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Protein

Serine/threonine-protein phosphatase PP1 isozyme 2

Gene

NPP2

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Manganese 1By similarity1
Metal bindingi70Manganese 1By similarity1
Metal bindingi96Manganese 1By similarity1
Metal bindingi96Manganese 2By similarity1
Metal bindingi128Manganese 2By similarity1
Active sitei129Proton donorBy similarity1
Metal bindingi177Manganese 2By similarity1
Metal bindingi252Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1 isozyme 2 (EC:3.1.3.16)
Gene namesi
Name:NPP2
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588121 – 310Serine/threonine-protein phosphatase PP1 isozyme 2Add BLAST310

Proteomic databases

PRIDEiO04857.

Structurei

3D structure databases

ProteinModelPortaliO04857.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O04857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQNGQGIEP AVLDDIINRL LEFRNARTVR QVQLSEAEIR SLCTASKEIF
60 70 80 90 100
LHQPNLLELE APIKICGDIH GQYGDLLRLF EYGGFPPEAN YLFLGDYVDR
110 120 130 140 150
GKQSLETICL LLAYKIKYPE NFFLLRGNHE CASINRIYGF YDECKRRFNV
160 170 180 190 200
RLWKTNTDCF NCLPVAALID DKILCMHGGL SPDLTDLDEI RNLPRPTDIP
210 220 230 240 250
DSGLLCDLLW SDPSREVKGW GMNDRGVSYT FGSDKVAEFL MQHDMDLVCR
260 270 280 290 300
AHQVVEDGYE FFAERQLVTI FSAPNYCGEF DNAGAMMSVD ENLMCSFQIL
310
KPTDRKPRFL
Length:310
Mass (Da):35,435
Last modified:July 1, 1997 - v1
Checksum:i4EFA9FB525B7D4C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93769 mRNA. Translation: CAB07804.1.
PIRiT03596.
RefSeqiNP_001313158.1. NM_001326229.1.
UniGeneiNta.4231.

Genome annotation databases

GeneIDi107829724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93769 mRNA. Translation: CAB07804.1.
PIRiT03596.
RefSeqiNP_001313158.1. NM_001326229.1.
UniGeneiNta.4231.

3D structure databases

ProteinModelPortaliO04857.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO04857.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107829724.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP12_TOBAC
AccessioniPrimary (citable) accession number: O04857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.