O05218 (YWRD_BACSU) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 73.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Putative gamma-glutamyltransferase YwrD EC=2.3.2.2 Cleaved into the following 2 chains: | ||||
| Gene names |
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| Organism | Bacillus subtilis (strain 168) [Reference proteome] [HAMAP] | ||||
| Taxonomic identifier | 224308 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › ![]() |
Protein attributes
| Sequence length | 525 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid. Glutathione + H2O = L-cysteinylglycine + L-glutamate. |
| Subunit structure | This enzyme consists of two polypeptide chains, which are synthesized from a single polypeptide By similarity. |
| Induction | Positively regulated by TnrA under nitrogen-limited conditions. Ref.3 |
| Miscellaneous | Is not involved in the utilization of extracellular glutathione as a sulfur source. |
| Sequence similarities | Belongs to the gamma-glutamyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Acyltransferase Hydrolase Transferase |
| PTM | Zymogen |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | glutathione metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular_function | gamma-glutamyltransferase activity Inferred from electronic annotation. Source: EC hydrolase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees)." Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V., Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H., Villani G., Kunst F., Danchin A., Glaser P. Microbiology 143:3313-3328(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [3] | "Identification of additional TnrA-regulated genes of Bacillus subtilis associated with a TnrA box." Yoshida K., Yamaguchi H., Kinehara M., Ohki Y.-H., Nakaura Y., Fujita Y. Mol. Microbiol. 49:157-165(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION BY TNRA. |
| [4] | "Gamma-glutamyltranspeptidase, but not YwrD, is important in utilization of extracellular glutathione as a sulfur source in Bacillus subtilis." Minami H., Suzuki H., Kumagai H. J. Bacteriol. 186:1213-1214(2004) [PubMed] [Europe PMC] [Abstract] Cited for: LACK OF FUNCTION IN GLUTATHIONE METABOLISM. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z93767 Genomic DNA. Translation: CAB07790.1. AL009126 Genomic DNA. Translation: CAB15627.1. |
| PIR | F70068. |
| RefSeq | NP_391491.1. NC_000964.3. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2DG5 based on UniProtKB P18956. |
| ProteinModelPortal | O05218. |
| SMR | O05218. Positions 2-525. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 224308.BSU36100. |
Protein family/group databases | |
| MEROPS | T03.A09. |
Proteomic databases | |
| PaxDb | O05218. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | CAB15627; CAB15627; BSU36100. |
| GeneID | 936884. |
| KEGG | bsu:BSU36100. |
| PATRIC | 18979238. VBIBacSub10457_3781. |
Organism-specific databases | |
| GenoList | BSU36100. |
Phylogenomic databases | |
| eggNOG | COG0405. |
| HOGENOM | HOG000175618. |
| KO | K00681. |
| OMA | NAVSFIQ. |
| ProtClustDB | CLSK888003. |
Enzyme and pathway databases | |
| BioCyc | BSUB:BSU36100-MONOMER. |
Family and domain databases | |
| InterPro | IPR000101. GGT_peptidase. [Graphical view] |
| PANTHER | PTHR11686. PTHR11686. 1 hit. |
| Pfam | PF01019. G_glu_transpept. 1 hit. [Graphical view] |
| PRINTS | PR01210. GGTRANSPTASE. |
| TIGRFAMs | TIGR00066. g_glut_trans. 1 hit. |
| PROSITE | PS00462. G_GLU_TRANSPEPTIDASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | YWRD_BACSU | ||||||||
| Accession | Primary (citable) accession number: O05218 Secondary accession number(s): Q795C4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| SIMILARITY comments Index of protein domains and families |

Clusters with
