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O04856

- PP11_TOBAC

UniProt

O04856 - PP11_TOBAC

Protein

Serine/threonine-protein phosphatase PP1 isozyme 1

Gene

NPP1

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi75 – 751Manganese 1By similarity
    Metal bindingi77 – 771Manganese 1By similarity
    Metal bindingi103 – 1031Manganese 1By similarity
    Metal bindingi103 – 1031Manganese 2By similarity
    Metal bindingi135 – 1351Manganese 2By similarity
    Active sitei136 – 1361Proton donorBy similarity
    Metal bindingi184 – 1841Manganese 2By similarity
    Metal bindingi259 – 2591Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP1 isozyme 1 (EC:3.1.3.16)
    Gene namesi
    Name:NPP1
    OrganismiNicotiana tabacum (Common tobacco)
    Taxonomic identifieri4097 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Serine/threonine-protein phosphatase PP1 isozyme 1PRO_0000058811Add
    BLAST

    Proteomic databases

    PRIDEiO04856.

    Structurei

    3D structure databases

    ProteinModelPortaliO04856.
    SMRiO04856. Positions 20-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O04856-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQNNEQQQQ GQGLIEAGVL DDIINRLLEF RNARTVRQVQ LSEAEIRSLC    50
    SASREIFLQQ PNLLDLKPPI KICGDIHGQY GDLLRLFEYG GFPPEANYLF 100
    LGDYVDRGKQ SLETICLLLA YKIKYPENFF LLRGNHECAS INRIYGFYDE 150
    CKRRFNVKLW KCFTECFNCL PVAALIDEKI LCMHGGLSPV LTNLDQIRNL 200
    PRPTDVPDSG LLCDLLWSDP SREVKGWGMN DRGVSYTFGP DKVAEFLMQH 250
    DMDLVCRAHQ VVEDGYEFFA ERQLVTIFSA PNYCGEFDNA GAMMSVDESL 300
    MCSFQILKPT DRKPRFL 317
    Length:317
    Mass (Da):36,266
    Last modified:July 1, 1997 - v1
    Checksum:iC7613FE847CCDD36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93768 mRNA. Translation: CAB07803.1.
    PIRiT03594.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93768 mRNA. Translation: CAB07803.1 .
    PIRi T03594.

    3D structure databases

    ProteinModelPortali O04856.
    SMRi O04856. Positions 20-316.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O04856.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple genes encoding serine/threonine protein phosphatases and their differential expression in Nicotiana tabacum."
      Suh M., Cho H., Kim Y., Liu J., Lee H.
      Plant Mol. Biol. 36:315-322(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Xanthi.

    Entry informationi

    Entry nameiPP11_TOBAC
    AccessioniPrimary (citable) accession number: O04856
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3