT OF THE YWBN PROTEIN, CHARACTERIZATION OF THE TWO TAT TRANSLOCASE SYSTEMS.
  5. "The twin-arginine translocation (Tat) systems from Bacillus subtilis display a conserved mode of complex organization and similar substrate recognition requirements."
    Barnett J.P., van der Ploeg R., Eijlander R.T., Nenninger A., Mendel S., Rozeboom R., Kuipers O.P., van Dijl J.M., Robinson C.
    FEBS J. 276:232-243(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTATAY_BACSU
AccessioniPrimary (citable) accession number: O05522
Secondary accession number(s): Q797D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 1, 1997
Last modified: February 17, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

B.subtilis possesses two minimal, substrate-specific, Tat translocases: TatAd-TatCd and TatAy-TatCy, each one composed of a TatA and a TatC protein. TatA is bifunctional and performs the function of both the TatA and TatB proteins of Gram-negative organisms.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.