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O04860 (PP2A5_TOBAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP2A-5 catalytic subunit

EC=3.1.3.16
Gene names
Name:NPP5
OrganismNicotiana tabacum (Common tobacco)
Taxonomic identifier4097 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandIron
Manganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Serine/threonine-protein phosphatase PP2A-5 catalytic subunit
PRO_0000058866

Sites

Active site1231Proton donor By similarity
Metal binding621Iron By similarity
Metal binding641Iron By similarity
Metal binding901Iron By similarity
Metal binding901Manganese By similarity
Metal binding1221Manganese By similarity
Metal binding1721Manganese By similarity
Metal binding2461Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
O04860 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 77F8348771E078C3

FASTA31435,640
        10         20         30         40         50         60 
MSSSDLVAAS IQGNLDEQIS QLMQCKPLSE PDVRALCEKA KEILAEESNV QPVKSPVTIC 

        70         80         90        100        110        120 
GDIHGQFHDL AELFRIGGQC PDTNYLFMGD YVDRGYYSVE TVTLLVALKV RYPQRLTILR 

       130        140        150        160        170        180 
GNHESRQITQ VYGFYDECLR KYGNANVWKT FTDLFDYFPL TALVESEIFC LHGGLSPSIE 

       190        200        210        220        230        240 
TLDNVRSFDR VQEVPHEGAM CDLLWSDPDD CCGWGMSPRG AGYTFGQDIS EQFHQTNNLK 

       250        260        270        280        290        300 
LIARAHQLVM EGYNWSHEQK VVTIFSAPNY CYRCGNMASI LEVDDCRGHT FIQFDPAPRR 

       310 
GEPDVTRRTP DYFL 

« Hide

References

[1]"Multiple genes encoding serine/threonine protein phosphatases and their differential expression in Nicotiana tabacum."
Suh M., Cho H., Kim Y., Liu J., Lee H.
Plant Mol. Biol. 36:315-322(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Xanthi.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z93772 mRNA. Translation: CAB07807.1.
PIRT03600.

3D structure databases

ProteinModelPortalO04860.
SMRO04860. Positions 15-314.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP2A5_TOBAC
AccessionPrimary (citable) accession number: O04860
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families