Reviewed,
UniProtKB/Swiss-Prot O05269 (GUAC_BACSU)
Last modified
June 16, 2009.
Version 57.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: GMP reductase EC=1.7.1.7 Alternative name(s): Guanosine 5'-monophosphate oxidoreductase Short name=Guanosine monophosphate reductase | ||||||
| Gene names |
| ||||||
| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1423 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 326 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides Probable. |
| Catalytic activity | Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511 |
| Induction | Expression is regulated by purR. HAMAP MF_01511 |
| Sequence similarities | Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW purine nucleotide metabolic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | GMP reductase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 326 | 326 | GMP reductase HAMAP MF_01511 | PRO_0000093752 | |||||
Regions | |||||||||
| Nucleotide binding | 204 – 227 | 24 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 175 | 1 | Thioimidate intermediate By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Oudega B., Koningstein G., de Sales Ramon M., Rodrigues L. Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.  Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [3] | "Definition of the Bacillus subtilis PurR operator using genetic and bioinformatic tools and expansion of the PurR regulon with glyA, guaC, pbuG, xpt-pbuX, yqhZ-folD, and pbuO." Saxild H.H., Brunstedt K., Nielsen K.I., Jarmer H., Nygaard P. J. Bacteriol. 183:6175-6183(2001) [PubMed: 11591660] [Abstract] Cited for: PROBABLE FUNCTION, REGULATION OF EXPRESSION. Strain: 168. |
Cross-references
Sequence databases | |
|---|---|
| Z93939 Genomic DNA. Translation: CAB07955.1. Z99120 Genomic DNA. Translation: CAB15203.1. | |
| PIR | C70015. |
| RefSeq | NP_391093.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1B3O based on UniProtKB P12268. |
| SMR | O05269. Positions 1-321. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 937189. |
| GenomeReviews | Gene locus BSU32130 in contig AL009126_GR. |
| KEGG | bsu:BSU32130. |
| NMPDR | fig|224308.1.peg.3219. |
Organism-specific databases | |
| SubtiList | BG12392. guaC. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | O05269. |
| OMA | O05269. NSRSECD. |
Enzyme and pathway databases | |
| BioCyc | BSUB224308:BSU3210-MON. |
| BRENDA | 1.7.1.7. 150. |
Family and domain databases | |
| HAMAP | MF_01511. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR005994. GMP_reduct2. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF00478. IMPDH. 1 hit. [Graphical view] |
| PIRSF | PIRSF036500. GMP_red_Firmic. 1 hit. |
| TIGRFAMs | TIGR01306. GMP_reduct_2. 1 hit. |
| PROSITE | PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GUAC_BACSU | ||||||||
| Accession | Primary (citable) accession number: O05269 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| SIMILARITY comments Index of protein domains and families |
