Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O05052

- T1RH_HAEIN

UniProt

O05052 - T1RH_HAEIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Putative type I restriction enzyme HindVIIP R protein

Gene

HI_1285

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Subunit R is required for both nuclease and ATPase activities, but not for modification.By similarity

Catalytic activityi

Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. Type I site-specific deoxyribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Protein family/group databases

REBASEi1149. HindI.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type I restriction enzyme HindVIIP R protein (EC:3.1.21.3)
Gene namesi
Ordered Locus Names:HI_1285
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10551055Putative type I restriction enzyme HindVIIP R proteinPRO_0000077262Add
BLAST

Interactioni

Subunit structurei

The type I restriction/modification system is composed of three polypeptides R, M and S.By similarity

Protein-protein interaction databases

STRINGi71421.HI1285.

Structurei

3D structure databases

ProteinModelPortaliO05052.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini287 – 468182Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the HsdR family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0610.
KOiK01153.
OMAiIRYFVLF.
OrthoDBiEOG62G5HP.
PhylomeDBiO05052.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR021810. DUF3387.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR007409. Restrct_endonuc_type1_HsdR_N.
IPR004473. Restrct_endonuc_typeI_HsdR.
[Graphical view]
PfamiPF11867. DUF3387. 1 hit.
PF04313. HSDR_N. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00348. hsdR. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O05052-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNENDIEQL TLQRLQSLGW EYRYGKDLPV HEGKFARGDL SGVVFVEQLR
60 70 80 90 100
EAVRKLNPQL PESAVDSVVK SATKSDIGDL VVRNQTFYKL LRDGVRVEYT
110 120 130 140 150
QNGEQKIEMV RLVDFEHWGN NRFVAVNQLE IRSRKGGKRI PDIIGFVNGL
160 170 180 190 200
PLVVFELKNP LRESADLLQA FNQFETYKDE IAELFVYNQA LIISDGIVAR
210 220 230 240 250
LGSLSADFQR FTPWKVVDEK NKSARLYFDD ELQSLLNGLM QPEDLLDYIR
260 270 280 290 300
YFVLFERDSV GKTIKKIAAY HQYYGVNEAV DSTIWATSEK GDRRIGVMWH
310 320 330 340 350
TQGSGKSISM LFYAGKLLAQ PELKNPTIVV VTDRNDLDGQ LFQTFSSGKD
360 370 380 390 400
LIKQTPQQVE DRDQLRQLLA QNEVGGVFFT TIQKFALNEE ESRFPILNER
410 420 430 440 450
NNIIVISDEA HRSQYGFTQK LHNGKFQTGY ARHLRDALPN ASFIGFTGTP
460 470 480 490 500
ISLEDKDTQD VFGRYVSIYD LQDAVEDGAT VPIVYDDARQ IRLNKKDHDA
510 520 530 540 550
LFAEIDALLE EEPSTSLRLR EKLLGSQERL IELAADFVQH FAKRNEVVDS
560 570 580 590 600
KAMMVVSSRQ ICVDLYNQII ALHPEWHSDN INEGAIKIVM TGSASDTPEM
610 620 630 640 650
QKHIYSKQEK QTLERRFKDP NDPLKVVIVR DMWLTGFDAP CCNTMYLDKP
660 670 680 690 700
MKGHNLMQAI ARVNRVFANK SRENGGLIVD YVGLAKELRA ATQQYTNSTG
710 720 730 740 750
KGQLAEDVQS VFFKMKEQLE FIRTLFATPI EGKTFDVQAA LEKDNPNDLL
760 770 780 790 800
MAIRFAANHI LSLDQLSFDG KAHEQHWFNK KETEPRKKAF LKTAGLVKKG
810 820 830 840 850
YMLCGTLAEV EPYNQEIAFY DAVRAILTKR EQKGTGTNER QILLKKLVNQ
860 870 880 890 900
TVYSEGVIDL FDLLEKPQPQ ISLLSEEFLQ TVKNSPTKNL WVSAMERYLA
910 920 930 940 950
SEIKVKSGTN LTLQKDFERR LKEALNQYHN HNLTVVEILD ELFKMSQDFQ
960 970 980 990 1000
ERLALGKKLG LTKEELAFYE ALSQNQSAKD LMGDEVLSKL AKEITETLRK
1010 1020 1030 1040 1050
SVTIDWQYKE AVRARIRLLV RRALQKYKYP PDKQEEAVTY VIKQAEEIAE

DLTGL
Length:1,055
Mass (Da):120,710
Last modified:July 1, 1997 - v1
Checksum:iC5BEF298E7E05C67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22934.1.
PIRiF64114.
RefSeqiNP_439437.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22934; AAC22934; HI_1285.
GeneIDi950228.
KEGGihin:HI1285.
PATRICi20191253. VBIHaeInf48452_1337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22934.1 .
PIRi F64114.
RefSeqi NP_439437.1. NC_000907.1.

3D structure databases

ProteinModelPortali O05052.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1285.

Protein family/group databases

REBASEi 1149. HindI.

Protocols and materials databases

DNASUi 950228.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22934 ; AAC22934 ; HI_1285 .
GeneIDi 950228.
KEGGi hin:HI1285.
PATRICi 20191253. VBIHaeInf48452_1337.

Phylogenomic databases

eggNOGi COG0610.
KOi K01153.
OMAi IRYFVLF.
OrthoDBi EOG62G5HP.
PhylomeDBi O05052.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR021810. DUF3387.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR007409. Restrct_endonuc_type1_HsdR_N.
IPR004473. Restrct_endonuc_typeI_HsdR.
[Graphical view ]
Pfami PF11867. DUF3387. 1 hit.
PF04313. HSDR_N. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00348. hsdR. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiT1RH_HAEIN
AccessioniPrimary (citable) accession number: O05052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: October 1, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3