O05386 (KCY_BACC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	BCE_1623

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Cytidylate kinase HAMAP MF_00238		PRO_0000131873
Regions
	Nucleotide binding	11 – 19	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	O05386 [UniParc]. Last modified May 24, 2004. Version 2. Checksum: 8172B5383404125B	FASTA	225	25,289
	10 20 30 40 50 60 MDKRISIAID GPAAAGKSTV AKVVAKKLSY VYIDTGAMYR TITYAALEQK VDIENEEQLM 70 80 90 100 110 120 EVVKNVKIEF QQGENTQLVF LNGQDVSEVI RTPEVTNRVS IVAKHRLVRE EMVRRQQELA 130 140 150 160 170 180 EKGGVVMDGR DIGTHVLPDA EVKIFMLASV EERAERRHLE NMNKGFDSNL EQLKEEIAQR 190 200 210 220 DKLDSEREVS PLKKADDALE LDTTSLSIEE VVQKIMSIVS GVFAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10987.
[2]	"Genome organization is not conserved between Bacillus cereus and Bacillus subtilis." Oekstad O.A., Hegna I.K., Lindbaeck T., Rishovd A.-L., Kolstoe A.-B. Microbiology 145:621-631(1999) [PubMed: 10217496] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-225.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017194 Genomic DNA. Translation: AAS40552.1. Y08953 Genomic DNA. Translation: CAA70151.1.
RefSeq	NP_977944.1. NC_003909.8.
3D structure databases
ProteinModelPortal	O05386.
SMR	O05386. Positions 3-220.
ModBase	Search...
Protein-protein interaction databases
STRING	O05386.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000026053; EBBACP00000025403; EBBACG00000026044.
GeneID	2752151.
GenomeReviews	Gene locus BCE_1623 in contig AE017194_GR.
KEGG	bca:BCE_1623.
NMPDR	fig|222523.1.peg.1616.
PATRIC	18852077. VBIBacCer118379_1542.
TIGR	BCE_1623.
Phylogenomic databases
eggNOG	COG0283.
GeneTree	EBGT00050000002974.
HOGENOM	HBG354377.
OMA	DIGTVIC.
ProtClustDB	PRK00023.
Enzyme and pathway databases
BioCyc	BCER405917:BCE_1623-MONOMER.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
KO	K00945.
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. Cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_BACC1

Accession

Primary (citable) accession number: O05386

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 24, 2004
Last modified:	January 25, 2012
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program