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Protein

Serine/threonine-protein phosphatase PP1 isozyme 3

Gene

NPP3

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61Manganese 1By similarity1
Metal bindingi63Manganese 1By similarity1
Metal bindingi89Manganese 1By similarity1
Metal bindingi89Manganese 2By similarity1
Metal bindingi121Manganese 2By similarity1
Active sitei122Proton donorBy similarity1
Metal bindingi170Manganese 2By similarity1
Metal bindingi245Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1 isozyme 3 (EC:3.1.3.16)
Gene namesi
Name:NPP3
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
Proteomesi
  • UP000084051 Componenti: Genome assembly

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588131 – 304Serine/threonine-protein phosphatase PP1 isozyme 3Add BLAST304

Proteomic databases

PRIDEiO04858.

Structurei

3D structure databases

ProteinModelPortaliO04858.
SMRiO04858.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

KOiK06269.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

O04858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTAAVDRII EKLIEVRSSN PGKLVQLSES EIKQLCVASR DIFLKQPNLL
60 70 80 90 100
ESEAPIKTRG DIHGQYSDLL RLFEYGGFPP EANYLFLGDY VDRGRQSLET
110 120 130 140 150
ICLLLAYKIK YPENFFLLRG NHECASINRI YGFYDECKRR FNVKLWKSFT
160 170 180 190 200
DCFNCLPVAA LIDEKILCMH GGLSPDLSSL DQIRNLPRPT AIPDTGLLCD
210 220 230 240 250
LQRSDPGKDV KGWGMNDRGV SYTFGPDKVS EFLSKHDLDL VCRAHQVVED
260 270 280 290 300
GYEFFAESEL VTIFSAPNYC GEFDNAGAMM SVDENLLCSF QILKPAEKKN

KFVM
Length:304
Mass (Da):34,441
Last modified:July 1, 1997 - v1
Checksum:iD8A3D5D94857A452
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93770 mRNA. Translation: CAB07805.1.
PIRiT03597.
RefSeqiNP_001312637.1. NM_001325708.1.
UniGeneiNta.8597.

Genome annotation databases

GeneIDi107801901.
KEGGinta:107801901.

Similar proteinsi

Entry informationi

Entry nameiPP13_TOBAC
AccessioniPrimary (citable) accession number: O04858
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: October 25, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families