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O04858

- PP13_TOBAC

UniProt

O04858 - PP13_TOBAC

Protein

Serine/threonine-protein phosphatase PP1 isozyme 3

Gene

NPP3

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611Manganese 1By similarity
    Metal bindingi63 – 631Manganese 1By similarity
    Metal bindingi89 – 891Manganese 1By similarity
    Metal bindingi89 – 891Manganese 2By similarity
    Metal bindingi121 – 1211Manganese 2By similarity
    Active sitei122 – 1221Proton donorBy similarity
    Metal bindingi170 – 1701Manganese 2By similarity
    Metal bindingi245 – 2451Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP1 isozyme 3 (EC:3.1.3.16)
    Gene namesi
    Name:NPP3
    OrganismiNicotiana tabacum (Common tobacco)
    Taxonomic identifieri4097 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304Serine/threonine-protein phosphatase PP1 isozyme 3PRO_0000058813Add
    BLAST

    Proteomic databases

    PRIDEiO04858.

    Structurei

    3D structure databases

    ProteinModelPortaliO04858.
    SMRiO04858. Positions 6-302.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O04858-1 [UniParc]FASTAAdd to Basket

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    MDTAAVDRII EKLIEVRSSN PGKLVQLSES EIKQLCVASR DIFLKQPNLL    50
    ESEAPIKTRG DIHGQYSDLL RLFEYGGFPP EANYLFLGDY VDRGRQSLET 100
    ICLLLAYKIK YPENFFLLRG NHECASINRI YGFYDECKRR FNVKLWKSFT 150
    DCFNCLPVAA LIDEKILCMH GGLSPDLSSL DQIRNLPRPT AIPDTGLLCD 200
    LQRSDPGKDV KGWGMNDRGV SYTFGPDKVS EFLSKHDLDL VCRAHQVVED 250
    GYEFFAESEL VTIFSAPNYC GEFDNAGAMM SVDENLLCSF QILKPAEKKN 300
    KFVM 304
    Length:304
    Mass (Da):34,441
    Last modified:July 1, 1997 - v1
    Checksum:iD8A3D5D94857A452
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93770 mRNA. Translation: CAB07805.1.
    PIRiT03597.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93770 mRNA. Translation: CAB07805.1 .
    PIRi T03597.

    3D structure databases

    ProteinModelPortali O04858.
    SMRi O04858. Positions 6-302.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O04858.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple genes encoding serine/threonine protein phosphatases and their differential expression in Nicotiana tabacum."
      Suh M., Cho H., Kim Y., Liu J., Lee H.
      Plant Mol. Biol. 36:315-322(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Xanthi.

    Entry informationi

    Entry nameiPP13_TOBAC
    AccessioniPrimary (citable) accession number: O04858
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3