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O04857

- PP12_TOBAC

UniProt

O04857 - PP12_TOBAC

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Protein

Serine/threonine-protein phosphatase PP1 isozyme 2

Gene

NPP2

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Manganese 1By similarity
Metal bindingi70 – 701Manganese 1By similarity
Metal bindingi96 – 961Manganese 1By similarity
Metal bindingi96 – 961Manganese 2By similarity
Metal bindingi128 – 1281Manganese 2By similarity
Active sitei129 – 1291Proton donorBy similarity
Metal bindingi177 – 1771Manganese 2By similarity
Metal bindingi252 – 2521Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1 isozyme 2 (EC:3.1.3.16)
Gene namesi
Name:NPP2
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Serine/threonine-protein phosphatase PP1 isozyme 2PRO_0000058812Add
BLAST

Proteomic databases

PRIDEiO04857.

Structurei

3D structure databases

ProteinModelPortaliO04857.
SMRiO04857. Positions 13-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O04857-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQNGQGIEP AVLDDIINRL LEFRNARTVR QVQLSEAEIR SLCTASKEIF
60 70 80 90 100
LHQPNLLELE APIKICGDIH GQYGDLLRLF EYGGFPPEAN YLFLGDYVDR
110 120 130 140 150
GKQSLETICL LLAYKIKYPE NFFLLRGNHE CASINRIYGF YDECKRRFNV
160 170 180 190 200
RLWKTNTDCF NCLPVAALID DKILCMHGGL SPDLTDLDEI RNLPRPTDIP
210 220 230 240 250
DSGLLCDLLW SDPSREVKGW GMNDRGVSYT FGSDKVAEFL MQHDMDLVCR
260 270 280 290 300
AHQVVEDGYE FFAERQLVTI FSAPNYCGEF DNAGAMMSVD ENLMCSFQIL
310
KPTDRKPRFL
Length:310
Mass (Da):35,435
Last modified:July 1, 1997 - v1
Checksum:i4EFA9FB525B7D4C3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z93769 mRNA. Translation: CAB07804.1.
PIRiT03596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z93769 mRNA. Translation: CAB07804.1 .
PIRi T03596.

3D structure databases

ProteinModelPortali O04857.
SMRi O04857. Positions 13-309.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O04857.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Multiple genes encoding serine/threonine protein phosphatases and their differential expression in Nicotiana tabacum."
    Suh M., Cho H., Kim Y., Liu J., Lee H.
    Plant Mol. Biol. 36:315-322(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Xanthi.

Entry informationi

Entry nameiPP12_TOBAC
AccessioniPrimary (citable) accession number: O04857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: October 1, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3