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O04719 (P2C77_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 2C 77

Short name=AtPP2C77
EC=3.1.3.16
Alternative name(s):
Protein ABSCISIC ACID-INSENSITIVE 2
Protein phosphatase 2C ABI2
Short name=PP2C ABI2
Gene names
Name:ABI2
Ordered Locus Names:At5g57050
ORF Names:MHM17.19
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, osmotic water permeability of the plasma membrane (Pos), high light stress, response to glucose, seed germination and inhibition of vegetative growth. During the stomatal closure regulation, modulates the inward calcium-channel permeability as well as H2O2 and oxidative burst in response to ABA and dehydration. Controls negatively fibrillin that is involved in mediating ABA-induced photoprotection. May be implicated in ABA content regulation. Involved in acquired thermotolerance of root growth and seedling survival. Required for the Erwinia amylovora harpin-induced (HrpN) drought tolerance. Involved in the hydrotropic response. Ref.1 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.19 Ref.20 Ref.21 Ref.22 Ref.24 Ref.27 Ref.29 Ref.30 Ref.32 Ref.35

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit. Ref.18

Enzyme regulation

Phosphatase activity repressed by oxidized ATGPX3, free fatty acids (e.g. arachidonic acid (20:4) and Linolenic acid (18:3)) and by H2O2. Repressed by PYR/PYL/RCAR ABA receptors in an ABA-dependent manner. Ref.18 Ref.38 Ref.39

Subunit structure

Interacts with CIPK15/PKS3, GPX3, SCAR1, SCAR2, SCAR3 and SCARL. Interacts also with CIPK24/SOS2. Binds to the fibrillin precursor protein. Interacts with ABA-bounded PYR1, PYL1, PYL2, PYL3, PYL4, PYL5, PYL6, PYL8 and PYL9, and with free PYL2, PYL3 and PYL4. Ref.17 Ref.23 Ref.31 Ref.32 Ref.33 Ref.37 Ref.38 Ref.39

Induction

Repressed by MYB44 and ERF4. Induced by salt stress and ABA. Ref.18 Ref.25 Ref.28 Ref.36 Ref.38 Ref.39

Domain

The 'lock' site stabilizes the complex made of PP2C, ABA and PYR/PYL/RCAR receptor by keeping receptor 'gate' and 'latch' loops in closed positions By similarity.

Miscellaneous

The reduced form of ABI2 is converted to the oxidized form by the addition of oxidized GPX3 or H2O2.

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Biophysicochemical properties

pH dependence:

Optimum pH is 8. Ref.18

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O04719-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O04719-2)

The sequence of this isoform differs from the canonical sequence as follows:
     29-68: Missing.
Note: Derived from EST data. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423Protein phosphatase 2C 77
PRO_0000057767

Regions

Domain111 – 404294PP2C-like

Sites

Metal binding1651Manganese 1 By similarity
Metal binding1651Manganese 2 By similarity
Metal binding1661Manganese 1; via carbonyl oxygen By similarity
Metal binding3371Manganese 2 By similarity
Metal binding4021Manganese 2 By similarity
Site2901Lock By similarity

Natural variations

Alternative sequence29 – 6840Missing in isoform 2.
VSP_034834

Experimental info

Mutagenesis1681G → D in abi2; reduced phosphatase activity, reduced affinity with magnesium ions, loss of interaction with the fibrillin precursor protein, impaired ABA-mediated binding to PYR1, and reduced negative control on fibrillin activity. Ref.1 Ref.32 Ref.38

Secondary structure

....................................................... 423
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 67CAAC76DA531A71

FASTA42346,306
        10         20         30         40         50         60 
MDEVSPAVAV PFRPFTDPHA GLRGYCNGES RVTLPESSCS GDGAMKDSSF EINTRQDSLT 

        70         80         90        100        110        120 
SSSSAMAGVD ISAGDEINGS DEFDPRSMNQ SEKKVLSRTE SRSLFEFKCV PLYGVTSICG 

       130        140        150        160        170        180 
RRPEMEDSVS TIPRFLQVSS SSLLDGRVTN GFNPHLSAHF FGVYDGHGGS QVANYCRERM 

       190        200        210        220        230        240 
HLALTEEIVK EKPEFCDGDT WQEKWKKALF NSFMRVDSEI ETVAHAPETV GSTSVVAVVF 

       250        260        270        280        290        300 
PTHIFVANCG DSRAVLCRGK TPLALSVDHK PDRDDEAARI EAAGGKVIRW NGARVFGVLA 

       310        320        330        340        350        360 
MSRSIGDRYL KPSVIPDPEV TSVRRVKEDD CLILASDGLW DVMTNEEVCD LARKRILLWH 

       370        380        390        400        410        420 
KKNAMAGEAL LPAEKRGEGK DPAAMSAAEY LSKMALQKGS KDNISVVVVD LKGIRKFKSK 


SLN 

« Hide

Isoform 2 [UniParc].

Checksum: 4E346383F40C3C34
Show »

FASTA38342,197

References

« Hide 'large scale' references
[1]"The Arabidopsis ABSCISIC ACID-INSENSITIVE2 (ABI2) and ABI1 genes encode homologous protein phosphatases 2C involved in abscisic acid signal transduction."
Leung J., Merlot S., Giraudat J.
Plant Cell 9:759-771(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, MUTAGENESIS OF GLY-168.
Strain: cv. Columbia and cv. Landsberg erecta.
[2]"ABI2, a second protein phosphatase 2C involved in abscisic acid signal transduction in Arabidopsis."
Rodriguez P.L., Benning G., Grill E.
FEBS Lett. 421:185-190(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Landsberg erecta.
[3]"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[4]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[5]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[6]"Maternal effects govern variable dominance of two abscisic acid response mutations in Arabidopsis thaliana."
Finkelstein R.R.
Plant Physiol. 105:1203-1208(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Abscisic acid induces the alcohol dehydrogenase gene in Arabidopsis."
de Bruxelles G.L., Peacock W.J., Dennis E.S., Dolferus R.
Plant Physiol. 111:381-391(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Abscisic acid-independent and abscisic acid-dependent regulation of proline biosynthesis following cold and osmotic stresses in Arabidopsis thaliana."
Savoure A., Hua X.-J., Bertauche N., Van Montagu M., Verbruggen N.
Mol. Gen. Genet. 254:104-109(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"Differential abscisic acid regulation of guard cell slow anion channels in Arabidopsis wild-type and abi1 and abi2 mutants."
Pei Z.-M., Kuchitsu K., Ward J.M., Schwarz M., Schroeder J.I.
Plant Cell 9:409-423(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[10]"Convergence of the abscisic acid, CO2, and extracellular calcium signal transduction pathways in stomatal guard cells."
Webb A.A.R., Hetherington A.M.
Plant Physiol. 114:1557-1560(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[11]"Arabidopsis abi1-1 and abi2-1 phosphatase mutations reduce abscisic acid-induced cytoplasmic calcium rises in guard cells."
Allen G.J., Kuchitsu K., Chu S.P., Murata Y., Schroeder J.I.
Plant Cell 11:1785-1798(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]"Analysis of Arabidopsis glucose insensitive mutants, gin5 and gin6, reveals a central role of the plant hormone ABA in the regulation of plant vegetative development by sugar."
Arenas-Huertero F., Arroyo A., Zhou L., Sheen J., Leon P.
Genes Dev. 14:2085-2096(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[13]"The genes ABI1 and ABI2 are involved in abscisic acid- and drought-inducible expression of the Daucus carota L. Dc3 promoter in guard cells of transgenic Arabidopsis thaliana (L.) Heynh."
Chak R.K.F., Thomas T.L., Quatrano R.S., Rock C.D.
Planta 210:875-883(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[14]"Abscisic acid activation of plasma membrane Ca(2+) channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in abi1-1 and abi2-1 protein phosphatase 2C mutants."
Murata Y., Pei Z.-M., Mori I.C., Schroeder J.
Plant Cell 13:2513-2523(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[15]"The ABI1 and ABI2 protein phosphatases 2C act in a negative feedback regulatory loop of the abscisic acid signalling pathway."
Merlot S., Gosti F., Guerrier D., Vavasseur A., Giraudat J.
