O04500 (COBL6_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
COBRA-like protein 6

Gene names

Name:	COBL6
Ordered Locus Names:	At1g09790
ORF Names:	F21M12.17, F21M12_18

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Potential.
Tissue specificity	Expressed in flowers and siliques. Ref.4
Sequence similarities	Belongs to the COBRA family.
Sequence caution	The sequence AAB60732.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
PTM	GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	anchored to membrane Traceable author statement PubMed 12068095Ref.4PubMed 12805588. Source: TAIR plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 429	405	COBRA-like protein 6		PRO_0000005579
	Propeptide	430 – 454	25	Removed in mature form Potential		PRO_0000005580
Amino acid modifications
	Lipidation	429	1	GPI-anchor amidated serine Potential
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	191	1	N-linked (GlcNAc...) Potential
	Glycosylation	320	1	N-linked (GlcNAc...) Potential
	Glycosylation	355	1	N-linked (GlcNAc...) Potential
	Glycosylation	391	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O04500 [UniParc]. Last modified August 22, 2003. Version 2. Checksum: 163BD35FA7EB65B4	FASTA	454	50,954
	10 20 30 40 50 60 MGAMLNLLLV VTVILCSILS PTRFMIMIDK MVADGYDPLD PFGKIIIKWD LLLSSPGQHH 70 80 90 100 110 120 VQVTLENMQE YRHVEKPGWK LSWHWLNQEV IWDMKGAETT EQGNCSAFAS SGNLPHCCLE 130 140 150 160 170 180 RPTIVDLLPG ASLNVQVANC CRGGVLTSMS QDHANHVSAF HMTVGSSPDG PEEFNMPSNF 190 200 210 220 230 240 DIGVPGYSCD NATSVSPTKF STDKGRRKTQ ALATWEAVCV YSQFRSSPSP KCCVSLSAFY 250 260 270 280 290 300 YQNIVPCPTC SCGCSSSHCV KDGELPPYLE QKHDPDEEVS PVVKCSDHMC PIRIHWHVKV 310 320 330 340 350 360 NYREYWRVKI TATNFNTMKN YTNWNLVVLH PNLKSVQQVF SFNYKSLTPY QNSINDTGMF 370 380 390 400 410 420 WGVQFYNDVL LQEGKIGNVQ TELLLKKDMG NFTFREGWAF PRRILFNGDE CVMPSPDDFP 430 440 450 RLPKSAHSSS SSSAVISSVS VVFCFLLHHL LLLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	Haas B. Unpublished observations (JUL-2003) Cited for: CONCEPTUAL TRANSLATION.
[4]	"The COBRA family of putative GPI-anchored proteins in Arabidopsis. A new fellowship in expansion." Roudier F., Schindelman G., DeSalle R., Benfey P.N. Plant Physiol. 130:538-548(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC000132 Genomic DNA. Translation: AAB60732.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE28492.1.
IPI	IPI00542498.
PIR	H86231.
RefSeq	NP_172450.2. NM_100851.2.
UniGene	At.42212.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT1G09790.1-P.
Proteomic databases
PaxDb	O04500.
PRIDE	O04500.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G09790.1; AT1G09790.1; AT1G09790.
GeneID	837508.
KEGG	ath:AT1G09790.
Organism-specific databases
GeneFarm	1671. 91.
TAIR	At1g09790.
Phylogenomic databases
eggNOG	NOG330624.
HOGENOM	HOG000231433.
InParanoid	O04500.
OMA	NDTGMFW.
PhylomeDB	O04500.
ProtClustDB	CLSN2918052.
Gene expression databases
Genevestigator	O04500.
GermOnline	AT1G09790. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR017391. COBRA-like. IPR006918. GPI-anchored_pln. [Graphical view]
Pfam	PF04833. COBRA. 1 hit. [Graphical view]
PIRSF	PIRSF038122. COBRA. 1 hit.
ProDom	PD140986. GPI-anchored_pln. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

COBL6_ARATH

Accession

Primary (citable) accession number: O04500

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	August 22, 2003
Last modified:	May 1, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program