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O04857

- PP12_TOBAC

UniProt

O04857 - PP12_TOBAC

Protein

Serine/threonine-protein phosphatase PP1 isozyme 2

Gene

NPP2

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi68 – 681Manganese 1By similarity
    Metal bindingi70 – 701Manganese 1By similarity
    Metal bindingi96 – 961Manganese 1By similarity
    Metal bindingi96 – 961Manganese 2By similarity
    Metal bindingi128 – 1281Manganese 2By similarity
    Active sitei129 – 1291Proton donorBy similarity
    Metal bindingi177 – 1771Manganese 2By similarity
    Metal bindingi252 – 2521Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP1 isozyme 2 (EC:3.1.3.16)
    Gene namesi
    Name:NPP2
    OrganismiNicotiana tabacum (Common tobacco)
    Taxonomic identifieri4097 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Serine/threonine-protein phosphatase PP1 isozyme 2PRO_0000058812Add
    BLAST

    Proteomic databases

    PRIDEiO04857.

    Structurei

    3D structure databases

    ProteinModelPortaliO04857.
    SMRiO04857. Positions 13-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O04857-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQNGQGIEP AVLDDIINRL LEFRNARTVR QVQLSEAEIR SLCTASKEIF    50
    LHQPNLLELE APIKICGDIH GQYGDLLRLF EYGGFPPEAN YLFLGDYVDR 100
    GKQSLETICL LLAYKIKYPE NFFLLRGNHE CASINRIYGF YDECKRRFNV 150
    RLWKTNTDCF NCLPVAALID DKILCMHGGL SPDLTDLDEI RNLPRPTDIP 200
    DSGLLCDLLW SDPSREVKGW GMNDRGVSYT FGSDKVAEFL MQHDMDLVCR 250
    AHQVVEDGYE FFAERQLVTI FSAPNYCGEF DNAGAMMSVD ENLMCSFQIL 300
    KPTDRKPRFL 310
    Length:310
    Mass (Da):35,435
    Last modified:July 1, 1997 - v1
    Checksum:i4EFA9FB525B7D4C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93769 mRNA. Translation: CAB07804.1.
    PIRiT03596.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93769 mRNA. Translation: CAB07804.1 .
    PIRi T03596.

    3D structure databases

    ProteinModelPortali O04857.
    SMRi O04857. Positions 13-309.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O04857.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple genes encoding serine/threonine protein phosphatases and their differential expression in Nicotiana tabacum."
      Suh M., Cho H., Kim Y., Liu J., Lee H.
      Plant Mol. Biol. 36:315-322(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Xanthi.

    Entry informationi

    Entry nameiPP12_TOBAC
    AccessioniPrimary (citable) accession number: O04857
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3