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Protein

Phosphatidate cytidylyltransferase 1

Gene

CDS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction.1 Publication

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.1 Publication

Cofactori

Mg2+By similarityNote: Requires a divalent cation for activity.By similarity

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.1 Publication
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase, chloroplastic (ATS1), Glycerol-3-phosphate acyltransferase 1 (GPAT1), Probable glycerol-3-phosphate acyltransferase 3 (GPAT3), Glycerol-3-phosphate acyltransferase 5 (GPAT5), Glycerol-3-phosphate acyltransferase, chloroplastic (AXX17_At1g32940), Probable glycerol-3-phosphate acyltransferase 2 (GPAT2), Glycerol-3-phosphate acyltransferase 7 (GPAT7), Probable glycerol-3-phosphate acyltransferase 8 (GPAT8)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase 3 (LPAT3), 1-acyl-sn-glycerol-3-phosphate acyltransferase 1, chloroplastic (LPAT1), Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 5 (LPAT5), Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 4 (LPAT4), 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 (LPAT2)
  3. Phosphatidate cytidylyltransferase 1 (CDS1), Phosphatidate cytidylyltransferase (AXX17_At1g55730), Phosphatidate cytidylyltransferase 2 (CDS2), Phosphatidate cytidylyltransferase (AXX17_At2g42720), Phosphatidate cytidylyltransferase (AXX17_At4g30920), Phosphatidate cytidylyltransferase (CDS2), Phosphatidate cytidylyltransferase (CDS2), Phosphatidate cytidylyltransferase 3 (CDS3), Phosphatidate cytidylyltransferase 4, chloroplastic (CDS4), Phosphatidate cytidylyltransferase (AXX17_At3g55010), Phosphatidate cytidylyltransferase (AXX17_At4g25970), Phosphatidate cytidylyltransferase 5, chloroplastic (CDS5)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

  • phosphatidate cytidylyltransferase activity Source: TAIR

GO - Biological processi

  • CDP-diacylglycerol biosynthetic process Source: GO_Central
  • developmental vegetative growth Source: TAIR
  • phosphatidylglycerol biosynthetic process Source: GO_Central
  • phospholipid biosynthetic process Source: TAIR

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandMagnesium

Enzyme and pathway databases

BioCyciMetaCyc:AT1G62430-MONOMER
ReactomeiR-ATH-1483148 Synthesis of PG
R-ATH-1483226 Synthesis of PI
UniPathwayiUPA00557; UER00614

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase 11 Publication (EC:2.7.7.411 Publication)
Alternative name(s):
CDP-DAG synthase 1
CDP-DG synthase 1
CDP-diacylglycerol synthase 1
Short name:
CDS1
CDP-diglyceride pyrophosphorylase 1
CDP-diglyceride synthase 1
CTP:phosphatidate cytidylyltransferase 1
Gene namesi
Name:CDS11 Publication
Ordered Locus Names:At1g62430Imported
ORF Names:F24O1.17Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G62430
TAIRilocus:2027144 AT1G62430

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 80Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei102 – 122Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei149 – 169Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei183 – 203Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei321 – 341Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei369 – 389Helical; Name=8Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907231 – 421Phosphatidate cytidylyltransferase 1Add BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO04928

PTM databases

iPTMnetiO04928

Expressioni

Gene expression databases

ExpressionAtlasiO04928 baseline and differential
GenevisibleiO04928 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G62430.1

Structurei

3D structure databases

ProteinModelPortaliO04928
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1440 Eukaryota
COG0575 LUCA
HOGENOMiHOG000209582
InParanoidiO04928
KOiK00981
OMAiHSQWLTC
OrthoDBiEOG093607DA
PhylomeDBiO04928

Family and domain databases

InterProiView protein in InterPro
IPR000374 PC_trans
IPR016720 PC_Trfase_euk
PIRSFiPIRSF018269 PC_trans_euk, 1 hit
PROSITEiView protein in PROSITE
PS01315 CDS, 1 hit

Sequencei

Sequence statusi: Complete.

O04928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEENVTSSP STPVHRLRHR RRSNEVVTDG DKVNASPLLV NDRNKYKSFM
60 70 80 90 100
VRTYSTLWMI GGFVLVVYMG HLYITAMVVV IQIFMAKELF NLLRKAPEDK
110 120 130 140 150
CLPYIKQLNW HFFFTAMLFV YGRILSQRLA NTMTADQFFY RLVSGLIKYH
160 170 180 190 200
MAICYLLYII GFMWFILTLK KKMYKYQFGQ YAWTHMILIV VFTQSSFTVA
210 220 230 240 250
NIFEGIFWFL LPASLIIIND IFAYIFGFFF GRTPLIKLSP KKTWEGFIGA
260 270 280 290 300
SVTTIISAFV LANILGRFPW LTCPRQDLST GWLQCDADPL FKPEPFALPA
310 320 330 340 350
WIPEWFPWKE MTILPVQWHA LCLGLFASII APFGGFFASG FKRAFKIKDF
360 370 380 390 400
GDSIPGHGGI TDRMDCQMVM AVFAYIYLQS FIVSQSVSVD KILDQILTNL
410 420
TFEEQQALFV KLGQMLKDKL S
Length:421
Mass (Da):48,660
Last modified:July 1, 1997 - v1
Checksum:i96D238DB4B913AA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94306 mRNA Translation: CAA63969.1
AC003113 Genomic DNA Translation: AAF70845.1
CP002684 Genomic DNA Translation: AEE33967.1
PIRiT01455
RefSeqiNP_176433.2, NM_104923.4
UniGeneiAt.23658

Genome annotation databases

EnsemblPlantsiAT1G62430.1; AT1G62430.1; AT1G62430
GeneIDi842541
GrameneiAT1G62430.1; AT1G62430.1; AT1G62430
KEGGiath:AT1G62430

Similar proteinsi

Entry informationi

Entry nameiCDS1_ARATH
AccessioniPrimary (citable) accession number: O04928
Secondary accession number(s): O48808
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health