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Reviewed, UniProtKB/Swiss-Prot O05514 (THIL_BACSU)

Last modified November 3, 2009. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Thiamine-monophosphate kinase
      Short name=Thiamine-phosphate kinase
    EC=2.7.4.16
Gene names
Name: thiL
Synonyms: ydiA, ydxA
Ordered Locus Names: BSU05900
OrganismBacillus subtilis [Complete proteome] [HAMAP]
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

ATP + thiamine phosphate = ADP + thiamine diphosphate.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.

Sequence similarities

Belongs to the thiamine-monophosphate kinase family.

Sequence caution

The sequence AAA72334.1 differs from that shown. Reason: Frameshift at position 121.

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Ontologies

Keywords
   Biological processThiamine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processthiamin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thiamin phosphate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Thiamine-monophosphate kinase
PRO_0000096191

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Sequences

Sequence LengthMass (Da)Tools
O05514-1 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 95D2D6762CFDBCCB

FASTA32535,884
        10         20         30         40         50         60 
MDEFDLIHSI TPRTIHHSSV DVGIGDDAAL YTAKHGVQEI VCVDTMVEDV HFKLHYSSPE 

        70         80         90        100        110        120 
DIGYKALAVN ISDIAAMGGI PKFYLVSLAV PSKWTESEIK AMYEGMNELA KLYHMDLIGG 

       130        140        150        160        170        180 
DTVSTADKLV VTVTVIGEIE KGQACLRSLA KPNDIVFVTG EIGSSAAGLS LLLEETNPQN 

       190        200        210        220        230        240 
SSVETDYFIH RHKRPEPRVS VGRLCSIFKR AALNDVSDGL ASELNEIAEA SCVSIEIVES 

       250        260        270        280        290        300 
MLPIHSDLPK LHPNWKEWAL FGGEDFELTG TVSNEEWEVL KQECAALHLP ITKIGYVREK 

       310        320 
TKSKVILKTD QTSMILEKKG YNHFK

« Hide

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References

« Hide 'large scale' references
[1]"Nucleotide sequence and analysis of the phoB-rrnE-groESL region of the Bacillus subtilis chromosome."
Sadaie Y., Yata K., Fujita M., Sagai H., Itaya M., Kasahara Y., Ogasawara N.
Microbiology 143:1861-1866(1997) [PubMed: 9202461] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / JH642.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"Two tRNA gene clusters associated with rRNA operons rrnD and rrnE in Bacillus subtilis."
Rudner R., Chevrestt A., Bucholz S.R., Studamire B., White A.M., Jarvis E.D.
J. Bacteriol. 175:503-509(1993) [PubMed: 8419296] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-166.

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Cross-references

Sequence databases

D88802 Genomic DNA. Translation: BAA19714.1. Different initiation.
AL009126 Genomic DNA. Translation: CAB12409.1.
L08236 Genomic DNA. Translation: AAA72334.1. Frameshift.
PIRB69786.
RefSeqNP_388471.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID939867.
GenomeReviewsGene locus BSU05900 in contig AL009126_GR.
KEGGbsu:BSU05900.
NMPDRfig|224308.1.peg.590.

Organism-specific databases

SubtiListBG10693. thiL. [Micado]
CMRSearch...

Phylogenomic databases

HOGENOMO05514.
OMAMGAEPAW.

Enzyme and pathway databases

BioCycBSUB224308:BSU0590-MON.
BRENDA2.7.4.16. 150.

Family and domain databases

InterProIPR000728. AIR_synth.
IPR010918. AIR_synth_C.
IPR006283. ThiL.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
PIRSFPIRSF005303. Thiam_monoph_kin. 1 hit.
TIGRFAMsTIGR01379. thiL. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameTHIL_BACSU
AccessionPrimary (citable) accession number: O05514
Secondary accession number(s): Q05875
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 3, 2009
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents