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O04940

- CDS1_SOLTU

UniProt

O04940 - CDS1_SOLTU

Protein

Phosphatidate cytidylyltransferase

Gene

CDS1

Organism
Solanum tuberosum (Potato)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction.

    Catalytic activityi

    CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00557; UER00614.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidate cytidylyltransferase (EC:2.7.7.41)
    Alternative name(s):
    CDP-DAG synthase
    CDP-DG synthase
    CDP-diacylglycerol synthase
    Short name:
    CDS
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthase
    CTP:phosphatidate cytidylyltransferase
    Gene namesi
    Name:CDS1
    OrganismiSolanum tuberosum (Potato)
    Taxonomic identifieri4113 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
    ProteomesiUP000011115: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Phosphatidate cytidylyltransferasePRO_0000090724Add
    BLAST

    Expressioni

    Tissue specificityi

    Roots and sink leaves.

    Structurei

    3D structure databases

    ProteinModelPortaliO04940.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei246 – 26621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei321 – 34121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi16 – 216Poly-Arg

    Sequence similaritiesi

    Belongs to the CDS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK00981.

    Family and domain databases

    InterProiIPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view]
    PfamiPF01148. CTP_transf_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
    PROSITEiPS01315. CDS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O04940-1 [UniParc]FASTAAdd to Basket

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    MHNDSNSGAP GTPSGRIRRR RGSNEVPPEV VKANGNHLLV NDRSKYKSML    50
    IRAYSSVWMI GGFAFIIYMG HLYIWAMVVV IQIFMAKELF NLLRRAHEDR 100
    HLPGFRLLNW HFFFTAMLFV YGRMLSQRLV NTVTLDKFLY KLVGRFVKYH 150
    MVTCYFFYIA GFMWFILTLK KKMYKYQFSQ YAWTHMILIV VFTQSAFTVA 200
    NIFEGIFWFL LPASLIVIND IAAYFFGFFF GRTPLIKLSP KKTWEGFIGA 250
    SITTIISAFL LANMFGRFQW LTCPRKDLST GWLDCDPGPL FKPEYFTLPE 300
    WFPAWFLSRE IAVLPVQWHA LLLGLFASII APFGGFFASG FKRAFKIKDF 350
    GDSIPGHGGM TDRMDCQMVM AVFAYIYHQS FIVPQNLSIE MILDQIILNL 400
    TFEEQLAVYK KLGQIIQERT FGES 424
    Length:424
    Mass (Da):49,178
    Last modified:July 1, 1997 - v1
    Checksum:i43B556B12F082638
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91909 mRNA. Translation: CAA63004.1.
    PIRiT07366.
    RefSeqiNP_001275147.1. NM_001288218.1.
    UniGeneiStu.194.

    Genome annotation databases

    GeneIDi102597765.
    KEGGisot:102597765.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91909 mRNA. Translation: CAA63004.1 .
    PIRi T07366.
    RefSeqi NP_001275147.1. NM_001288218.1.
    UniGenei Stu.194.

    3D structure databases

    ProteinModelPortali O04940.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102597765.
    KEGGi sot:102597765.

    Phylogenomic databases

    KOi K00981.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00614 .

    Family and domain databases

    InterProi IPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view ]
    Pfami PF01148. CTP_transf_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
    PROSITEi PS01315. CDS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complementary DNAs encoding eukaryotic-type cytidine-5'-diphosphate-diacylglycerol synthases of two plant species."
      Kopka J., Ludewig M., Mueller-Roeber B.
      Plant Physiol. 113:997-1002(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Desiree.
      Tissue: Leaf.

    Entry informationi

    Entry nameiCDS1_SOLTU
    AccessioniPrimary (citable) accession number: O04940
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3