Plant J. 25:295-303(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[16]"The role of ABA and the transpiration stream in the regulation of the osmotic water permeability of leaf cells."
Morillon R., Chrispeels M.J.
Proc. Natl. Acad. Sci. U.S.A. 98:14138-14143(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[17]"A calcium sensor and its interacting protein kinase are global regulators of abscisic acid signaling in Arabidopsis."
Guo Y., Xiong L., Song C.-P., Gong D., Halfter U., Zhu J.-K.
Dev. Cell 3:233-244(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CIPK15/PKS3.
[18]"The sensitivity of ABI2 to hydrogen peroxide links the abscisic acid-response regulator to redox signalling."
Meinhard M., Rodriguez P.L., Grill E.
Planta 214:775-782(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: COFACTOR, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
[19]"Hydrotropism in abscisic acid, wavy, and gravitropic mutants of Arabidopsis thaliana."
Takahashi N., Goto N., Okada K., Takahashi H.
Planta 216:203-211(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[20]"Hypersensitivity of abscisic acid-induced cytosolic calcium increases in the Arabidopsis farnesyltransferase mutant era1-2."
Allen G.J., Murata Y., Chu S.P., Nafisi M., Schroeder J.I.
Plant Cell 14:1649-1662(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[21]"Regulation of the ABA-sensitive Arabidopsis potassium channel gene GORK in response to water stress."
Becker D., Hoth S., Ache P., Wenkel S., Roelfsema M.R.G., Meyerhoff O., Hartung W., Hedrich R.
FEBS Lett. 554:119-126(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[22]"Control of Ascorbate Peroxidase 2 expression by hydrogen peroxide and leaf water status during excess light stress reveals a functional organisation of Arabidopsis leaves."
Fryer M.J., Ball L., Oxborough K., Karpinski S., Mullineaux P.M., Baker N.R.
Plant J. 33:691-705(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[23]"A novel domain in the protein kinase SOS2 mediates interaction with the protein phosphatase 2C ABI2."
Ohta M., Guo Y., Halfter U., Zhu J.-K.
Proc. Natl. Acad. Sci. U.S.A. 100:11771-11776(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CIPK24/SOS2.
[24]"Synthesis of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is concertedly regulated by metabolic and stress-associated signals."
Stepansky A., Galili G.
Plant Physiol. 133:1407-1415(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[25]"Gain-of-function and loss-of-function phenotypes of the protein phosphatase 2C HAB1 reveal its role as a negative regulator of abscisic acid signalling."
Saez A., Apostolova N., Gonzalez-Guzman M., Gonzalez-Garcia M.P., Nicolas C., Lorenzo O., Rodriguez P.L.
Plant J. 37:354-369(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY ABA.
[26]"Plant PP2C phosphatases: emerging functions in stress signaling."
Schweighofer A., Hirt H., Meskiene I.
Trends Plant Sci. 9:236-243(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[27]"The ABI2-dependent abscisic acid signalling controls HrpN-induced drought tolerance in Arabidopsis."
Dong H.-P., Yu H., Bao Z., Guo X., Peng J., Yao Z., Chen G., Qu S., Dong H.
Planta 221:313-327(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[28]"Arabidopsis ERF4 is a transcriptional repressor capable of modulating ethylene and abscisic acid responses."
Yang Z., Tian L., Latoszek-Green M., Brown D., Wu K.
Plant Mol. Biol. 58:585-596(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY ERF4.
[29]"Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance."
Larkindale J., Hall J.D., Knight M.R., Vierling E.
Plant Physiol. 138:882-897(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[30]"Role of abscisic acid (ABA) and Arabidopsis thaliana ABA-insensitive loci in low water potential-induced ABA and proline accumulation."
Verslues P.E., Bray E.A.
J. Exp. Bot. 57:201-212(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[31]"An Arabidopsis glutathione peroxidase functions as both a redox transducer and a scavenger in abscisic acid and drought stress responses."
Miao Y., Lv D., Wang P., Wang X.-C., Chen J., Miao C., Song C.-P.
