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Protein

Phosphatidate cytidylyltransferase 1

Gene

CDS1

Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction.1 Publication

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.1 Publication

Cofactori

Mg2+By similarityNote: Requires a divalent cation for activity.By similarity

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase 11 Publication (EC:2.7.7.411 Publication)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:CDS11 Publication
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
ProteomesiUP000011115 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 8021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei149 – 16921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei183 – 20321Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei246 – 26621Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei321 – 34121Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei369 – 38921Helical; Name=8Sequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Phosphatidate cytidylyltransferase 1PRO_0000090724Add
BLAST

Expressioni

Tissue specificityi

Roots and sink leaves.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO04940.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 216Poly-ArgSequence Analysis

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO04940.
KOiK00981.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O04940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNDSNSGAP GTPSGRIRRR RGSNEVPPEV VKANGNHLLV NDRSKYKSML
60 70 80 90 100
IRAYSSVWMI GGFAFIIYMG HLYIWAMVVV IQIFMAKELF NLLRRAHEDR
110 120 130 140 150
HLPGFRLLNW HFFFTAMLFV YGRMLSQRLV NTVTLDKFLY KLVGRFVKYH
160 170 180 190 200
MVTCYFFYIA GFMWFILTLK KKMYKYQFSQ YAWTHMILIV VFTQSAFTVA
210 220 230 240 250
NIFEGIFWFL LPASLIVIND IAAYFFGFFF GRTPLIKLSP KKTWEGFIGA
260 270 280 290 300
SITTIISAFL LANMFGRFQW LTCPRKDLST GWLDCDPGPL FKPEYFTLPE
310 320 330 340 350
WFPAWFLSRE IAVLPVQWHA LLLGLFASII APFGGFFASG FKRAFKIKDF
360 370 380 390 400
GDSIPGHGGM TDRMDCQMVM AVFAYIYHQS FIVPQNLSIE MILDQIILNL
410 420
TFEEQLAVYK KLGQIIQERT FGES
Length:424
Mass (Da):49,178
Last modified:July 1, 1997 - v1
Checksum:i43B556B12F082638
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91909 mRNA. Translation: CAA63004.1.
PIRiT07366.
RefSeqiNP_001275147.1. NM_001288218.1.
UniGeneiStu.194.

Genome annotation databases

GeneIDi102597765.
KEGGisot:102597765.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91909 mRNA. Translation: CAA63004.1.
PIRiT07366.
RefSeqiNP_001275147.1. NM_001288218.1.
UniGeneiStu.194.

3D structure databases

ProteinModelPortaliO04940.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102597765.
KEGGisot:102597765.

Phylogenomic databases

InParanoidiO04940.
KOiK00981.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complementary DNAs encoding eukaryotic-type cytidine-5'-diphosphate-diacylglycerol synthases of two plant species."
    Kopka J., Ludewig M., Mueller-Roeber B.
    Plant Physiol. 113:997-1002(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, PATHWAY.
    Strain: cv. Desiree.
    Tissue: Leaf.

Entry informationi

Entry nameiCDS1_SOLTU
AccessioniPrimary (citable) accession number: O04940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: February 4, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.