Reviewed, UniProtKB/Swiss-Prot O04895 (BADH_AMAHP)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase, chloroplastic
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:

BADH4

Organism

Amaranthus hypochondriacus (Prince-of-Wales feather)

Taxonomic identifier

28502 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › Caryophyllales › Amaranthaceae › Amaranthus

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	Plastid › chloroplast.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 7	7	Chloroplast Potential
	Chain	8 – 501	494	Betaine aldehyde dehydrogenase, chloroplastic		PRO_0000007178
Regions
	Nucleotide binding	238 – 243	6	NAD By similarity
Sites
	Active site	260	1	Proton acceptor By similarity
	Active site	294	1	Nucleophile By similarity
	Site	162	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	O04895-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: D5065A91BFC0D37E	FASTA	501	54,504
	10 20 30 40 50 60 MAIRVPSRQL FIDGEWREPI KKNRIPIINP STEEIIGDIP AATAEDVELA VAAARRALKR 70 80 90 100 110 120 NKGEDWASAS GAHRAKYLRA IAAKITEKKD YFAKLEAMDC GKPLDEAARD IDDVAGCFEY 130 140 150 160 170 180 YADQAEALDA KQKAPIALPM DTFKCHVLKQ PIGVVGLISP WNYPLLMATW KVAPALAAGC 190 200 210 220 230 240 SAVLKPSELA SVTCLELAEV CREVGLPPGV LNILTGLGPE AGGPLACHPD VDKVAFTGST 250 260 270 280 290 300 ATGSKVMSSA AQLVKPVTLE LGGKSPIVIF EDVDLDKAAE WTAFGCFWTN GQICSATSRL 310 320 330 340 350 360 LVHESIAAEF LDRLVKWCKN IKISDPFEEG CRLGPVVSKS QYEKVLKFIS TAKSEGATIL 370 380 390 400 410 420 CGGSRPEHLK KGYYVEPTII SDVSTSMQIW REEVFGPVLC QKTFGSEDEA IELANDTQYG 430 440 450 460 470 480 LGAAVLSKDL DRCERITKAL EVGAVWVNCS QPCFTQAPWG GTKRSGFGRE LGEWGIENYL 490 500 NIKQVTRDTS TDEPWGWYKS P

References

[1]

"Molecular characterization of two genes encoding betaine aldehyde dehydrogenase from amaranth. Expression in leaves under short-term exposure to osmotic stress or abscisic acid." Legaria J., Rajsbaum R., Munoz-Clares R.A., Villegas-Sepulveda N., Simpson J., Iturriaga G. Gene 218:69-76(1998) [PubMed: 9751804] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Leaf.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF000132 Genomic DNA. Translation: AAB58165.1.
3D structure databases
HSSP	HSSP built from PDB template 1O04 based on UniProtKB P05091.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.2.1.8. 2722.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BADH_AMAHP

Accession

Primary (citable) accession number: O04895

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 1, 1997
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)