Plant Cell 18:2749-2766(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GPX3, REPRESSION BY OXIDIZED GPX3.
[32]"Fibrillin expression is regulated by abscisic acid response regulators and is involved in abscisic acid-mediated photoprotection."
Yang Y., Sulpice R., Himmelbach A., Meinhard M., Christmann A., Grill E.
Proc. Natl. Acad. Sci. U.S.A. 103:6061-6066(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF GLY-168, INTERACTION WITH THE FIBRILLIN PRECURSOR PROTEIN.
[33]"The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis."
Uhrig J.F., Mutondo M., Zimmermann I., Deeks M.J., Machesky L.M., Thomas P., Uhrig S., Rambke C., Hussey P.J., Huelskamp M.
Development 134:967-977(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SCAR1; SCAR2; SCAR3 AND SCARL.
[34]"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[35]"Interaction between sugar and abscisic acid signalling during early seedling development in Arabidopsis."
Dekkers B.J.W., Schuurmans J.A.M.J., Smeekens S.C.M.
Plant Mol. Biol. 67:151-167(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[36]"Overexpression of AtMYB44 enhances stomatal closure to confer abiotic stress tolerance in transgenic Arabidopsis."
Jung C., Seo J.S., Han S.W., Koo Y.J., Kim C.H., Song S.I., Nahm B.H., Choi Y.D., Cheong J.-J.
Plant Physiol. 146:623-635(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY MYB44 AND SALT.
[37]"Regulators of PP2C phosphatase activity function as abscisic acid sensors."
Ma Y., Szostkiewicz I., Korte A., Moes D., Yang Y., Christmann A., Grill E.
Science 324:1064-1068(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PYL9/RCAR1.
[38]"Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins."
Park S.-Y., Fung P., Nishimura N., Jensen D.R., Fujii H., Zhao Y., Lumba S., Santiago J., Rodrigues A., Chow T.F., Alfred S.E., Bonetta D., Finkelstein R., Provart N.J., Desveaux D., Rodriguez P.L., McCourt P., Zhu J.-K. expand/collapse author list , Schroeder J.I., Volkman B.F., Cutler S.R.
Science 324:1068-1071(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PYR1; PYL1; PYL2; PYL3 AND PYL4, ENZYME REGULATION, MUTAGENESIS OF GLY-168.
[39]"Closely related receptor complexes differ in their ABA selectivity and sensitivity."
Szostkiewicz I., Richter K., Kepka M., Demmel S., Ma Y., Korte A., Assaad F.F., Christmann A., Grill E.
Plant J. 61:25-35(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PYL8/RCAR3, ENZYME REGULATION BY PYR/PYL/RCAR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08966 Genomic DNA. Translation: CAA70163.1.
Y08965 mRNA. Translation: CAA70162.1.
Y11840 Genomic DNA. Translation: CAA72538.1.
AB024035 Genomic DNA. Translation: BAA97035.1.
CP002688 Genomic DNA. Translation: AED96839.1.
CP002688 Genomic DNA. Translation: AED96840.1.
AY136415 mRNA. Translation: AAM97081.1.
BT008860 mRNA. Translation: AAP68299.1.
RefSeqNP_001119448.1. NM_001125976.1. [O04719-2]
NP_200515.1. NM_125087.2. [O04719-1]
UniGeneAt.22051.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3NMVX-ray2.10B101-423[»]
3UJKX-ray1.90A101-423[»]
3UJLX-ray2.50B101-423[»]
ProteinModelPortalO04719.
SMRO04719. Positions 103-415.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid21053. 14 interactions.
DIPDIP-35025N.
IntActO04719. 8 interactions.
MINTMINT-274841.

Proteomic databases

PaxDbO04719.
PRIDEO04719.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G57050.1; AT5G57050.1; AT5G57050. [O04719-1]
GeneID835809.
KEGGath:AT5G57050.

Organism-specific databases

TAIRAT5G57050.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000233896.
InParanoidO04719.
KOK14497.
OMAFEINTRQ.
PhylomeDBO04719.

Enzyme and pathway databases

BioCycARA:AT5G57050-MONOMER.
ARA:GQT-1437-MONOMER.

Gene expression databases

GenevestigatorO04719.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO04719.

Entry information

Entry nameP2C77_ARATH
AccessionPrimary (citable) accession number: O04719
Secondary accession number(s): B3H561
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: June 11, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names