Reviewed, UniProtKB/Swiss-Prot O05412 (MURI2_BACSU)

Names and origin

Protein names

Recommended name:
    Glutamate racemase 2
    EC=5.1.1.3

Gene names

Name:	yrpC
Ordered Locus Names:	BSU26810

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Provides the (R)-glutamate required for cell wall biosynthesis By similarity. HAMAP MF_00258
Catalytic activity	L-glutamate = D-glutamate. HAMAP MF_00258
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00258
Sequence similarities	Belongs to the aspartate/glutamate racemases family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate racemase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Glutamate racemase 2 HAMAP MF_00258		PRO_0000095454

Sequences

	Sequence		Length	Mass (Da)
	O05412-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 06F1FE75EBF0AD68	FASTA	265	29,876
	10 20 30 40 50 60 MKIGFFDSGI GGMTVLYEAI KVLPYEDYIF YADTLNVPYG EKSKGKVKEY IFNAAEFLAS 70 80 90 100 110 120 QNIKALVIAC NTATSIAIED LRRNFDFPII GIEPAVKPAI NKCTEERKRV LVVATNLTLK 130 140 150 160 170 180 EEKFHNLVKE IDHHDLVDCL ALPGLVEFAE NFDFSEDKII KYLKNELSSF DLKQYGTIVL 190 200 210 220 230 240 GCTHFPFFKN SFEKLFGIKV DMISGSVGTA KQLKKVLADR NQLGKGSGSI TFFNSGHKIV 250 260 DQEVISKYKR LFEILDETQR SHVGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of the Bacillus subtilis genome region in the vicinity of the lev operon reveals two new extracytoplasmic function RNA polymerase sigma factors SigV and SigZ." Sorokin A., Bolotin A., Purnelle B., Hilbert H., Lauber J., Duesterhoeft A., Ehrlich S.D. Microbiology 143:2939-2943(1997) [PubMed: 9308178] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[3]	"Characterization of yrpC gene product of Bacillus subtilis IFO 3336 as glutamate racemase isozyme." Ashiuchi M., Soda K., Misono H. Biosci. Biotechnol. Biochem. 63:792-798(1999) [PubMed: 10380621] [Abstract] Cited for: CHARACTERIZATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U93875 Genomic DNA. Translation: AAB80890.1. AL009126 Genomic DNA. Translation: CAB14622.1.
PIR	C69978.
RefSeq	NP_390558.1.
3D structure databases
SMR	O05412. Positions 2-239.
ModBase	Search...
Genome annotation databases
GeneID	937619.
GenomeReviews	Gene locus BSU26810 in contig AL009126_GR.
KEGG	bsu:BSU26810.
NMPDR	fig|224308.1.peg.2683.
Organism-specific databases
SubtiList	BG12306. yrpC. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	HBG645102.
OMA	GCTHYLH.
PhylomeDB	O05412.
Enzyme and pathway databases
BRENDA	5.1.1.3. 150.
Family and domain databases
HAMAP	MF_00258. Glu_racemase. [Tree]
InterPro	IPR015942. Asp/Glu/hydantoin_racemase. IPR001920. Asp/Glu_race. IPR018187. Asp/Glu_racemase_AS. IPR004391. Glu_race. [Graphical view]
Gene3D	G3DSA:3.40.50.1860. Asp/Glu_race. 1 hit.
Pfam	PF01177. Asp_Glu_race. 1 hit. [Graphical view]
TIGRFAMs	TIGR00067. glut_race. 1 hit.
PROSITE	PS00923. ASP_GLU_RACEMASE_1. 1 hit. PS00924. ASP_GLU_RACEMASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURI2_BACSU

Accession

Primary (citable) accession number: O05412

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	July 1, 1997
Last modified:	February 9, 2010
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)