Reviewed,
UniProtKB/Swiss-Prot O05218 (YWRD_BACSU)
Last modified
February 9, 2010.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Putative gamma-glutamyltransferase ywrD EC=2.3.2.2 Cleaved into the following 2 chains: 1- Recommended name: Gamma-glutamyltranspeptidase large chain 2- Recommended name: Gamma-glutamyltranspeptidase small chain | ||||
| Gene names |
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| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1423 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 525 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid. |
| Subunit structure | This enzyme consists of two polypeptide chains, which are synthesized from a single polypeptide By similarity. |
| Induction | Positively regulated by tnrA under nitrogen-limited conditions. Ref.3 |
| Miscellaneous | Is not involved in the utilization of extracellular glutathione as a sulfur source. |
| Sequence similarities | Belongs to the gamma-glutamyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Acyltransferase Transferase |
| PTM | Zymogen |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | acyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW gamma-glutamyltransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees)." Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V., Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H., Villani G., Kunst F., Danchin A., Glaser P. Microbiology 143:3313-3328(1997) [PubMed: 9353933] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [3] | "Identification of additional TnrA-regulated genes of Bacillus subtilis associated with a TnrA box." Yoshida K., Yamaguchi H., Kinehara M., Ohki Y.-H., Nakaura Y., Fujita Y. Mol. Microbiol. 49:157-165(2003) [PubMed: 12823818] [Abstract] Cited for: INDUCTION BY TNRA. |
| [4] | "Gamma-glutamyltranspeptidase, but not YwrD, is important in utilization of extracellular glutathione as a sulfur source in Bacillus subtilis." Minami H., Suzuki H., Kumagai H. J. Bacteriol. 186:1213-1214(2004) [PubMed: 14762019] [Abstract] Cited for: LACK OF FUNCTION IN GLUTATHIONE METABOLISM. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z93767 Genomic DNA. Translation: CAB07790.1. AL009126 Genomic DNA. Translation: CAB15627.1. |
| PIR | F70068. |
| RefSeq | NP_391491.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2DG5 based on UniProtKB P18956. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | T03.014. |
Genome annotation databases | |
| GeneID | 936884. |
| GenomeReviews | Gene locus BSU36100 in contig AL009126_GR. |
| KEGG | bsu:BSU36100. |
| NMPDR | fig|224308.1.peg.3617. |
Organism-specific databases | |
| SubtiList | BG12523. ywrD. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG738311. |
| OMA | ILENYDF. |
| PhylomeDB | O05218. |
Enzyme and pathway databases | |
| BioCyc | SUBTI:BSU36100-MONOMER. |
Family and domain databases | |
| InterPro | IPR000101. GGT_peptidase. [Graphical view] |
| PANTHER | PTHR11686. GGT_peptidase. 1 hit. |
| Pfam | PF01019. G_glu_transpept. 1 hit. [Graphical view] |
| PRINTS | PR01210. GGTRANSPTASE. |
| TIGRFAMs | TIGR00066. g_glut_trans. 1 hit. |
| PROSITE | PS00462. G_GLU_TRANSPEPTIDASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | YWRD_BACSU | ||||||||
| Accession | Primary (citable) accession number: O05218 Secondary accession number(s): Q795C4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| SIMILARITY comments Index of protein domains and families |

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