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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1

Gene

PGM1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.By similarity

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic (GAPC2), Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic (GAPC1)
  2. Phosphoglycerate kinase 3, cytosolic (PGK3)
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (At3g08590), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (PGM1)
  4. Enolase 1, chloroplastic (ENO1), Cytosolic enolase 3 (ENO3), Bifunctional enolase 2/transcriptional activator (ENO2)
  5. Pyruvate kinase (AXX17_At3g24740), Pyruvate kinase (AXX17_At5g51800), Pyruvate kinase (AXX17_At5g63250), Pyruvate kinase (AXX17_At3g50280), Pyruvate kinase (AXX17_ATUG04870), Pyruvate kinase (MAH20.13), Pyruvate kinase (MCD7.8), Pyruvate kinase (MBK5.16), Pyruvate kinase (F1I16_60), Pyruvate kinase (At3g25960), Pyruvate kinase (AXX17_At3g50440), Plastidial pyruvate kinase 3, chloroplastic (PKP3), Pyruvate kinase (AXX17_At5g08490), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At5g55530), Pyruvate kinase (AXX17_At3g28070), Pyruvate kinase (At2g36580), Pyruvate kinase (AXX17_At3g47400), Pyruvate kinase, Probable pyruvate kinase, cytosolic isozyme (At4g26390), Pyruvate kinase (F8J2_160), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At3g03460), Plastidial pyruvate kinase 2 (PKP2), Pyruvate kinase (AXX17_At2g33300), Pyruvate kinase (At3g04050), Pyruvate kinase (AXX17_At4g30430), Pyruvate kinase (F1I16_220), Plastidial pyruvate kinase 1, chloroplastic (PKP1), Pyruvate kinase (AXX17_At1g33230), Pyruvate kinase (At5g63680), Pyruvate kinase, Plastidial pyruvate kinase 4, chloroplastic (PKP4)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Manganese 2By similarity1
Active sitei80Phosphoserine intermediateBy similarity1
Metal bindingi80Manganese 2By similarity1
Binding sitei139SubstrateBy similarity1
Binding sitei205SubstrateBy similarity1
Binding sitei212SubstrateBy similarity1
Binding sitei360SubstrateBy similarity1
Metal bindingi429Manganese 1By similarity1
Metal bindingi433Manganese 1By similarity1
Metal bindingi470Manganese 2By similarity1
Metal bindingi471Manganese 2By similarity1
Metal bindingi500Manganese 1By similarity1

GO - Molecular functioni

  • 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: TAIR
  • manganese ion binding Source: InterPro

GO - Biological processi

  • glucose catabolic process Source: InterPro
  • glycolytic process Source: UniProtKB-UniPathway
  • pollen development Source: TAIR
  • response to cadmium ion Source: TAIR
  • response to cold Source: TAIR
  • stomatal movement Source: TAIR

Keywordsi

Molecular functionIsomerase
Biological processGlycolysis
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G09780-MONOMER
BRENDAi5.4.2.12 399
UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (EC:5.4.2.12)
Short name:
BPG-independent PGAM 1
Short name:
Phosphoglyceromutase 1
Alternative name(s):
PGAM-I 1
Gene namesi
Name:PGM1
Ordered Locus Names:At1g09780
ORF Names:F21M12.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G09780
TAIRilocus:2024357 AT1G09780

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002121081 – 5572,3-bisphosphoglycerate-independent phosphoglycerate mutase 1Add BLAST557

Proteomic databases

PaxDbiO04499
PRIDEiO04499

PTM databases

iPTMnetiO04499

Expressioni

Gene expression databases

ExpressionAtlasiO04499 baseline and differential
GenevisibleiO04499 AT

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi3702.AT1G09780.1

Structurei

3D structure databases

ProteinModelPortaliO04499
SMRiO04499
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni169 – 170Substrate bindingBy similarity2
Regioni285 – 288Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4513 Eukaryota
COG0696 LUCA
HOGENOMiHOG000223664
InParanoidiO04499
KOiK15633
OMAiFMDGRDT
OrthoDBiEOG093605CN
PhylomeDBiO04499

Family and domain databases

CDDicd16010 iPGM, 1 hit
Gene3Di3.40.1450.101 hit
3.40.720.102 hits
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR011258 BPG-indep_PGM_N
IPR006124 Metalloenzyme
IPR036646 PGAM_B_sf
IPR005995 Pgm_bpd_ind
PANTHERiPTHR31637 PTHR31637, 1 hit
PfamiView protein in Pfam
PF06415 iPGM_N, 1 hit
PF01676 Metalloenzyme, 1 hit
PIRSFiPIRSF001492 IPGAM, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits
SSF64158 SSF64158, 1 hit
TIGRFAMsiTIGR01307 pgm_bpd_ind, 1 hit

Sequencei

Sequence statusi: Complete.

O04499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSSAWKLD DHPKLPKGKT IAVIVLDGWG ESAPDQYNCI HNAPTPAMDS
60 70 80 90 100
LKHGAPDTWT LIKAHGTAVG LPSEDDMGNS EVGHNALGAG RIFAQGAKLC
110 120 130 140 150
DQALASGKIF EGEGFKYVSE SFETNTLHLV GLLSDGGVHS RLDQLQLLIK
160 170 180 190 200
GSAERGAKRI RVHILTDGRD VLDGSSVGFV ETLEADLVAL RENGVDAQIA
210 220 230 240 250
SGGGRMYVTL DRYENDWEVV KRGWDAQVLG EAPHKFKNAV EAVKTLRKEP
260 270 280 290 300
GANDQYLPPF VIVDESGKAV GPIVDGDAVV TFNFRADRMV MHAKALEYED
310 320 330 340 350
FDKFDRVRYP KIRYAGMLQY DGELKLPSRY LVSPPEIDRT SGEYLTHNGV
360 370 380 390 400
STFACSETVK FGHVTFFWNG NRSGYFNEKL EEYVEIPSDS GISFNVQPKM
410 420 430 440 450
KALEIGEKAR DAILSGKFDQ VRVNIPNGDM VGHTGDIEAT VVACEAADLA
460 470 480 490 500
VKMIFDAIEQ VKGIYVVTAD HGNAEDMVKR DKSGKPALDK EGKLQILTSH
510 520 530 540 550
TLKPVPIAIG GPGLAQGVRF RKDLETPGLA NVAATVMNLH GFVAPSDYEP

TLIEVVE
Length:557
Mass (Da):60,580
Last modified:April 30, 2003 - v3
Checksum:iD5FC3D06A963B9AB
GO

Sequence cautioni

The sequence AAB60731 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC000132 Genomic DNA Translation: AAB60731.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28491.1
AY150432 mRNA Translation: AAN12974.1
BT000773 mRNA Translation: AAN31912.1
AY086182 mRNA Translation: AAM64261.1
PIRiG86231
RefSeqiNP_563852.1, NM_100850.3
UniGeneiAt.24465

Genome annotation databases

EnsemblPlantsiAT1G09780.1; AT1G09780.1; AT1G09780
GeneIDi837507
GrameneiAT1G09780.1; AT1G09780.1; AT1G09780
KEGGiath:AT1G09780

Similar proteinsi

Entry informationi

Entry nameiPMG1_ARATH
AccessioniPrimary (citable) accession number: O04499
Secondary accession number(s): Q8LD62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 30, 2003
Last modified: April 25, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome