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Protein

Non-symbiotic hemoglobin 1

Gene

HB1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May not function as an oxygen storage or transport protein, but might act as an oxygen sensor or play a role in electron transfer, possibly to a bound oxygen molecule. Has an unusually high affinity for O2 because of a very low dissociation constant.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi74Iron (heme distal ligand)1
Metal bindingi109Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-19374

Names & Taxonomyi

Protein namesi
Recommended name:
Non-symbiotic hemoglobin 1
Alternative name(s):
ORYsa GLB1a
rHb1
Gene namesi
Name:HB1
Synonyms:GLB1A
Ordered Locus Names:Os03g0233900, LOC_Os03g13140
ORF Names:OJ1175C11.5, OsJ_10047Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 3

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi47V → N: Prevents subunit association, but has little effect on ligand binding. 1 Publication1
Mutagenesisi50S → A: Prevents subunit association, but has little effect on ligand binding. 1 Publication1
Mutagenesisi74H → L: Increases 1000 times the dissociation constant of O(2). 1 Publication1
Mutagenesisi120E → V: Prevents subunit association, but has little effect on ligand binding. 1 Publication1
Mutagenesisi121V → N: Prevents subunit association, but has little effect on ligand binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001930211 – 166Non-symbiotic hemoglobin 1Add BLAST166

Proteomic databases

PaxDbiO04986
PRIDEiO04986

Expressioni

Tissue specificityi

Expressed in coleoptiles, embryos, leaves and roots.

Inductioni

By flooding and etiolating but not by oxidative, nitrosative or hormonal stresses.1 Publication

Gene expression databases

ExpressionAtlasiO04986 baseline and differential
GenevisibleiO04986 OS

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi39947.LOC_Os03g13140.1

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 9Combined sources3
Helixi16 – 29Combined sources14
Helixi30 – 32Combined sources3
Helixi33 – 47Combined sources15
Helixi49 – 53Combined sources5
Turni58 – 60Combined sources3
Helixi65 – 67Combined sources3
Helixi69 – 92Combined sources24
Helixi99 – 111Combined sources13
Helixi116 – 133Combined sources18
Turni136 – 138Combined sources3
Helixi141 – 160Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D8UX-ray2.35A/B1-166[»]
2GNVX-ray2.30A/B2-166[»]
2GNWX-ray2.40A/B2-166[»]
ProteinModelPortaliO04986
SMRiO04986
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO04986

Family & Domainsi

Sequence similaritiesi

Belongs to the plant globin family.Curated

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
HOGENOMiHOG000233101
InParanoidiO04986
OMAiELESAWD
OrthoDBiEOG09360PFS

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR001032 Leghaemoglobin
IPR019824 Leghaemoglobin_Fe_BS
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00188 PLANTGLOBIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit
PS00208 PLANT_GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

O04986-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVEDNNAV AVSFSEEQEA LVLKSWAILK KDSANIALRF FLKIFEVAPS
60 70 80 90 100
ASQMFSFLRN SDVPLEKNPK LKTHAMSVFV MTCEAAAQLR KAGKVTVRDT
110 120 130 140 150
TLKRLGATHL KYGVGDAHFE VVKFALLDTI KEEVPADMWS PAMKSAWSEA
160
YDHLVAAIKQ EMKPAE
Length:166
Mass (Da):18,444
Last modified:July 1, 1997 - v1
Checksum:iC1FE2CA4701682EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76030 mRNA Translation: AAC49883.1
U76029 Genomic DNA Translation: AAC49882.1
AF335504 Genomic DNA Translation: AAK72229.1
AC103891 Genomic DNA Translation: AAM19125.1
DP000009 Genomic DNA Translation: ABF94821.1
AP008209 Genomic DNA Translation: BAF11390.1
AP014959 Genomic DNA Translation: BAS83133.1
CM000140 Genomic DNA Translation: EAZ26180.1
AK064054 mRNA Translation: BAG88986.1
PIRiT04163
RefSeqiXP_015629794.1, XM_015774308.1
UniGeneiOs.80096

Genome annotation databases

EnsemblPlantsiOs03t0233900-01; Os03t0233900-01; Os03g0233900
GeneIDi4332166
GrameneiOs03t0233900-01; Os03t0233900-01; Os03g0233900
KEGGiosa:4332166

Similar proteinsi

Entry informationi

Entry nameiHBL1_ORYSJ
AccessioniPrimary (citable) accession number: O04986
Secondary accession number(s): Q10PH5, Q7G715
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 1, 1997
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health