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O04860

- PP2A5_TOBAC

UniProt

O04860 - PP2A5_TOBAC

Protein

Serine/threonine-protein phosphatase PP2A-5 catalytic subunit

Gene

NPP5

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi62 – 621Manganese 1By similarity
    Metal bindingi64 – 641Manganese 1By similarity
    Metal bindingi90 – 901Manganese 1By similarity
    Metal bindingi90 – 901Manganese 2By similarity
    Metal bindingi122 – 1221Manganese 2By similarity
    Active sitei123 – 1231Proton donorBy similarity
    Metal bindingi172 – 1721Manganese 2By similarity
    Metal bindingi246 – 2461Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP2A-5 catalytic subunit (EC:3.1.3.16)
    Gene namesi
    Name:NPP5
    OrganismiNicotiana tabacum (Common tobacco)
    Taxonomic identifieri4097 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Serine/threonine-protein phosphatase PP2A-5 catalytic subunitPRO_0000058866Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO04860.
    SMRiO04860. Positions 15-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O04860-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSDLVAAS IQGNLDEQIS QLMQCKPLSE PDVRALCEKA KEILAEESNV    50
    QPVKSPVTIC GDIHGQFHDL AELFRIGGQC PDTNYLFMGD YVDRGYYSVE 100
    TVTLLVALKV RYPQRLTILR GNHESRQITQ VYGFYDECLR KYGNANVWKT 150
    FTDLFDYFPL TALVESEIFC LHGGLSPSIE TLDNVRSFDR VQEVPHEGAM 200
    CDLLWSDPDD CCGWGMSPRG AGYTFGQDIS EQFHQTNNLK LIARAHQLVM 250
    EGYNWSHEQK VVTIFSAPNY CYRCGNMASI LEVDDCRGHT FIQFDPAPRR 300
    GEPDVTRRTP DYFL 314
    Length:314
    Mass (Da):35,640
    Last modified:July 1, 1997 - v1
    Checksum:i77F8348771E078C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93772 mRNA. Translation: CAB07807.1.
    PIRiT03600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93772 mRNA. Translation: CAB07807.1 .
    PIRi T03600.

    3D structure databases

    ProteinModelPortali O04860.
    SMRi O04860. Positions 15-314.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple genes encoding serine/threonine protein phosphatases and their differential expression in Nicotiana tabacum."
      Suh M., Cho H., Kim Y., Liu J., Lee H.
      Plant Mol. Biol. 36:315-322(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Xanthi.

    Entry informationi

    Entry nameiPP2A5_TOBAC
    AccessioniPrimary (citable) accession number: O04860
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3