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Protein

Sensor histidine kinase MalK

Gene

malK

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Member of a two-component regulatory system MalK/MalR. Involved in the activation of maeA, maeN and yflS in presence of malate. Probably activates MalR by phosphorylation.2 Publications

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU31520-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor histidine kinase MalK (EC:2.7.13.3)
Alternative name(s):
Malate kinase sensor
Gene namesi
Name:malK
Synonyms:yufL
Ordered Locus Names:BSU31520
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 32HelicalSequence analysisAdd BLAST23
Topological domaini33 – 172ExtracellularSequence analysisAdd BLAST140
Transmembranei173 – 195HelicalSequence analysisAdd BLAST23
Topological domaini196 – 533CytoplasmicSequence analysisAdd BLAST338

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000748041 – 533Sensor histidine kinase MalKAdd BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei338Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO05250
PRIDEiO05250

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100017131

Structurei

3D structure databases

ProteinModelPortaliO05250
SMRiO05250
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 281PASAdd BLAST72
Domaini335 – 527Histidine kinasePROSITE-ProRule annotationAdd BLAST193

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3290 LUCA
HOGENOMiHOG000241936
InParanoidiO05250
KOiK11614
OMAiHYQNGWL
PhylomeDBiO05250

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR000014 PAS
IPR013767 PAS_fold
IPR033463 sCache_3
IPR029151 Sensor-like_sf
IPR004358 Sig_transdc_His_kin-like_C
IPR016120 Sig_transdc_His_kin_SpoOB
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00989 PAS, 1 hit
PF17203 sCache_3_2, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF103190 SSF103190, 1 hit
SSF55874 SSF55874, 1 hit
SSF55890 SSF55890, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit

Sequencei

Sequence statusi: Complete.

O05250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTLKLQTR LTIFVCIVVL IALLITFFTV GAQTTKRIRD QEKATALQTA
60 70 80 90 100
EMVAEAPMTA AALESGKKQK ELQSYTKRVQ KITGTEFVVV MDMNGIRKTH
110 120 130 140 150
PDPSKIGKKF RGGDESEVLK GHVHISTASG TLGKSQRAFV PVYAENGKQV
160 170 180 190 200
GAVAVGITVN EIDEVISHSL RPLYFIICVS IFVGVIGAVI VARTVKNIMY
210 220 230 240 250
GLEPYEIATL LEERSAMLES TKEGILAVDE HGKIKLANAE AKRLFVKMGI
260 270 280 290 300
NTNPIDQDVD DILPKSRLKK VIETKKPLQD RDVRINGLEL VFNEVPIQLK
310 320 330 340 350
GQTVGAIATF RDKTEVKHLA EQLSGVKMYA NALRAQSHEF MNKLHVILGL
360 370 380 390 400
VQLKEYDDLG DYIKDIAIQQ KSETSEIIND VKSSVLAGFL LGKQSFIREQ
410 420 430 440 450
GANLDIECNG VIPNAADPSV IHELITIIGN LINNGLDAVA DMPKKQITMS
460 470 480 490 500
MRFHNSILDI EITDTGAGMS EEDQAKVFEQ GYSTKGKNRG FGLYFTQQSI
510 520 530
ENLKGQMILT SEKNEGTTFS IRIPYEPKEE NHD
Length:533
Mass (Da):58,930
Last modified:July 1, 1997 - v1
Checksum:i9CDF9A58EFD5AA10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93937 Genomic DNA Translation: CAB07946.1
AL009126 Genomic DNA Translation: CAB15141.1
PIRiA70009
RefSeqiNP_391030.1, NC_000964.3
WP_003228835.1, NZ_JNCM01000033.1

Genome annotation databases

EnsemblBacteriaiCAB15141; CAB15141; BSU31520
GeneIDi937173
KEGGibsu:BSU31520
PATRICifig|224308.179.peg.3417

Similar proteinsi

Entry informationi

Entry nameiMALK_BACSU
AccessioniPrimary (citable) accession number: O05250
Secondary accession number(s): Q795M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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