O04928 (CDS1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidate cytidylyltransferase
EC=2.7.7.41

Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase

Gene names

Name:	CDS1
Ordered Locus Names:	At1g62430
ORF Names:	F24O1.17, F24O1_45

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction.
Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Traceable author statement Ref.1. Source: TAIR
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from direct assay Ref.1. Source: TAIR
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Phosphatidate cytidylyltransferase		PRO_0000090723
Regions
	Transmembrane	60 – 80	21	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	206 – 226	21	Helical; Potential
	Transmembrane	246 – 266	21	Helical; Potential
	Transmembrane	321 – 341	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O04928 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 96D238DB4B913AA3	FASTA	421	48,660
	10 20 30 40 50 60 MEEENVTSSP STPVHRLRHR RRSNEVVTDG DKVNASPLLV NDRNKYKSFM VRTYSTLWMI 70 80 90 100 110 120 GGFVLVVYMG HLYITAMVVV IQIFMAKELF NLLRKAPEDK CLPYIKQLNW HFFFTAMLFV 130 140 150 160 170 180 YGRILSQRLA NTMTADQFFY RLVSGLIKYH MAICYLLYII GFMWFILTLK KKMYKYQFGQ 190 200 210 220 230 240 YAWTHMILIV VFTQSSFTVA NIFEGIFWFL LPASLIIIND IFAYIFGFFF GRTPLIKLSP 250 260 270 280 290 300 KKTWEGFIGA SVTTIISAFV LANILGRFPW LTCPRQDLST GWLQCDADPL FKPEPFALPA 310 320 330 340 350 360 WIPEWFPWKE MTILPVQWHA LCLGLFASII APFGGFFASG FKRAFKIKDF GDSIPGHGGI 370 380 390 400 410 420 TDRMDCQMVM AVFAYIYLQS FIVSQSVSVD KILDQILTNL TFEEQQALFV KLGQMLKDKL S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complementary DNAs encoding eukaryotic-type cytidine-5'-diphosphate-diacylglycerol synthases of two plant species." Kopka J., Ludewig M., Mueller-Roeber B. Plant Physiol. 113:997-1002(1997) [PubMed: 9085581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. C24. Tissue: Flower and Silique.
[2]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X94306 mRNA. Translation: CAA63969.1. AC003113 Genomic DNA. Translation: AAF70845.1. CP002684 Genomic DNA. Translation: AEE33967.1.
IPI	IPI00532046.
PIR	T01455.
RefSeq	NP_176433.2. NM_104923.3.
UniGene	At.23658.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O04928.
Proteomic databases
PRIDE	O04928.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G62430.1; AT1G62430.1; AT1G62430.
GeneID	842541.
GenomeReviews	Gene locus AT1G62430 in contig CT485782_GR.
KEGG	ath:AT1G62430.
NMPDR	fig|3702.1.peg.5637.
Organism-specific databases
TAIR	At1g62430.
Phylogenomic databases
eggNOG	KOG1440.
GeneTree	EPGT00050000013035.
HOGENOM	HBG629124.
InParanoid	O04928.
OMA	VVYMGHL.
PhylomeDB	O04928.
ProtClustDB	PLN02594.
Gene expression databases
ArrayExpress	O04928.
Genevestigator	O04928.
GermOnline	AT1G62430. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR000374. PC_trans. IPR016720. PC_Trfase_euk. [Graphical view]
KO	K00981.
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PIRSF	PIRSF018269. PC_trans_euk. 1 hit.
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDS1_ARATH

Accession

Primary (citable) accession number: O04928
Secondary accession number(s): O48808

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 1, 1997
Last modified:	November 16, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program