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Protein

ATP synthase subunit a

Gene

atpB

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciCACE272562:GJIH-2954-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit aUniRule annotation
Alternative name(s):
ATP synthase F0 sector subunit aUniRule annotation
F-ATPase subunit 6UniRule annotation
Gene namesi
Name:atpBUniRule annotation
Synonyms:atpA
Ordered Locus Names:CA_C2871
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalUniRule annotationAdd
BLAST
Transmembranei78 – 9821HelicalUniRule annotationAdd
BLAST
Transmembranei106 – 12621HelicalUniRule annotationAdd
BLAST
Transmembranei158 – 17821HelicalUniRule annotationAdd
BLAST
Transmembranei194 – 21421HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, CF(0), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221ATP synthase subunit aPRO_0000082052Add
BLAST

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

Protein-protein interaction databases

STRINGi272562.CA_C2871.

Structurei

3D structure databases

ProteinModelPortaliO05097.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase A chain family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107RFS. Bacteria.
COG0356. LUCA.
HOGENOMiHOG000253873.
KOiK02108.
OMAiTIMELIY.
OrthoDBiEOG6K4054.

Family and domain databases

Gene3Di1.20.120.220. 1 hit.
HAMAPiMF_01393. ATP_synth_a_bact.
InterProiIPR000568. ATPase_F0-cplx_asu.
[Graphical view]
PANTHERiPTHR11410. PTHR11410. 1 hit.
PfamiPF00119. ATP-synt_A. 1 hit.
[Graphical view]
PRINTSiPR00123. ATPASEA.
SUPFAMiSSF81336. SSF81336. 1 hit.

Sequencei

Sequence statusi: Complete.

O05097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGAKTVFS MKLGSYNFAI TETVVLQWII MAVIILLAIF LTKNLKKVPN
60 70 80 90 100
RKQSVIEMIV NLINGLVKEN MGEKFMNFVP IIGTMAVFIL FLNLTGLVGI
110 120 130 140 150
EPATKDISVT AGFALVSAFL INATAIKRIG VGGYIKSIFS QGPIMVPMNL
160 170 180 190 200
LEKVTIPVSL CLRLFINMLV GAIVMSLIYS TPAKILLPVP LHGFFDMFDG
210 220
VLQVYVFVLL TMIFTKLGIE H
Length:221
Mass (Da):24,316
Last modified:July 1, 1997 - v1
Checksum:i391D05175396C3EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52367 Genomic DNA. Translation: AAB50191.1.
AF101055 Genomic DNA. Translation: AAD16420.1.
AE001437 Genomic DNA. Translation: AAK80814.1.
PIRiC97253.
RefSeqiNP_349474.1. NC_003030.1.
WP_010966155.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK80814; AAK80814; CA_C2871.
GeneIDi1119054.
KEGGicac:CA_C2871.
PATRICi32040153. VBICloAce74127_3055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52367 Genomic DNA. Translation: AAB50191.1.
AF101055 Genomic DNA. Translation: AAD16420.1.
AE001437 Genomic DNA. Translation: AAK80814.1.
PIRiC97253.
RefSeqiNP_349474.1. NC_003030.1.
WP_010966155.1. NC_003030.1.

3D structure databases

ProteinModelPortaliO05097.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272562.CA_C2871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK80814; AAK80814; CA_C2871.
GeneIDi1119054.
KEGGicac:CA_C2871.
PATRICi32040153. VBICloAce74127_3055.

Phylogenomic databases

eggNOGiENOG4107RFS. Bacteria.
COG0356. LUCA.
HOGENOMiHOG000253873.
KOiK02108.
OMAiTIMELIY.
OrthoDBiEOG6K4054.

Enzyme and pathway databases

BioCyciCACE272562:GJIH-2954-MONOMER.

Family and domain databases

Gene3Di1.20.120.220. 1 hit.
HAMAPiMF_01393. ATP_synth_a_bact.
InterProiIPR000568. ATPase_F0-cplx_asu.
[Graphical view]
PANTHERiPTHR11410. PTHR11410. 1 hit.
PfamiPF00119. ATP-synt_A. 1 hit.
[Graphical view]
PRINTSiPR00123. ATPASEA.
SUPFAMiSSF81336. SSF81336. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of the F0 structural subunits a, c, and b of the F-type ATP synthases from Clostridium acetobutylicum."
    Belouski E., Bennett G.N.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  2. "Sequence analysis of the atp operon of Clostridium acetobutylicum DSM 792 encoding the F0F1 ATP synthase."
    Externbrink T., Hujer S., Winzer K., Duerre P.
    DNA Seq. 11:109-118(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Entry informationi

Entry nameiATP6_CLOAB
AccessioniPrimary (citable) accession number: O05097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: November 11, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.