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Protein

Serine/threonine-protein phosphatase PP1 isozyme 2

Gene

NPP2

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Manganese 1By similarity1
Metal bindingi70Manganese 1By similarity1
Metal bindingi96Manganese 1By similarity1
Metal bindingi96Manganese 2By similarity1
Metal bindingi128Manganese 2By similarity1
Active sitei129Proton donorBy similarity1
Metal bindingi177Manganese 2By similarity1
Metal bindingi252Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1 isozyme 2 (EC:3.1.3.16)
Gene namesi
Name:NPP2
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
Proteomesi
  • UP000084051 Componenti: Genome assembly

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588121 – 310Serine/threonine-protein phosphatase PP1 isozyme 2Add BLAST310

Proteomic databases

PRIDEiO04857

Structurei

3D structure databases

ProteinModelPortaliO04857
SMRiO04857
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

KOiK06269

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR031675 STPPase_N
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF16891 STPPase_N, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

O04857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQNGQGIEP AVLDDIINRL LEFRNARTVR QVQLSEAEIR SLCTASKEIF
60 70 80 90 100
LHQPNLLELE APIKICGDIH GQYGDLLRLF EYGGFPPEAN YLFLGDYVDR
110 120 130 140 150
GKQSLETICL LLAYKIKYPE NFFLLRGNHE CASINRIYGF YDECKRRFNV
160 170 180 190 200
RLWKTNTDCF NCLPVAALID DKILCMHGGL SPDLTDLDEI RNLPRPTDIP
210 220 230 240 250
DSGLLCDLLW SDPSREVKGW GMNDRGVSYT FGSDKVAEFL MQHDMDLVCR
260 270 280 290 300
AHQVVEDGYE FFAERQLVTI FSAPNYCGEF DNAGAMMSVD ENLMCSFQIL
310
KPTDRKPRFL
Length:310
Mass (Da):35,435
Last modified:July 1, 1997 - v1
Checksum:i4EFA9FB525B7D4C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93769 mRNA Translation: CAB07804.1
PIRiT03596
RefSeqiNP_001313158.1, NM_001326229.1
UniGeneiNta.4231

Genome annotation databases

GeneIDi107829724
KEGGinta:107829724

Similar proteinsi

Entry informationi

Entry nameiPP12_TOBAC
AccessioniPrimary (citable) accession number: O04857
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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