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O04486

- RAA2A_ARATH

UniProt

O04486 - RAA2A_ARATH

Protein

Ras-related protein RABA2a

Gene

RABA2A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Intracellular vesicle trafficking and protein transport.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 268GTPBy similarity
    Nucleotide bindingi67 – 715GTPBy similarity
    Nucleotide bindingi125 – 1284GTPBy similarity
    Nucleotide bindingi155 – 1562GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein RABA2a
    Short name:
    AtRABA2a
    Alternative name(s):
    Ras-related protein Rab11C
    Short name:
    AtRab11C
    Gene namesi
    Name:RABA2A
    Synonyms:RAB11C
    Ordered Locus Names:At1g09630
    ORF Names:F21M12.2
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G09630.

    Subcellular locationi

    Endosome membrane 1 Publication. Golgi apparatustrans-Golgi network membrane 1 Publication; Lipid-anchor 1 Publication
    Note: During cytokinesis located to the growing margins of the cell plate.

    GO - Cellular componenti

    1. cell plate Source: TAIR
    2. cytosol Source: TAIR
    3. endosome Source: TAIR
    4. endosome membrane Source: UniProtKB-SubCell
    5. Golgi apparatus Source: UniProtKB-SubCell
    6. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 214213Ras-related protein RABA2aPRO_0000121165Add
    BLAST
    Propeptidei215 – 2173Removed in mature formSequence AnalysisPRO_0000370754

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi213 – 2131S-palmitoyl cysteineBy similarity
    Modified residuei214 – 2141Cysteine methyl esterSequence Analysis
    Lipidationi214 – 2141S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Palmitate, Prenylation

    Proteomic databases

    PaxDbiO04486.
    PRIDEiO04486.

    Expressioni

    Tissue specificityi

    Expressed in root tips.1 Publication

    Gene expression databases

    GenevestigatoriO04486.

    Interactioni

    Protein-protein interaction databases

    BioGridi22731. 3 interactions.
    IntActiO04486. 4 interactions.
    MINTiMINT-7712599.
    STRINGi3702.AT1G09630.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliO04486.
    SMRiO04486. Positions 9-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 499Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    InParanoidiO04486.
    KOiK07904.
    OMAiAKKPCCS.
    PhylomeDBiO04486.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O04486-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARRPDEEYD YLFKVVLIGD SGVGKSNLLS RFTRNEFCLE SKSTIGVEFA    50
    TRTLQVEGRT VKAQIWDTAG QERYRAITSA YYRGALGALL VYDVTKPTTF 100
    ENVSRWLKEL RDHADSNIVI MLIGNKTDLK HLRAVATEDA QSYAEKEGLS 150
    FIETSALEAL NVEKAFQTIL SEVYRIISKK SISSDQTTAN ANIKEGQTID 200
    VAATSESNAK KPCCSSS 217
    Length:217
    Mass (Da):24,108
    Last modified:July 1, 1997 - v1
    Checksum:iD8DBFD3192FD92C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U74669 mRNA. Translation: AAB61994.1.
    AC000132 Genomic DNA. Translation: AAB60720.1.
    CP002684 Genomic DNA. Translation: AEE28471.1.
    AY045620 mRNA. Translation: AAK73978.1.
    AY133657 mRNA. Translation: AAM91487.1.
    AY085684 mRNA. Translation: AAM62903.1.
    PIRiA86230.
    RefSeqiNP_172434.1. NM_100835.2.
    UniGeneiAt.20265.

    Genome annotation databases

    EnsemblPlantsiAT1G09630.1; AT1G09630.1; AT1G09630.
    GeneIDi837490.
    KEGGiath:AT1G09630.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U74669 mRNA. Translation: AAB61994.1 .
    AC000132 Genomic DNA. Translation: AAB60720.1 .
    CP002684 Genomic DNA. Translation: AEE28471.1 .
    AY045620 mRNA. Translation: AAK73978.1 .
    AY133657 mRNA. Translation: AAM91487.1 .
    AY085684 mRNA. Translation: AAM62903.1 .
    PIRi A86230.
    RefSeqi NP_172434.1. NM_100835.2.
    UniGenei At.20265.

    3D structure databases

    ProteinModelPortali O04486.
    SMRi O04486. Positions 9-176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 22731. 3 interactions.
    IntActi O04486. 4 interactions.
    MINTi MINT-7712599.
    STRINGi 3702.AT1G09630.1-P.

    Proteomic databases

    PaxDbi O04486.
    PRIDEi O04486.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G09630.1 ; AT1G09630.1 ; AT1G09630 .
    GeneIDi 837490.
    KEGGi ath:AT1G09630.

    Organism-specific databases

    TAIRi AT1G09630.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    InParanoidi O04486.
    KOi K07904.
    OMAi AKKPCCS.
    PhylomeDBi O04486.

    Gene expression databases

    Genevestigatori O04486.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Bischoff F., Palme K.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Analysis of the small GTPase gene superfamily of Arabidopsis."
      Vernoud V., Horton A.C., Yang Z., Nielsen E.
      Plant Physiol. 131:1191-1208(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    7. "Rab-A2 and Rab-A3 GTPases define a trans-Golgi endosomal membrane domain in Arabidopsis that contributes substantially to the cell plate."
      Chow C.M., Neto H., Foucart C., Moore I.
      Plant Cell 20:101-123(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRAA2A_ARATH
    AccessioniPrimary (citable) accession number: O04486
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3