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Protein

Mitochondrial adenine nucleotide transporter ADNT1

Gene

ADNT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial adenylate carrier that catalyzes specifically the transport of ATP, ADP and AMP by a counter-exchange mechanism across the inner mitochondrial membrane. Substrate preference in reconstituted proteoliposomes is ATP > AMP > ADP. May play a role in oxidative phosphorylation and be important for the provision of energy required to support growth in heterotrophic tissues.1 Publication

Enzyme regulationi

Inhibited by pyridoxal 5-phosphate, bathophenanthroline, mersalyl, p-hydroxymercuribenzoate and tannic acid.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.23.4. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial adenine nucleotide transporter ADNT1
Alternative name(s):
Adenine nucleotide transporter 1
Gene namesi
Name:ADNT1
Ordered Locus Names:At4g01100
ORF Names:A_IG002N01.16, F2N1.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G01100.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei145 – 16218Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei202 – 22120Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei242 – 26322Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei324 – 34017Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Reduced root growth and respiration.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Mitochondrial adenine nucleotide transporter ADNT1PRO_0000420757Add
BLAST

Proteomic databases

PaxDbiO04619.
PRIDEiO04619.

PTM databases

iPTMnetiO04619.

Expressioni

Tissue specificityi

Expressed in seedling radicles and roots, vasculature of cotyledons, leaf primordia, leaves and sepals.1 Publication

Gene expression databases

ExpressionAtlasiO04619. baseline and differential.
GenevisibleiO04619. AT.

Interactioni

Protein-protein interaction databases

IntActiO04619. 1 interaction.
STRINGi3702.AT4G01100.2.

Structurei

3D structure databases

ProteinModelPortaliO04619.
SMRiO04619. Positions 41-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 12388Solcar 1Add
BLAST
Repeati139 – 22789Solcar 2Add
BLAST
Repeati242 – 343102Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
HOGENOMiHOG000165726.
InParanoidiO04619.
KOiK14684.
PhylomeDBiO04619.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: O04619-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASEDVKRTE SAAVSTIVNL AEEAREGVKA PSYAFKSICK SLFAGGVAGG
60 70 80 90 100
VSRTAVAPLE RMKILLQVQN PHNIKYSGTV QGLKHIWRTE GLRGLFKGNG
110 120 130 140 150
TNCARIVPNS AVKFFSYEQA SNGILYMYRQ RTGNENAQLT PLLRLGAGAT
160 170 180 190 200
AGIIAMSATY PMDMVRGRLT VQTANSPYQY RGIAHALATV LREEGPRALY
210 220 230 240 250
RGWLPSVIGV VPYVGLNFSV YESLKDWLVK ENPYGLVENN ELTVVTRLTC
260 270 280 290 300
GAIAGTVGQT IAYPLDVIRR RMQMVGWKDA SAIVTGEGRS TASLEYTGMV
310 320 330 340 350
DAFRKTVRHE GFGALYKGLV PNSVKVVPSI AIAFVTYEMV KDVLGVEFRI

SD
Length:352
Mass (Da):38,325
Last modified:July 1, 1997 - v1
Checksum:i360CA4785EFB4A8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM931440 mRNA. Translation: CAP64296.1.
AF007269 Genomic DNA. Translation: AAB61037.1.
AL161491 Genomic DNA. Translation: CAB80919.1.
CP002687 Genomic DNA. Translation: AEE81981.1.
AF360168 mRNA. Translation: AAK25878.1.
AF412085 mRNA. Translation: AAL06538.1.
AY056343 mRNA. Translation: AAL07192.1.
PIRiT01729.
RefSeqiNP_192019.1. NM_116340.3. [O04619-1]
UniGeneiAt.19620.
At.71232.

Genome annotation databases

EnsemblPlantsiAT4G01100.1; AT4G01100.1; AT4G01100. [O04619-1]
GeneIDi827899.
KEGGiath:AT4G01100.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM931440 mRNA. Translation: CAP64296.1.
AF007269 Genomic DNA. Translation: AAB61037.1.
AL161491 Genomic DNA. Translation: CAB80919.1.
CP002687 Genomic DNA. Translation: AEE81981.1.
AF360168 mRNA. Translation: AAK25878.1.
AF412085 mRNA. Translation: AAL06538.1.
AY056343 mRNA. Translation: AAL07192.1.
PIRiT01729.
RefSeqiNP_192019.1. NM_116340.3. [O04619-1]
UniGeneiAt.19620.
At.71232.

3D structure databases

ProteinModelPortaliO04619.
SMRiO04619. Positions 41-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO04619. 1 interaction.
STRINGi3702.AT4G01100.2.

Protein family/group databases

TCDBi2.A.29.23.4. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiO04619.

Proteomic databases

PaxDbiO04619.
PRIDEiO04619.

Protocols and materials databases

DNASUi827899.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G01100.1; AT4G01100.1; AT4G01100. [O04619-1]
GeneIDi827899.
KEGGiath:AT4G01100.

Organism-specific databases

TAIRiAT4G01100.

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
HOGENOMiHOG000165726.
InParanoidiO04619.
KOiK14684.
PhylomeDBiO04619.

Miscellaneous databases

PROiO04619.

Gene expression databases

ExpressionAtlasiO04619. baseline and differential.
GenevisibleiO04619. AT.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of ADNT1, a novel mitochondrial adenine nucleotide transporter from Arabidopsis."
    Palmieri L., Santoro A., Carrari F., Blanco E., Nunes-Nesi A., Arrigoni R., Genchi F., Fernie A.R., Palmieri F.
    Plant Physiol. 148:1797-1808(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    Strain: cv. Landsberg erecta.
  2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiADNT1_ARATH
AccessioniPrimary (citable) accession number: O04619
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: July 1, 1997
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.