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O05511

- MANA2_BACSU

UniProt

O05511 - MANA2_BACSU

Protein

Probable mannose-6-phosphate isomerase GmuF

Gene

gmuF

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Seems to be involved in the degradation of glucomannan.1 Publication

    Catalytic activityi

    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi95 – 951ZincBy similarity
    Metal bindingi97 – 971ZincBy similarity
    Metal bindingi115 – 1151ZincBy similarity
    Metal bindingi172 – 1721ZincBy similarity
    Active sitei192 – 1921By similarity

    GO - Molecular functioni

    1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBSUB:BSU05870-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable mannose-6-phosphate isomerase GmuF (EC:5.3.1.8)
    Alternative name(s):
    Glucomannan utilization protein F
    Phosphohexomutase
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    Name:gmuF
    Synonyms:ydhS
    Ordered Locus Names:BSU05870
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU05870. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Probable mannose-6-phosphate isomerase GmuFPRO_0000372435Add
    BLAST

    Proteomic databases

    PaxDbiO05511.

    Expressioni

    Inductioni

    Up-regulated by konjac glucomannan and by cellobiose and mannobiose, the possible degradation products of glucomannan. Repressed by glucose via the carbon catabolite repression system. Also repressed by GmuR.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU05870.

    Structurei

    3D structure databases

    ProteinModelPortaliO05511.
    SMRiO05511. Positions 2-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1482.
    HOGENOMiHOG000054245.
    KOiK01809.
    OMAiPLATHIF.
    OrthoDBiEOG66MQQS.
    PhylomeDBiO05511.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR001250. Man6P_Isoase-1.
    IPR014628. Man6P_isomerase_Firm_short.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF01238. PMI_typeI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036894. PMI_Firm_short. 1 hit.
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR00218. manA. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    O05511-1 [UniParc]FASTAAdd to Basket

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    MTHPLFLEPV FKERLWGGTK LRDAFGYAIP SQKTGECWAV SAHAHGSSSV    50
    KNGPLAGKTL DQVWKDHPEI FGFPDGKVFP LLVKLLDANM DLSVQVHPDD 100
    DYAKLHENGD LGKTECWYII DCKDDAELIL GHHASTKEEF KQRIESGDWN 150
    GLLRRIKIKP GDFFYVPSGT LHALCKGTLV LEIQQNSDTT YRVYDYDRCN 200
    DQGQKRTLHI EKAMEVITIP HIDKVHTPEV KEVGNAEIIV YVQSDYFSVY 250
    KWKISGRAAF PSYQTYLLGS VLSGSGRIIN NGIQYECNAG SHFILPAHFG 300
    EFTIEGTCEF MISHP 315
    Length:315
    Mass (Da):35,492
    Last modified:July 1, 1997 - v1
    Checksum:iED6F1855D41B4DDF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88802 Genomic DNA. Translation: BAA19711.1.
    AL009126 Genomic DNA. Translation: CAB12406.1.
    PIRiG69785.
    RefSeqiNP_388468.1. NC_000964.3.
    WP_003242491.1. NZ_CM000487.1.

    Genome annotation databases

    EnsemblBacteriaiCAB12406; CAB12406; BSU05870.
    GeneIDi938028.
    KEGGibsu:BSU05870.
    PATRICi18972790. VBIBacSub10457_0616.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88802 Genomic DNA. Translation: BAA19711.1 .
    AL009126 Genomic DNA. Translation: CAB12406.1 .
    PIRi G69785.
    RefSeqi NP_388468.1. NC_000964.3.
    WP_003242491.1. NZ_CM000487.1.

    3D structure databases

    ProteinModelPortali O05511.
    SMRi O05511. Positions 2-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU05870.

    Proteomic databases

    PaxDbi O05511.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB12406 ; CAB12406 ; BSU05870 .
    GeneIDi 938028.
    KEGGi bsu:BSU05870.
    PATRICi 18972790. VBIBacSub10457_0616.

    Organism-specific databases

    GenoListi BSU05870. [Micado ]

    Phylogenomic databases

    eggNOGi COG1482.
    HOGENOMi HOG000054245.
    KOi K01809.
    OMAi PLATHIF.
    OrthoDBi EOG66MQQS.
    PhylomeDBi O05511.

    Enzyme and pathway databases

    BioCyci BSUB:BSU05870-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR001250. Man6P_Isoase-1.
    IPR014628. Man6P_isomerase_Firm_short.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF01238. PMI_typeI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036894. PMI_Firm_short. 1 hit.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR00218. manA. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and analysis of the phoB-rrnE-groESL region of the Bacillus subtilis chromosome."
      Sadaie Y., Yata K., Fujita M., Sagai H., Itaya M., Kasahara Y., Ogasawara N.
      Microbiology 143:1861-1866(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168 / JH642.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "Glucomannan utilization operon of Bacillus subtilis."
      Sadaie Y., Nakadate H., Fukui R., Yee L.M., Asai K.
      FEMS Microbiol. Lett. 279:103-109(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, FUNCTION IN GLUCOMANNAN UTILIZATION.
      Strain: 168.

    Entry informationi

    Entry nameiMANA2_BACSU
    AccessioniPrimary (citable) accession number: O05511
    Secondary accession number(s): Q797D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3