Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O04922

- GPX2_ARATH

UniProt

O04922 - GPX2_ARATH

Protein

Probable glutathione peroxidase 2

Gene

GPX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May constitute a glutathione peroxidase-like protective system against oxidative stresses.By similarity

    Catalytic activityi

    2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei41 – 411By similarity

    GO - Molecular functioni

    1. glutathione peroxidase activity Source: UniProtKB-EC
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. response to oxidative stress Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Stress response

    Enzyme and pathway databases

    BioCyciARA:AT2G31570-MONOMER.

    Protein family/group databases

    PeroxiBasei2500. AtGPx02.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutathione peroxidase 2 (EC:1.11.1.9)
    Gene namesi
    Name:GPX2
    Ordered Locus Names:At2g31570
    ORF Names:T9H9.9
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G31570.

    Subcellular locationi

    Cytoplasmcytosol 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 169169Probable glutathione peroxidase 2PRO_0000066637Add
    BLAST

    Proteomic databases

    PaxDbiO04922.
    PRIDEiO04922.

    Expressioni

    Tissue specificityi

    Expressed in leaves, stems, flowers, green siliques and roots.1 Publication

    Inductioni

    By salt stress and metals. Up-regulated by salicylic acid (SA).1 Publication

    Gene expression databases

    ArrayExpressiO04922.
    GenevestigatoriO04922.

    Interactioni

    Subunit structurei

    Interacts with DJ1A.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BRL1Q9ZPS91EBI-2293817,EBI-2292728

    Protein-protein interaction databases

    BioGridi3062. 2 interactions.
    IntActiO04922. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO04922.
    SMRiO04922. Positions 7-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutathione peroxidase family.Curated

    Phylogenomic databases

    eggNOGiCOG0386.
    HOGENOMiHOG000277054.
    InParanoidiO04922.
    KOiK00432.
    OMAiMSAFHDI.
    PhylomeDBiO04922.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR000889. Glutathione_peroxidase.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR11592. PTHR11592. 1 hit.
    PfamiPF00255. GSHPx. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
    PRINTSiPR01011. GLUTPROXDASE.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
    PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
    PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O04922-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADESPKSIY DFTVKDIGGN DVSLDQYKGK TLLVVNVASK CGLTDANYKE    50
    LNVLYEKYKE QGLEILAFPC NQFLGQEPGN NEEIQQTVCT RFKAEFPIFD 100
    KVDVNGKNTA PLYKYLKAEK GGLLIDAIKW NFTKFLVSPD GKVLQRYSPR 150
    TSPLQFEKDI QTALGQASS 169
    Length:169
    Mass (Da):18,945
    Last modified:July 1, 1997 - v1
    Checksum:i23930B83A0AE3251
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U94495 mRNA. Translation: AAB52725.1.
    AC007071 Genomic DNA. Translation: AAD24836.1.
    CP002685 Genomic DNA. Translation: AEC08562.1.
    AY058187 mRNA. Translation: AAL25600.1.
    AY044330 mRNA. Translation: AAK73271.1.
    AY098982 mRNA. Translation: AAM19992.1.
    AY086518 mRNA. Translation: AAM63517.1.
    PIRiD84722.
    RefSeqiNP_180715.1. NM_128714.3.
    UniGeneiAt.10210.
    At.28566.

    Genome annotation databases

    EnsemblPlantsiAT2G31570.1; AT2G31570.1; AT2G31570.
    GeneIDi817715.
    KEGGiath:AT2G31570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U94495 mRNA. Translation: AAB52725.1 .
    AC007071 Genomic DNA. Translation: AAD24836.1 .
    CP002685 Genomic DNA. Translation: AEC08562.1 .
    AY058187 mRNA. Translation: AAL25600.1 .
    AY044330 mRNA. Translation: AAK73271.1 .
    AY098982 mRNA. Translation: AAM19992.1 .
    AY086518 mRNA. Translation: AAM63517.1 .
    PIRi D84722.
    RefSeqi NP_180715.1. NM_128714.3.
    UniGenei At.10210.
    At.28566.

    3D structure databases

    ProteinModelPortali O04922.
    SMRi O04922. Positions 7-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 3062. 2 interactions.
    IntActi O04922. 2 interactions.

    Protein family/group databases

    PeroxiBasei 2500. AtGPx02.

    Proteomic databases

    PaxDbi O04922.
    PRIDEi O04922.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G31570.1 ; AT2G31570.1 ; AT2G31570 .
    GeneIDi 817715.
    KEGGi ath:AT2G31570.

    Organism-specific databases

    GeneFarmi 2049. 163.
    TAIRi AT2G31570.

    Phylogenomic databases

    eggNOGi COG0386.
    HOGENOMi HOG000277054.
    InParanoidi O04922.
    KOi K00432.
    OMAi MSAFHDI.
    PhylomeDBi O04922.

    Enzyme and pathway databases

    BioCyci ARA:AT2G31570-MONOMER.

    Gene expression databases

    ArrayExpressi O04922.
    Genevestigatori O04922.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR000889. Glutathione_peroxidase.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR11592. PTHR11592. 1 hit.
    Pfami PF00255. GSHPx. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
    PRINTSi PR01011. GLUTPROXDASE.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS00460. GLUTATHIONE_PEROXID_1. 1 hit.
    PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
    PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Glutathione peroxidase cDNA from Arabidopsis."
      Turano F.J., Caldwell C.R., McMahon M.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Glutathione peroxidase genes in Arabidopsis are ubiquitous and regulated by abiotic stresses through diverse signaling pathways."
      Rodriguez Milla M.A., Maurer A., Rodriguez Huete A., Gustafson J.P.
      Plant J. 36:602-615(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION.
    7. "The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation."
      Xu X.M., Lin H., Maple J., Bjoerkblom B., Alves G., Larsen J.P., Moeller S.G.
      J. Cell Sci. 123:1644-1651(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH DJ1A.

    Entry informationi

    Entry nameiGPX2_ARATH
    AccessioniPrimary (citable) accession number: O04922
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3