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O05052

- T1RH_HAEIN

UniProt

O05052 - T1RH_HAEIN

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Protein

Putative type I restriction enzyme HindVIIP R protein

Gene
HI_1285
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Subunit R is required for both nuclease and ATPase activities, but not for modification By similarity.

Catalytic activityi

Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. Type I site-specific deoxyribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Protein family/group databases

REBASEi1149. HindI.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type I restriction enzyme HindVIIP R protein (EC:3.1.21.3)
Gene namesi
Ordered Locus Names:HI_1285
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10551055Putative type I restriction enzyme HindVIIP R proteinPRO_0000077262Add
BLAST

Interactioni

Subunit structurei

The type I restriction/modification system is composed of three polypeptides R, M and S By similarity.

Protein-protein interaction databases

STRINGi71421.HI1285.

Structurei

3D structure databases

ProteinModelPortaliO05052.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini287 – 468182Helicase ATP-bindingAdd
BLAST

Sequence similaritiesi

Belongs to the HsdR family.

Phylogenomic databases

eggNOGiCOG0610.
KOiK01153.
OMAiIRYFVLF.
OrthoDBiEOG62G5HP.
PhylomeDBiO05052.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR021810. DUF3387.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR007409. Restrct_endonuc_type1_HsdR_N.
IPR004473. Restrct_endonuc_typeI_HsdR.
[Graphical view]
PfamiPF11867. DUF3387. 1 hit.
PF04313. HSDR_N. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00348. hsdR. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O05052-1 [UniParc]FASTAAdd to Basket

« Hide

MLNENDIEQL TLQRLQSLGW EYRYGKDLPV HEGKFARGDL SGVVFVEQLR     50
EAVRKLNPQL PESAVDSVVK SATKSDIGDL VVRNQTFYKL LRDGVRVEYT 100
QNGEQKIEMV RLVDFEHWGN NRFVAVNQLE IRSRKGGKRI PDIIGFVNGL 150
PLVVFELKNP LRESADLLQA FNQFETYKDE IAELFVYNQA LIISDGIVAR 200
LGSLSADFQR FTPWKVVDEK NKSARLYFDD ELQSLLNGLM QPEDLLDYIR 250
YFVLFERDSV GKTIKKIAAY HQYYGVNEAV DSTIWATSEK GDRRIGVMWH 300
TQGSGKSISM LFYAGKLLAQ PELKNPTIVV VTDRNDLDGQ LFQTFSSGKD 350
LIKQTPQQVE DRDQLRQLLA QNEVGGVFFT TIQKFALNEE ESRFPILNER 400
NNIIVISDEA HRSQYGFTQK LHNGKFQTGY ARHLRDALPN ASFIGFTGTP 450
ISLEDKDTQD VFGRYVSIYD LQDAVEDGAT VPIVYDDARQ IRLNKKDHDA 500
LFAEIDALLE EEPSTSLRLR EKLLGSQERL IELAADFVQH FAKRNEVVDS 550
KAMMVVSSRQ ICVDLYNQII ALHPEWHSDN INEGAIKIVM TGSASDTPEM 600
QKHIYSKQEK QTLERRFKDP NDPLKVVIVR DMWLTGFDAP CCNTMYLDKP 650
MKGHNLMQAI ARVNRVFANK SRENGGLIVD YVGLAKELRA ATQQYTNSTG 700
KGQLAEDVQS VFFKMKEQLE FIRTLFATPI EGKTFDVQAA LEKDNPNDLL 750
MAIRFAANHI LSLDQLSFDG KAHEQHWFNK KETEPRKKAF LKTAGLVKKG 800
YMLCGTLAEV EPYNQEIAFY DAVRAILTKR EQKGTGTNER QILLKKLVNQ 850
TVYSEGVIDL FDLLEKPQPQ ISLLSEEFLQ TVKNSPTKNL WVSAMERYLA 900
SEIKVKSGTN LTLQKDFERR LKEALNQYHN HNLTVVEILD ELFKMSQDFQ 950
ERLALGKKLG LTKEELAFYE ALSQNQSAKD LMGDEVLSKL AKEITETLRK 1000
SVTIDWQYKE AVRARIRLLV RRALQKYKYP PDKQEEAVTY VIKQAEEIAE 1050
DLTGL 1055
Length:1,055
Mass (Da):120,710
Last modified:July 1, 1997 - v1
Checksum:iC5BEF298E7E05C67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22934.1.
PIRiF64114.
RefSeqiNP_439437.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22934; AAC22934; HI_1285.
GeneIDi950228.
KEGGihin:HI1285.
PATRICi20191253. VBIHaeInf48452_1337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22934.1 .
PIRi F64114.
RefSeqi NP_439437.1. NC_000907.1.

3D structure databases

ProteinModelPortali O05052.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1285.

Protein family/group databases

REBASEi 1149. HindI.

Protocols and materials databases

DNASUi 950228.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22934 ; AAC22934 ; HI_1285 .
GeneIDi 950228.
KEGGi hin:HI1285.
PATRICi 20191253. VBIHaeInf48452_1337.

Phylogenomic databases

eggNOGi COG0610.
KOi K01153.
OMAi IRYFVLF.
OrthoDBi EOG62G5HP.
PhylomeDBi O05052.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR021810. DUF3387.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR007409. Restrct_endonuc_type1_HsdR_N.
IPR004473. Restrct_endonuc_typeI_HsdR.
[Graphical view ]
Pfami PF11867. DUF3387. 1 hit.
PF04313. HSDR_N. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00348. hsdR. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiT1RH_HAEIN
AccessioniPrimary (citable) accession number: O05052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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