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O04922

- GPX2_ARATH

UniProt

O04922 - GPX2_ARATH

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Protein

Probable glutathione peroxidase 2

Gene

GPX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May constitute a glutathione peroxidase-like protective system against oxidative stresses.By similarity

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411By similarity

GO - Molecular functioni

  1. glutathione peroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciARA:AT2G31570-MONOMER.
ReactomeiREACT_233508. Synthesis of 5-eicosatetraenoic acids.
REACT_240829. Synthesis of 12-eicosatetraenoic acid derivatives.

Protein family/group databases

PeroxiBasei2500. AtGPx02.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione peroxidase 2 (EC:1.11.1.9)
Gene namesi
Name:GPX2
Ordered Locus Names:At2g31570
ORF Names:T9H9.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G31570.

Subcellular locationi

Cytoplasmcytosol 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169Probable glutathione peroxidase 2PRO_0000066637Add
BLAST

Proteomic databases

PaxDbiO04922.
PRIDEiO04922.

Expressioni

Tissue specificityi

Expressed in leaves, stems, flowers, green siliques and roots.1 Publication

Inductioni

By salt stress and metals. Up-regulated by salicylic acid (SA).1 Publication

Gene expression databases

ExpressionAtlasiO04922. baseline and differential.
GenevestigatoriO04922.

Interactioni

Subunit structurei

Interacts with DJ1A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BRL1Q9ZPS91EBI-2293817,EBI-2292728

Protein-protein interaction databases

BioGridi3062. 2 interactions.
IntActiO04922. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO04922.
SMRiO04922. Positions 7-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiCOG0386.
HOGENOMiHOG000277054.
InParanoidiO04922.
KOiK00432.
OMAiMSAFHDI.
PhylomeDBiO04922.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O04922-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADESPKSIY DFTVKDIGGN DVSLDQYKGK TLLVVNVASK CGLTDANYKE
60 70 80 90 100
LNVLYEKYKE QGLEILAFPC NQFLGQEPGN NEEIQQTVCT RFKAEFPIFD
110 120 130 140 150
KVDVNGKNTA PLYKYLKAEK GGLLIDAIKW NFTKFLVSPD GKVLQRYSPR
160
TSPLQFEKDI QTALGQASS
Length:169
Mass (Da):18,945
Last modified:July 1, 1997 - v1
Checksum:i23930B83A0AE3251
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94495 mRNA. Translation: AAB52725.1.
AC007071 Genomic DNA. Translation: AAD24836.1.
CP002685 Genomic DNA. Translation: AEC08562.1.
AY058187 mRNA. Translation: AAL25600.1.
AY044330 mRNA. Translation: AAK73271.1.
AY098982 mRNA. Translation: AAM19992.1.
AY086518 mRNA. Translation: AAM63517.1.
PIRiD84722.
RefSeqiNP_180715.1. NM_128714.3.
UniGeneiAt.10210.
At.28566.

Genome annotation databases

EnsemblPlantsiAT2G31570.1; AT2G31570.1; AT2G31570.
GeneIDi817715.
KEGGiath:AT2G31570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94495 mRNA. Translation: AAB52725.1 .
AC007071 Genomic DNA. Translation: AAD24836.1 .
CP002685 Genomic DNA. Translation: AEC08562.1 .
AY058187 mRNA. Translation: AAL25600.1 .
AY044330 mRNA. Translation: AAK73271.1 .
AY098982 mRNA. Translation: AAM19992.1 .
AY086518 mRNA. Translation: AAM63517.1 .
PIRi D84722.
RefSeqi NP_180715.1. NM_128714.3.
UniGenei At.10210.
At.28566.

3D structure databases

ProteinModelPortali O04922.
SMRi O04922. Positions 7-164.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 3062. 2 interactions.
IntActi O04922. 2 interactions.

Protein family/group databases

PeroxiBasei 2500. AtGPx02.

Proteomic databases

PaxDbi O04922.
PRIDEi O04922.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G31570.1 ; AT2G31570.1 ; AT2G31570 .
GeneIDi 817715.
KEGGi ath:AT2G31570.

Organism-specific databases

GeneFarmi 2049. 163.
TAIRi AT2G31570.

Phylogenomic databases

eggNOGi COG0386.
HOGENOMi HOG000277054.
InParanoidi O04922.
KOi K00432.
OMAi MSAFHDI.
PhylomeDBi O04922.

Enzyme and pathway databases

BioCyci ARA:AT2G31570-MONOMER.
Reactomei REACT_233508. Synthesis of 5-eicosatetraenoic acids.
REACT_240829. Synthesis of 12-eicosatetraenoic acid derivatives.

Gene expression databases

ExpressionAtlasi O04922. baseline and differential.
Genevestigatori O04922.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11592. PTHR11592. 1 hit.
Pfami PF00255. GSHPx. 1 hit.
[Graphical view ]
PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
PRINTSi PR01011. GLUTPROXDASE.
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Glutathione peroxidase cDNA from Arabidopsis."
    Turano F.J., Caldwell C.R., McMahon M.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Glutathione peroxidase genes in Arabidopsis are ubiquitous and regulated by abiotic stresses through diverse signaling pathways."
    Rodriguez Milla M.A., Maurer A., Rodriguez Huete A., Gustafson J.P.
    Plant J. 36:602-615(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION.
  7. "The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation."
    Xu X.M., Lin H., Maple J., Bjoerkblom B., Alves G., Larsen J.P., Moeller S.G.
    J. Cell Sci. 123:1644-1651(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH DJ1A.

Entry informationi

Entry nameiGPX2_ARATH
AccessioniPrimary (citable) accession number: O04922
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 1, 1997
Last modified: November 26, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3