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Protein

Putative type I restriction enzyme HindVIIP R protein

Gene

HI_1285

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Subunit R is required for both nuclease and ATPase activities, but not for modification.By similarity

Catalytic activityi

Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Protein family/group databases

REBASEi1149. HindI.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type I restriction enzyme HindVIIP R protein (EC:3.1.21.3)
Gene namesi
Ordered Locus Names:HI_1285
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10551055Putative type I restriction enzyme HindVIIP R proteinPRO_0000077262Add
BLAST

Interactioni

Subunit structurei

The type I restriction/modification system is composed of three polypeptides R, M and S.By similarity

Protein-protein interaction databases

STRINGi71421.HI1285.

Structurei

3D structure databases

ProteinModelPortaliO05052.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini287 – 468182Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the HsdR family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0610.
KOiK01153.
OMAiNDWLAVN.
OrthoDBiEOG62G5HP.
PhylomeDBiO05052.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR021810. DUF3387.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR007409. Restrct_endonuc_type1_HsdR_N.
IPR004473. Restrct_endonuc_typeI_HsdR.
[Graphical view]
PfamiPF11867. DUF3387. 1 hit.
PF04313. HSDR_N. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00348. hsdR. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O05052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNENDIEQL TLQRLQSLGW EYRYGKDLPV HEGKFARGDL SGVVFVEQLR
60 70 80 90 100
EAVRKLNPQL PESAVDSVVK SATKSDIGDL VVRNQTFYKL LRDGVRVEYT
110 120 130 140 150
QNGEQKIEMV RLVDFEHWGN NRFVAVNQLE IRSRKGGKRI PDIIGFVNGL
160 170 180 190 200
PLVVFELKNP LRESADLLQA FNQFETYKDE IAELFVYNQA LIISDGIVAR
210 220 230 240 250
LGSLSADFQR FTPWKVVDEK NKSARLYFDD ELQSLLNGLM QPEDLLDYIR
260 270 280 290 300
YFVLFERDSV GKTIKKIAAY HQYYGVNEAV DSTIWATSEK GDRRIGVMWH
310 320 330 340 350
TQGSGKSISM LFYAGKLLAQ PELKNPTIVV VTDRNDLDGQ LFQTFSSGKD
360 370 380 390 400
LIKQTPQQVE DRDQLRQLLA QNEVGGVFFT TIQKFALNEE ESRFPILNER
410 420 430 440 450
NNIIVISDEA HRSQYGFTQK LHNGKFQTGY ARHLRDALPN ASFIGFTGTP
460 470 480 490 500
ISLEDKDTQD VFGRYVSIYD LQDAVEDGAT VPIVYDDARQ IRLNKKDHDA
510 520 530 540 550
LFAEIDALLE EEPSTSLRLR EKLLGSQERL IELAADFVQH FAKRNEVVDS
560 570 580 590 600
KAMMVVSSRQ ICVDLYNQII ALHPEWHSDN INEGAIKIVM TGSASDTPEM
610 620 630 640 650
QKHIYSKQEK QTLERRFKDP NDPLKVVIVR DMWLTGFDAP CCNTMYLDKP
660 670 680 690 700
MKGHNLMQAI ARVNRVFANK SRENGGLIVD YVGLAKELRA ATQQYTNSTG
710 720 730 740 750
KGQLAEDVQS VFFKMKEQLE FIRTLFATPI EGKTFDVQAA LEKDNPNDLL
760 770 780 790 800
MAIRFAANHI LSLDQLSFDG KAHEQHWFNK KETEPRKKAF LKTAGLVKKG
810 820 830 840 850
YMLCGTLAEV EPYNQEIAFY DAVRAILTKR EQKGTGTNER QILLKKLVNQ
860 870 880 890 900
TVYSEGVIDL FDLLEKPQPQ ISLLSEEFLQ TVKNSPTKNL WVSAMERYLA
910 920 930 940 950
SEIKVKSGTN LTLQKDFERR LKEALNQYHN HNLTVVEILD ELFKMSQDFQ
960 970 980 990 1000
ERLALGKKLG LTKEELAFYE ALSQNQSAKD LMGDEVLSKL AKEITETLRK
1010 1020 1030 1040 1050
SVTIDWQYKE AVRARIRLLV RRALQKYKYP PDKQEEAVTY VIKQAEEIAE

DLTGL
Length:1,055
Mass (Da):120,710
Last modified:July 1, 1997 - v1
Checksum:iC5BEF298E7E05C67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22934.1.
PIRiF64114.
RefSeqiNP_439437.1. NC_000907.1.
WP_005694526.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22934; AAC22934; HI_1285.
GeneIDi950228.
KEGGihin:HI1285.
PATRICi20191253. VBIHaeInf48452_1337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22934.1.
PIRiF64114.
RefSeqiNP_439437.1. NC_000907.1.
WP_005694526.1. NC_000907.1.

3D structure databases

ProteinModelPortaliO05052.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1285.

Protein family/group databases

REBASEi1149. HindI.

Protocols and materials databases

DNASUi950228.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22934; AAC22934; HI_1285.
GeneIDi950228.
KEGGihin:HI1285.
PATRICi20191253. VBIHaeInf48452_1337.

Phylogenomic databases

eggNOGiCOG0610.
KOiK01153.
OMAiNDWLAVN.
OrthoDBiEOG62G5HP.
PhylomeDBiO05052.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR021810. DUF3387.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR007409. Restrct_endonuc_type1_HsdR_N.
IPR004473. Restrct_endonuc_typeI_HsdR.
[Graphical view]
PfamiPF11867. DUF3387. 1 hit.
PF04313. HSDR_N. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00348. hsdR. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiT1RH_HAEIN
AccessioniPrimary (citable) accession number: O05052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: July 22, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.