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Protein

Probable mannose-6-phosphate isomerase GmuF

Gene

gmuF

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be involved in the degradation of glucomannan.1 Publication

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi95ZincBy similarity1
Metal bindingi97ZincBy similarity1
Metal bindingi115ZincBy similarity1
Metal bindingi172ZincBy similarity1
Active sitei192By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciBSUB:BSU05870-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannose-6-phosphate isomerase GmuF (EC:5.3.1.8)
Alternative name(s):
Glucomannan utilization protein F
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:gmuF
Synonyms:ydhS
Ordered Locus Names:BSU05870
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003724351 – 315Probable mannose-6-phosphate isomerase GmuFAdd BLAST315

Proteomic databases

PaxDbiO05511
PRIDEiO05511

Expressioni

Inductioni

Up-regulated by konjac glucomannan and by cellobiose and mannobiose, the possible degradation products of glucomannan. Repressed by glucose via the carbon catabolite repression system. Also repressed by GmuR.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100003288

Structurei

3D structure databases

ProteinModelPortaliO05511
SMRiO05511
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DG6 Bacteria
COG1482 LUCA
HOGENOMiHOG000054245
InParanoidiO05511
KOiK01809
OMAiENEPWGK
PhylomeDBiO05511

Family and domain databases

Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR001250 Man6P_Isoase-1
IPR014628 Man6P_isomerase_Firm_short
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PfamiView protein in Pfam
PF01238 PMI_typeI, 1 hit
PIRSFiPIRSF036894 PMI_Firm_short, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR00218 manA, 2 hits

Sequencei

Sequence statusi: Complete.

O05511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHPLFLEPV FKERLWGGTK LRDAFGYAIP SQKTGECWAV SAHAHGSSSV
60 70 80 90 100
KNGPLAGKTL DQVWKDHPEI FGFPDGKVFP LLVKLLDANM DLSVQVHPDD
110 120 130 140 150
DYAKLHENGD LGKTECWYII DCKDDAELIL GHHASTKEEF KQRIESGDWN
160 170 180 190 200
GLLRRIKIKP GDFFYVPSGT LHALCKGTLV LEIQQNSDTT YRVYDYDRCN
210 220 230 240 250
DQGQKRTLHI EKAMEVITIP HIDKVHTPEV KEVGNAEIIV YVQSDYFSVY
260 270 280 290 300
KWKISGRAAF PSYQTYLLGS VLSGSGRIIN NGIQYECNAG SHFILPAHFG
310
EFTIEGTCEF MISHP
Length:315
Mass (Da):35,492
Last modified:July 1, 1997 - v1
Checksum:iED6F1855D41B4DDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88802 Genomic DNA Translation: BAA19711.1
AL009126 Genomic DNA Translation: CAB12406.1
PIRiG69785
RefSeqiNP_388468.1, NC_000964.3
WP_003242491.1, NZ_JNCM01000031.1

Genome annotation databases

EnsemblBacteriaiCAB12406; CAB12406; BSU05870
GeneIDi938028
KEGGibsu:BSU05870
PATRICifig|224308.179.peg.631

Similar proteinsi

Entry informationi

Entry nameiMANA2_BACSU
AccessioniPrimary (citable) accession number: O05511
Secondary accession number(s): Q797D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health