Reviewed,
UniProtKB/Swiss-Prot O05100 (DEF1_CLOAB)
Last modified
November 3, 2009.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Peptide deformylase 1 Short name=PDF 1 EC=3.5.1.88 Alternative name(s): Polypeptide deformylase 1 | ||||
| Gene names |
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| Organism | Clostridium acetobutylicum [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1488 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium |
Protein attributes
| Sequence length | 150 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. |
| Catalytic activity | Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP MF_00163 |
| Cofactor | Binds 1 Fe2+ ion By similarity. |
| Sequence similarities | Belongs to the polypeptide deformylase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein biosynthesis |
| Ligand | Iron Metal-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | translation Inferred from electronic annotation. Source: HAMAP |
| Molecular function | iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW peptide deformylase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complementation of an Escherichia coli polypeptide deformylase mutant with a gene from Clostridium acetobutylicum ATCC 824." Belouski E., Gui L., Rudolph F.B., Bennett G.N. Curr. Microbiol. 36:248-249(1998) [PubMed: 9504995] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787. |
| [2] | "Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum." Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R. J. Bacteriol. 183:4823-4838(2001) [PubMed: 11466286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787. |
Cross-references
Sequence databases | |
|---|---|
| U52368 Genomic DNA. Translation: AAB50347.1. AE001437 Genomic DNA. Translation: AAK79688.1. | |
| PIR | E97112. |
| RefSeq | NP_348348.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1LME based on UniProtKB P96113. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1117905. |
| GenomeReviews | Gene locus CA_C1722 in contig AE001437_GR. |
| KEGG | cac:CAC1722. |
| NMPDR | fig|272562.1.peg.1877. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | O05100. |
| OMA | IIMHEND. |
Enzyme and pathway databases | |
| BioCyc | CACE272562:CAC1722-MON. |
| BRENDA | 3.5.1.88. 2866. |
Family and domain databases | |
| HAMAP | MF_00163. [Tree] |
| InterPro | IPR000181. Fmet_deformylase. [Graphical view] |
| Gene3D | G3DSA:3.90.45.10. Fmet_deformylase. 1 hit. |
| PANTHER | PTHR10458. Fmet_deformylase. 1 hit. |
| Pfam | PF01327. Pep_deformylase. 1 hit. [Graphical view] |
| PIRSF | PIRSF004749. Pep_def. 1 hit. |
| PRINTS | PR01576. PDEFORMYLASE. |
| ProDom | PD003844. Fmet_deformylase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00079. pept_deformyl. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | DEF1_CLOAB | ||||||||
| Accession | Primary (citable) accession number: O05100 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

Clusters with


