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O04860

- PP2A5_TOBAC

UniProt

O04860 - PP2A5_TOBAC

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Protein

Serine/threonine-protein phosphatase PP2A-5 catalytic subunit

Gene
NPP5
Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Manganese 1 By similarity
Metal bindingi64 – 641Manganese 1 By similarity
Metal bindingi90 – 901Manganese 1 By similarity
Metal bindingi90 – 901Manganese 2 By similarity
Metal bindingi122 – 1221Manganese 2 By similarity
Active sitei123 – 1231Proton donor By similarity
Metal bindingi172 – 1721Manganese 2 By similarity
Metal bindingi246 – 2461Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-5 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:NPP5
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Serine/threonine-protein phosphatase PP2A-5 catalytic subunitPRO_0000058866Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO04860.
SMRiO04860. Positions 15-314.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O04860-1 [UniParc]FASTAAdd to Basket

« Hide

MSSSDLVAAS IQGNLDEQIS QLMQCKPLSE PDVRALCEKA KEILAEESNV    50
QPVKSPVTIC GDIHGQFHDL AELFRIGGQC PDTNYLFMGD YVDRGYYSVE 100
TVTLLVALKV RYPQRLTILR GNHESRQITQ VYGFYDECLR KYGNANVWKT 150
FTDLFDYFPL TALVESEIFC LHGGLSPSIE TLDNVRSFDR VQEVPHEGAM 200
CDLLWSDPDD CCGWGMSPRG AGYTFGQDIS EQFHQTNNLK LIARAHQLVM 250
EGYNWSHEQK VVTIFSAPNY CYRCGNMASI LEVDDCRGHT FIQFDPAPRR 300
GEPDVTRRTP DYFL 314
Length:314
Mass (Da):35,640
Last modified:July 1, 1997 - v1
Checksum:i77F8348771E078C3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z93772 mRNA. Translation: CAB07807.1.
PIRiT03600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z93772 mRNA. Translation: CAB07807.1 .
PIRi T03600.

3D structure databases

ProteinModelPortali O04860.
SMRi O04860. Positions 15-314.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Multiple genes encoding serine/threonine protein phosphatases and their differential expression in Nicotiana tabacum."
    Suh M., Cho H., Kim Y., Liu J., Lee H.
    Plant Mol. Biol. 36:315-322(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Xanthi.

Entry informationi

Entry nameiPP2A5_TOBAC
AccessioniPrimary (citable) accession number: O04860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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