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O04922 (GPX2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glutathione peroxidase 2

EC=1.11.1.9
Gene names
Name:GPX2
Ordered Locus Names:At2g31570
ORF Names:T9H9.9
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May constitute a glutathione peroxidase-like protective system against oxidative stresses By similarity.

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Subunit structure

Interacts with DJ1A. Ref.7

Subcellular location

Cytoplasmcytosol. Nucleus Ref.7.

Tissue specificity

Expressed in leaves, stems, flowers, green siliques and roots. Ref.6

Induction

By salt stress and metals. Up-regulated by salicylic acid (SA). Ref.6

Sequence similarities

Belongs to the glutathione peroxidase family.

Ontologies

Keywords
   Biological processStress response
   Cellular componentCytoplasm
Nucleus
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to oxidative stress

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytosol

Inferred from direct assay Ref.7. Source: UniProtKB

nucleus

Inferred from direct assay Ref.7. Source: UniProtKB

plasma membrane

Inferred from direct assay PubMed 22923678. Source: TAIR

   Molecular_functionglutathione peroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BRL1Q9ZPS91EBI-2293817,EBI-2292728

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 169169Probable glutathione peroxidase 2
PRO_0000066637

Sites

Active site411 By similarity

Sequences

Sequence LengthMass (Da)Tools
O04922 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 23930B83A0AE3251

FASTA16918,945
        10         20         30         40         50         60 
MADESPKSIY DFTVKDIGGN DVSLDQYKGK TLLVVNVASK CGLTDANYKE LNVLYEKYKE 

        70         80         90        100        110        120 
QGLEILAFPC NQFLGQEPGN NEEIQQTVCT RFKAEFPIFD KVDVNGKNTA PLYKYLKAEK 

       130        140        150        160 
GGLLIDAIKW NFTKFLVSPD GKVLQRYSPR TSPLQFEKDI QTALGQASS 

« Hide

References

« Hide 'large scale' references
[1]"Glutathione peroxidase cDNA from Arabidopsis."
Turano F.J., Caldwell C.R., McMahon M.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Columbia.
[2]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"Full-length cDNA from Arabidopsis thaliana."
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Glutathione peroxidase genes in Arabidopsis are ubiquitous and regulated by abiotic stresses through diverse signaling pathways."
Rodriguez Milla M.A., Maurer A., Rodriguez Huete A., Gustafson J.P.
Plant J. 36:602-615(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION.
[7]"The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation."
Xu X.M., Lin H., Maple J., Bjoerkblom B., Alves G., Larsen J.P., Moeller S.G.
J. Cell Sci. 123:1644-1651(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH DJ1A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U94495 mRNA. Translation: AAB52725.1.
AC007071 Genomic DNA. Translation: AAD24836.1.
CP002685 Genomic DNA. Translation: AEC08562.1.
AY058187 mRNA. Translation: AAL25600.1.
AY044330 mRNA. Translation: AAK73271.1.
AY098982 mRNA. Translation: AAM19992.1.
AY086518 mRNA. Translation: AAM63517.1.
PIRD84722.
RefSeqNP_180715.1. NM_128714.3.
UniGeneAt.10210.
At.28566.

3D structure databases

ProteinModelPortalO04922.
SMRO04922. Positions 7-164.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid3062. 2 interactions.
IntActO04922. 2 interactions.

Protein family/group databases

PeroxiBase2500. AtGPx02.

Proteomic databases

PaxDbO04922.
PRIDEO04922.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G31570.1; AT2G31570.1; AT2G31570.
GeneID817715.
KEGGath:AT2G31570.

Organism-specific databases

GeneFarm2049. 163.
TAIRAT2G31570.

Phylogenomic databases

eggNOGCOG0386.
HOGENOMHOG000277054.
InParanoidO04922.
KOK00432.
OMAEIAEFCE.
PhylomeDBO04922.
ProtClustDBPLN02412.

Enzyme and pathway databases

BioCycARA:AT2G31570-MONOMER.

Gene expression databases

ArrayExpressO04922.
GenevestigatorO04922.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11592. PTHR11592. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPX2_ARATH
AccessionPrimary (citable) accession number: O04922
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 1, 1997
Last modified: February 19, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names