ID   RAA2A_ARATH             Reviewed;         217 AA.
AC   O04486;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   27-MAR-2024, entry version 169.
DE   RecName: Full=Ras-related protein RABA2a;
DE            Short=AtRABA2a;
DE   AltName: Full=Ras-related protein Rab11C;
DE            Short=AtRab11C;
DE   Flags: Precursor;
GN   Name=RABA2A; Synonyms=RAB11C; OrderedLocusNames=At1g09630;
GN   ORFNames=F21M12.2;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia;
RA   Bischoff F., Palme K.;
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12644670; DOI=10.1104/pp.013052;
RA   Vernoud V., Horton A.C., Yang Z., Nielsen E.;
RT   "Analysis of the small GTPase gene superfamily of Arabidopsis.";
RL   Plant Physiol. 131:1191-1208(2003).
RN   [7]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=18239134; DOI=10.1105/tpc.107.052001;
RA   Chow C.M., Neto H., Foucart C., Moore I.;
RT   "Rab-A2 and Rab-A3 GTPases define a trans-Golgi endosomal membrane domain
RT   in Arabidopsis that contributes substantially to the cell plate.";
RL   Plant Cell 20:101-123(2008).
CC   -!- FUNCTION: Intracellular vesicle trafficking and protein transport.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:18239134}.
CC       Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000305|PubMed:18239134}; Lipid-anchor
CC       {ECO:0000305|PubMed:18239134}. Note=During cytokinesis located to the
CC       growing margins of the cell plate.
CC   -!- TISSUE SPECIFICITY: Expressed in root tips.
CC       {ECO:0000269|PubMed:18239134}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; U74669; AAB61994.1; -; mRNA.
DR   EMBL; AC000132; AAB60720.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE28471.1; -; Genomic_DNA.
DR   EMBL; AY045620; AAK73978.1; -; mRNA.
DR   EMBL; AY133657; AAM91487.1; -; mRNA.
DR   EMBL; AY085684; AAM62903.1; -; mRNA.
DR   PIR; A86230; A86230.
DR   RefSeq; NP_172434.1; NM_100835.3.
DR   AlphaFoldDB; O04486; -.
DR   SMR; O04486; -.
DR   BioGRID; 22731; 3.
DR   IntAct; O04486; 4.
DR   MINT; O04486; -.
DR   STRING; 3702.O04486; -.
DR   iPTMnet; O04486; -.
DR   PaxDb; 3702-AT1G09630-1; -.
DR   ProteomicsDB; 236612; -.
DR   EnsemblPlants; AT1G09630.1; AT1G09630.1; AT1G09630.
DR   GeneID; 837490; -.
DR   Gramene; AT1G09630.1; AT1G09630.1; AT1G09630.
DR   KEGG; ath:AT1G09630; -.
DR   Araport; AT1G09630; -.
DR   TAIR; AT1G09630; RAB11C.
DR   eggNOG; KOG0087; Eukaryota.
DR   HOGENOM; CLU_041217_23_0_1; -.
DR   InParanoid; O04486; -.
DR   OMA; THKEDEY; -.
DR   OrthoDB; 152at2759; -.
DR   PhylomeDB; O04486; -.
DR   PRO; PR:O04486; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; O04486; baseline and differential.
DR   GO; GO:0009504; C:cell plate; IDA:TAIR.
DR   GO; GO:0005768; C:endosome; IDA:TAIR.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; HDA:TAIR.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0000911; P:cytokinesis by cell plate formation; IMP:TAIR.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd01868; Rab11_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR47979; DRAB11-RELATED; 1.
DR   PANTHER; PTHR47979:SF142; RAS-RELATED PROTEIN RABA2A; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00176; RAN; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   Genevisible; O04486; AT.
PE   2: Evidence at transcript level;
KW   Endosome; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation;
KW   Nucleotide-binding; Palmitate; Prenylation; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..214
FT                   /note="Ras-related protein RABA2a"
FT                   /id="PRO_0000121165"
FT   PROPEP          215..217
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000370754"
FT   MOTIF           41..49
FT                   /note="Effector region"
FT                   /evidence="ECO:0000250"
FT   BINDING         19..26
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         67..71
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         125..128
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         155..156
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         214
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000255"
FT   LIPID           213
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           214
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   217 AA;  24108 MW;  D8DBFD3192FD92C8 CRC64;
     MARRPDEEYD YLFKVVLIGD SGVGKSNLLS RFTRNEFCLE SKSTIGVEFA TRTLQVEGRT
     VKAQIWDTAG QERYRAITSA YYRGALGALL VYDVTKPTTF ENVSRWLKEL RDHADSNIVI
     MLIGNKTDLK HLRAVATEDA QSYAEKEGLS FIETSALEAL NVEKAFQTIL SEVYRIISKK
     SISSDQTTAN ANIKEGQTID VAATSESNAK KPCCSSS
//