O04940 (CDS1_SOLTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidate cytidylyltransferase
EC=2.7.7.41

Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase

Gene names

Name:

CDS1

Organism

Solanum tuberosum (Potato)

Taxonomic identifier

4113 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction.
Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Roots and sink leaves.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	Phosphatidate cytidylyltransferase		PRO_0000090724
Regions
	Transmembrane	60 – 80	21	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	206 – 226	21	Helical; Potential
	Transmembrane	246 – 266	21	Helical; Potential
	Transmembrane	321 – 341	21	Helical; Potential
	Compositional bias	16 – 21	6	Poly-Arg

Sequences

	Sequence		Length	Mass (Da)
	O04940 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 43B556B12F082638	FASTA	424	49,178
	10 20 30 40 50 60 MHNDSNSGAP GTPSGRIRRR RGSNEVPPEV VKANGNHLLV NDRSKYKSML IRAYSSVWMI 70 80 90 100 110 120 GGFAFIIYMG HLYIWAMVVV IQIFMAKELF NLLRRAHEDR HLPGFRLLNW HFFFTAMLFV 130 140 150 160 170 180 YGRMLSQRLV NTVTLDKFLY KLVGRFVKYH MVTCYFFYIA GFMWFILTLK KKMYKYQFSQ 190 200 210 220 230 240 YAWTHMILIV VFTQSAFTVA NIFEGIFWFL LPASLIVIND IAAYFFGFFF GRTPLIKLSP 250 260 270 280 290 300 KKTWEGFIGA SITTIISAFL LANMFGRFQW LTCPRKDLST GWLDCDPGPL FKPEYFTLPE 310 320 330 340 350 360 WFPAWFLSRE IAVLPVQWHA LLLGLFASII APFGGFFASG FKRAFKIKDF GDSIPGHGGM 370 380 390 400 410 420 TDRMDCQMVM AVFAYIYHQS FIVPQNLSIE MILDQIILNL TFEEQLAVYK KLGQIIQERT FGES

References

[1]	"Complementary DNAs encoding eukaryotic-type cytidine-5'-diphosphate-diacylglycerol synthases of two plant species." Kopka J., Ludewig M., Mueller-Roeber B. Plant Physiol. 113:997-1002(1997) [PubMed: 9085581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Desiree. Tissue: Leaf.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X91909 mRNA. Translation: CAA63004.1.
PIR	T07366.
3D structure databases
ProteinModelPortal	O04940.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000374. PC_trans. IPR016720. PC_Trfase_euk. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PIRSF	PIRSF018269. PC_trans_euk. 1 hit.
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDS1_SOLTU

Accession

Primary (citable) accession number: O04940

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 1, 1997
Last modified:	May 31, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program