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O05052 (T1RH_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative type I restriction enzyme HindVIIP R protein

EC=3.1.21.3
Gene names
Ordered Locus Names:HI_1285
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length1055 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunit R is required for both nuclease and ATPase activities, but not for modification By similarity.

Catalytic activity

Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed.

Subunit structure

The type I restriction/modification system is composed of three polypeptides R, M and S By similarity.

Sequence similarities

Belongs to the HsdR family.

Contains 1 helicase ATP-binding domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10551055Putative type I restriction enzyme HindVIIP R protein
PRO_0000077262

Regions

Domain287 – 468182Helicase ATP-binding

Sequences

Sequence LengthMass (Da)Tools
O05052 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: C5BEF298E7E05C67

FASTA1,055120,710
        10         20         30         40         50         60 
MLNENDIEQL TLQRLQSLGW EYRYGKDLPV HEGKFARGDL SGVVFVEQLR EAVRKLNPQL 

        70         80         90        100        110        120 
PESAVDSVVK SATKSDIGDL VVRNQTFYKL LRDGVRVEYT QNGEQKIEMV RLVDFEHWGN 

       130        140        150        160        170        180 
NRFVAVNQLE IRSRKGGKRI PDIIGFVNGL PLVVFELKNP LRESADLLQA FNQFETYKDE 

       190        200        210        220        230        240 
IAELFVYNQA LIISDGIVAR LGSLSADFQR FTPWKVVDEK NKSARLYFDD ELQSLLNGLM 

       250        260        270        280        290        300 
QPEDLLDYIR YFVLFERDSV GKTIKKIAAY HQYYGVNEAV DSTIWATSEK GDRRIGVMWH 

       310        320        330        340        350        360 
TQGSGKSISM LFYAGKLLAQ PELKNPTIVV VTDRNDLDGQ LFQTFSSGKD LIKQTPQQVE 

       370        380        390        400        410        420 
DRDQLRQLLA QNEVGGVFFT TIQKFALNEE ESRFPILNER NNIIVISDEA HRSQYGFTQK 

       430        440        450        460        470        480 
LHNGKFQTGY ARHLRDALPN ASFIGFTGTP ISLEDKDTQD VFGRYVSIYD LQDAVEDGAT 

       490        500        510        520        530        540 
VPIVYDDARQ IRLNKKDHDA LFAEIDALLE EEPSTSLRLR EKLLGSQERL IELAADFVQH 

       550        560        570        580        590        600 
FAKRNEVVDS KAMMVVSSRQ ICVDLYNQII ALHPEWHSDN INEGAIKIVM TGSASDTPEM 

       610        620        630        640        650        660 
QKHIYSKQEK QTLERRFKDP NDPLKVVIVR DMWLTGFDAP CCNTMYLDKP MKGHNLMQAI 

       670        680        690        700        710        720 
ARVNRVFANK SRENGGLIVD YVGLAKELRA ATQQYTNSTG KGQLAEDVQS VFFKMKEQLE 

       730        740        750        760        770        780 
FIRTLFATPI EGKTFDVQAA LEKDNPNDLL MAIRFAANHI LSLDQLSFDG KAHEQHWFNK 

       790        800        810        820        830        840 
KETEPRKKAF LKTAGLVKKG YMLCGTLAEV EPYNQEIAFY DAVRAILTKR EQKGTGTNER 

       850        860        870        880        890        900 
QILLKKLVNQ TVYSEGVIDL FDLLEKPQPQ ISLLSEEFLQ TVKNSPTKNL WVSAMERYLA 

       910        920        930        940        950        960 
SEIKVKSGTN LTLQKDFERR LKEALNQYHN HNLTVVEILD ELFKMSQDFQ ERLALGKKLG 

       970        980        990       1000       1010       1020 
LTKEELAFYE ALSQNQSAKD LMGDEVLSKL AKEITETLRK SVTIDWQYKE AVRARIRLLV 

      1030       1040       1050 
RRALQKYKYP PDKQEEAVTY VIKQAEEIAE DLTGL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22934.1.
PIRF64114.
RefSeqNP_439437.1. NC_000907.1.

3D structure databases

ProteinModelPortalO05052.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1285.

Protein family/group databases

REBASE1149. HindI.

Protocols and materials databases

DNASU950228.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22934; AAC22934; HI_1285.
GeneID950228.
KEGGhin:HI1285.
PATRIC20191253. VBIHaeInf48452_1337.

Phylogenomic databases

eggNOGCOG0610.
KOK01153.
OMAENRTPEL.
OrthoDBEOG62G5HP.
ProtClustDBCLSK808504.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR021810. DUF3387.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
IPR007409. Restrct_endonuc_type1_HsdR_N.
IPR004473. Restrct_endonuc_typeI_HsdR.
[Graphical view]
PfamPF11867. DUF3387. 1 hit.
PF04313. HSDR_N. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
TIGRFAMsTIGR00348. hsdR. 1 hit.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameT1RH_HAEIN
AccessionPrimary (citable) accession number: O05052
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names