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O04928

- CDS1_ARATH

UniProt

O04928 - CDS1_ARATH

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Protein

Phosphatidate cytidylyltransferase

Gene

CDS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction.

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: TAIR

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
  2. developmental vegetative growth Source: TAIR
  3. phospholipid biosynthetic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:AT1G62430-MONOMER.
ReactomeiREACT_187648. Synthesis of PG.
REACT_187680. Synthesis of PI.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:CDS1
Ordered Locus Names:At1g62430
ORF Names:F24O1.17, F24O1_45
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G62430.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence AnalysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence AnalysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence AnalysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: TAIR
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Phosphatidate cytidylyltransferasePRO_0000090723Add
BLAST

Proteomic databases

PaxDbiO04928.
PRIDEiO04928.

Expressioni

Gene expression databases

GenevestigatoriO04928.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G62430.1-P.

Structurei

3D structure databases

ProteinModelPortaliO04928.
SMRiO04928. Positions 193-379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000209582.
InParanoidiO04928.
KOiK00981.
OMAiYIYYQSF.
PhylomeDBiO04928.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O04928-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEENVTSSP STPVHRLRHR RRSNEVVTDG DKVNASPLLV NDRNKYKSFM
60 70 80 90 100
VRTYSTLWMI GGFVLVVYMG HLYITAMVVV IQIFMAKELF NLLRKAPEDK
110 120 130 140 150
CLPYIKQLNW HFFFTAMLFV YGRILSQRLA NTMTADQFFY RLVSGLIKYH
160 170 180 190 200
MAICYLLYII GFMWFILTLK KKMYKYQFGQ YAWTHMILIV VFTQSSFTVA
210 220 230 240 250
NIFEGIFWFL LPASLIIIND IFAYIFGFFF GRTPLIKLSP KKTWEGFIGA
260 270 280 290 300
SVTTIISAFV LANILGRFPW LTCPRQDLST GWLQCDADPL FKPEPFALPA
310 320 330 340 350
WIPEWFPWKE MTILPVQWHA LCLGLFASII APFGGFFASG FKRAFKIKDF
360 370 380 390 400
GDSIPGHGGI TDRMDCQMVM AVFAYIYLQS FIVSQSVSVD KILDQILTNL
410 420
TFEEQQALFV KLGQMLKDKL S
Length:421
Mass (Da):48,660
Last modified:July 1, 1997 - v1
Checksum:i96D238DB4B913AA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94306 mRNA. Translation: CAA63969.1.
AC003113 Genomic DNA. Translation: AAF70845.1.
CP002684 Genomic DNA. Translation: AEE33967.1.
PIRiT01455.
RefSeqiNP_176433.2. NM_104923.3.
UniGeneiAt.23658.

Genome annotation databases

EnsemblPlantsiAT1G62430.1; AT1G62430.1; AT1G62430.
GeneIDi842541.
KEGGiath:AT1G62430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94306 mRNA. Translation: CAA63969.1 .
AC003113 Genomic DNA. Translation: AAF70845.1 .
CP002684 Genomic DNA. Translation: AEE33967.1 .
PIRi T01455.
RefSeqi NP_176433.2. NM_104923.3.
UniGenei At.23658.

3D structure databases

ProteinModelPortali O04928.
SMRi O04928. Positions 193-379.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G62430.1-P.

Proteomic databases

PaxDbi O04928.
PRIDEi O04928.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G62430.1 ; AT1G62430.1 ; AT1G62430 .
GeneIDi 842541.
KEGGi ath:AT1G62430.

Organism-specific databases

TAIRi AT1G62430.

Phylogenomic databases

eggNOGi COG0575.
HOGENOMi HOG000209582.
InParanoidi O04928.
KOi K00981.
OMAi YIYYQSF.
PhylomeDBi O04928.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .
BioCyci MetaCyc:AT1G62430-MONOMER.
Reactomei REACT_187648. Synthesis of PG.
REACT_187680. Synthesis of PI.

Gene expression databases

Genevestigatori O04928.

Family and domain databases

InterProi IPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complementary DNAs encoding eukaryotic-type cytidine-5'-diphosphate-diacylglycerol synthases of two plant species."
    Kopka J., Ludewig M., Mueller-Roeber B.
    Plant Physiol. 113:997-1002(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. C24.
    Tissue: Flower and Silique.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCDS1_ARATH
AccessioniPrimary (citable) accession number: O04928
Secondary accession number(s): O48808
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 26, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3