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O04937

- DHEA_NICPL

UniProt

O04937 - DHEA_NICPL

Protein

Glutamate dehydrogenase A

Gene

GDHA

Organism
Nicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei102 – 1021By similarity

    GO - Molecular functioni

    1. glutamate dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular amino acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate dehydrogenase A (EC:1.4.1.3)
    Short name:
    GDH A
    Gene namesi
    Name:GDHA
    OrganismiNicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)
    Taxonomic identifieri4092 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411Glutamate dehydrogenase APRO_0000182750Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO04937.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000185. Glu_DH. 1 hit.
    PRINTSiPR00082. GLFDHDRGNASE.
    SMARTiSM00839. ELFV_dehydrog. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O04937-1 [UniParc]FASTAAdd to Basket

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    MNALAATNRN FRQAARILGL DSKLEKSLLI PFREIKVECT IPKDDGTLVS    50
    YVGFRVQHDN ARGPMKGGIR YHPEVDLDEV NALAQLMTWK TAVADIPYGG 100
    AKGGIGCKPK DLSKSELERL TRVFTQKIHD LIGINTDVPA PDMGTNAQTM 150
    AWILDEYSKF HGHSPAIVTG KPIDLGGSLG REAATGRGVV YATEALLAEY 200
    GKNIKDLTFA IQGFGNVGAW AAKLIHERGG KVIAVSDITG AVKNPNGLDI 250
    PALLNHKEAT GKLIDFSGGD VMNSDEVLTH ECDVLIPCAL GGVLNRENAD 300
    NVKAKFIIEA ANHPTDPEAD EILCKKGIVI LPDIYANAGG VTVSYFEWVQ 350
    NIQGFMWDEE KVNRELRKYM TKAFHNLKNM CQSHNCSLRM GAFTLGVNRV 400
    ARATTLRGWE A 411
    Length:411
    Mass (Da):44,796
    Last modified:July 1, 1997 - v1
    Checksum:i5CCF132AF2103904
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08292 mRNA. Translation: CAA69600.1.
    AJ277949 Genomic DNA. Translation: CAB94836.1.
    PIRiT16981.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08292 mRNA. Translation: CAA69600.1 .
    AJ277949 Genomic DNA. Translation: CAB94836.1 .
    PIRi T16981.

    3D structure databases

    ProteinModelPortali O04937.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000185. Glu_DH. 1 hit.
    PRINTSi PR00082. GLFDHDRGNASE.
    SMARTi SM00839. ELFV_dehydrog. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of two cDNA clones encoding for glutamate dehydrogenase in Nicotiana plumbaginifolia."
      Ficarelli A., Tassi F., Restivo F.M.
      Plant Cell Physiol. 40:339-342(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Leaf.
    2. "Genomic organisation of GDH genes in Nicotiana plumbaginifolia."
      Restivo F.M., Panizzi N., De Monte G., Ficarelli A.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Leaf.

    Entry informationi

    Entry nameiDHEA_NICPL
    AccessioniPrimary (citable) accession number: O04937
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3