Reviewed, UniProtKB/Swiss-Prot O04922 (GPX2_ARATH)

Names and origin

Protein names

Recommended name:
    Probable glutathione peroxidase 2
    EC=1.11.1.9

Gene names

Name:	GPX2
Ordered Locus Names:	At2g31570
ORF Names:	T9H9.9

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May constitute a glutathionine peroxidase-like protective system against oxidative stresses.
Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Tissue specificity	Expressed in leaves, stems, flowers, green siliques and roots. Ref.5
Induction	By salt stress and metals. Up-regulated by salicylic acid (SA). Ref.5
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Biological process	Stress response
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Ref.5 Non-traceable author statement. Source: TAIR
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BRL1	Q9ZPS9	1	EBI-2293817,EBI-2292728

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 169	169	Probable glutathione peroxidase 2		PRO_0000066637
Sites
	Active site	41	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O04922-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 23930B83A0AE3251	FASTA	169	18,945
	10 20 30 40 50 60 MADESPKSIY DFTVKDIGGN DVSLDQYKGK TLLVVNVASK CGLTDANYKE LNVLYEKYKE 70 80 90 100 110 120 QGLEILAFPC NQFLGQEPGN NEEIQQTVCT RFKAEFPIFD KVDVNGKNTA PLYKYLKAEK 130 140 150 160 GGLLIDAIKW NFTKFLVSPD GKVLQRYSPR TSPLQFEKDI QTALGQASS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Glutathione peroxidase cDNA from Arabidopsis." Turano F.J., Caldwell C.R., McMahon M. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia.
[2]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Glutathione peroxidase genes in Arabidopsis are ubiquitous and regulated by abiotic stresses through diverse signaling pathways." Rodriguez Milla M.A., Maurer A., Rodriguez Huete A., Gustafson J.P. Plant J. 36:602-615(2003) [PubMed: 14617062] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U94495 mRNA. Translation: AAB52725.1. AC007071 Genomic DNA. Translation: AAD24836.1. AY058187 mRNA. Translation: AAL25600.1. AY044330 mRNA. Translation: AAK73271.1. AY098982 mRNA. Translation: AAM19992.1. AY086518 mRNA. Translation: AAM63517.1.
IPI	IPI00517494.
PIR	D84722.
RefSeq	NP_180715.1.
UniGene	At.10210
3D structure databases
HSSP	HSSP built from PDB template 1GP1 based on UniProtKB P00435.
ModBase	Search...
Protein family/group databases
PeroxiBase	2500. AtGPx02.
Proteomic databases
PRIDE	O04922.
Genome annotation databases
GeneID	817715.
GenomeReviews	Gene locus AT2G31570 in contig CT485783_GR.
KEGG	ath:AT2G31570.
NMPDR	fig|3702.1.peg.10216.
Organism-specific databases
GeneFarm	2049. 163.
TAIR	At2g31570.
Phylogenomic databases
OMA	O04922. ESPKSIY.
Enzyme and pathway databases
BRENDA	1.11.1.9. 302.
Gene expression databases
ArrayExpress	O04922.
GermOnline	AT2G31570. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX2_ARATH

Accession

Primary (citable) accession number: O04922

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	July 1, 1997
Last modified:	June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)