Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O05052

- T1RH_HAEIN

UniProt

O05052 - T1RH_HAEIN

Protein

Putative type I restriction enzyme HindVIIP R protein

Gene

HI_1285

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Subunit R is required for both nuclease and ATPase activities, but not for modification.By similarity

    Catalytic activityi

    Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. Type I site-specific deoxyribonuclease activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Protein family/group databases

    REBASEi1149. HindI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative type I restriction enzyme HindVIIP R protein (EC:3.1.21.3)
    Gene namesi
    Ordered Locus Names:HI_1285
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10551055Putative type I restriction enzyme HindVIIP R proteinPRO_0000077262Add
    BLAST

    Interactioni

    Subunit structurei

    The type I restriction/modification system is composed of three polypeptides R, M and S.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI1285.

    Structurei

    3D structure databases

    ProteinModelPortaliO05052.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini287 – 468182Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HsdR family.Curated
    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0610.
    KOiK01153.
    OMAiIRYFVLF.
    OrthoDBiEOG62G5HP.
    PhylomeDBiO05052.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR021810. DUF3387.
    IPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR027417. P-loop_NTPase.
    IPR007409. Restrct_endonuc_type1_HsdR_N.
    IPR004473. Restrct_endonuc_typeI_HsdR.
    [Graphical view]
    PfamiPF11867. DUF3387. 1 hit.
    PF04313. HSDR_N. 1 hit.
    PF04851. ResIII. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 3 hits.
    TIGRFAMsiTIGR00348. hsdR. 1 hit.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O05052-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNENDIEQL TLQRLQSLGW EYRYGKDLPV HEGKFARGDL SGVVFVEQLR     50
    EAVRKLNPQL PESAVDSVVK SATKSDIGDL VVRNQTFYKL LRDGVRVEYT 100
    QNGEQKIEMV RLVDFEHWGN NRFVAVNQLE IRSRKGGKRI PDIIGFVNGL 150
    PLVVFELKNP LRESADLLQA FNQFETYKDE IAELFVYNQA LIISDGIVAR 200
    LGSLSADFQR FTPWKVVDEK NKSARLYFDD ELQSLLNGLM QPEDLLDYIR 250
    YFVLFERDSV GKTIKKIAAY HQYYGVNEAV DSTIWATSEK GDRRIGVMWH 300
    TQGSGKSISM LFYAGKLLAQ PELKNPTIVV VTDRNDLDGQ LFQTFSSGKD 350
    LIKQTPQQVE DRDQLRQLLA QNEVGGVFFT TIQKFALNEE ESRFPILNER 400
    NNIIVISDEA HRSQYGFTQK LHNGKFQTGY ARHLRDALPN ASFIGFTGTP 450
    ISLEDKDTQD VFGRYVSIYD LQDAVEDGAT VPIVYDDARQ IRLNKKDHDA 500
    LFAEIDALLE EEPSTSLRLR EKLLGSQERL IELAADFVQH FAKRNEVVDS 550
    KAMMVVSSRQ ICVDLYNQII ALHPEWHSDN INEGAIKIVM TGSASDTPEM 600
    QKHIYSKQEK QTLERRFKDP NDPLKVVIVR DMWLTGFDAP CCNTMYLDKP 650
    MKGHNLMQAI ARVNRVFANK SRENGGLIVD YVGLAKELRA ATQQYTNSTG 700
    KGQLAEDVQS VFFKMKEQLE FIRTLFATPI EGKTFDVQAA LEKDNPNDLL 750
    MAIRFAANHI LSLDQLSFDG KAHEQHWFNK KETEPRKKAF LKTAGLVKKG 800
    YMLCGTLAEV EPYNQEIAFY DAVRAILTKR EQKGTGTNER QILLKKLVNQ 850
    TVYSEGVIDL FDLLEKPQPQ ISLLSEEFLQ TVKNSPTKNL WVSAMERYLA 900
    SEIKVKSGTN LTLQKDFERR LKEALNQYHN HNLTVVEILD ELFKMSQDFQ 950
    ERLALGKKLG LTKEELAFYE ALSQNQSAKD LMGDEVLSKL AKEITETLRK 1000
    SVTIDWQYKE AVRARIRLLV RRALQKYKYP PDKQEEAVTY VIKQAEEIAE 1050
    DLTGL 1055
    Length:1,055
    Mass (Da):120,710
    Last modified:July 1, 1997 - v1
    Checksum:iC5BEF298E7E05C67
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22934.1.
    PIRiF64114.
    RefSeqiNP_439437.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22934; AAC22934; HI_1285.
    GeneIDi950228.
    KEGGihin:HI1285.
    PATRICi20191253. VBIHaeInf48452_1337.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22934.1 .
    PIRi F64114.
    RefSeqi NP_439437.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali O05052.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1285.

    Protein family/group databases

    REBASEi 1149. HindI.

    Protocols and materials databases

    DNASUi 950228.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22934 ; AAC22934 ; HI_1285 .
    GeneIDi 950228.
    KEGGi hin:HI1285.
    PATRICi 20191253. VBIHaeInf48452_1337.

    Phylogenomic databases

    eggNOGi COG0610.
    KOi K01153.
    OMAi IRYFVLF.
    OrthoDBi EOG62G5HP.
    PhylomeDBi O05052.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR021810. DUF3387.
    IPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR027417. P-loop_NTPase.
    IPR007409. Restrct_endonuc_type1_HsdR_N.
    IPR004473. Restrct_endonuc_typeI_HsdR.
    [Graphical view ]
    Pfami PF11867. DUF3387. 1 hit.
    PF04313. HSDR_N. 1 hit.
    PF04851. ResIII. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 3 hits.
    TIGRFAMsi TIGR00348. hsdR. 1 hit.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiT1RH_HAEIN
    AccessioniPrimary (citable) accession number: O05052
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3