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Protein

Serine/threonine-protein phosphatase PP1 isozyme 1

Gene

NPP1

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751Manganese 1By similarity
Metal bindingi77 – 771Manganese 1By similarity
Metal bindingi103 – 1031Manganese 1By similarity
Metal bindingi103 – 1031Manganese 2By similarity
Metal bindingi135 – 1351Manganese 2By similarity
Active sitei136 – 1361Proton donorBy similarity
Metal bindingi184 – 1841Manganese 2By similarity
Metal bindingi259 – 2591Manganese 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1 isozyme 1 (EC:3.1.3.16)
Gene namesi
Name:NPP1
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Serine/threonine-protein phosphatase PP1 isozyme 1PRO_0000058811Add
BLAST

Proteomic databases

PRIDEiO04856.

Structurei

3D structure databases

ProteinModelPortaliO04856.
SMRiO04856. Positions 20-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O04856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQNNEQQQQ GQGLIEAGVL DDIINRLLEF RNARTVRQVQ LSEAEIRSLC
60 70 80 90 100
SASREIFLQQ PNLLDLKPPI KICGDIHGQY GDLLRLFEYG GFPPEANYLF
110 120 130 140 150
LGDYVDRGKQ SLETICLLLA YKIKYPENFF LLRGNHECAS INRIYGFYDE
160 170 180 190 200
CKRRFNVKLW KCFTECFNCL PVAALIDEKI LCMHGGLSPV LTNLDQIRNL
210 220 230 240 250
PRPTDVPDSG LLCDLLWSDP SREVKGWGMN DRGVSYTFGP DKVAEFLMQH
260 270 280 290 300
DMDLVCRAHQ VVEDGYEFFA ERQLVTIFSA PNYCGEFDNA GAMMSVDESL
310
MCSFQILKPT DRKPRFL
Length:317
Mass (Da):36,266
Last modified:July 1, 1997 - v1
Checksum:iC7613FE847CCDD36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93768 mRNA. Translation: CAB07803.1.
PIRiT03594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93768 mRNA. Translation: CAB07803.1.
PIRiT03594.

3D structure databases

ProteinModelPortaliO04856.
SMRiO04856. Positions 20-316.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO04856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Multiple genes encoding serine/threonine protein phosphatases and their differential expression in Nicotiana tabacum."
    Suh M., Cho H., Kim Y., Liu J., Lee H.
    Plant Mol. Biol. 36:315-322(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Xanthi.

Entry informationi

Entry nameiPP11_TOBAC
AccessioniPrimary (citable) accession number: O04856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.