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Protein

Ras-related protein RABA2a

Gene

RABA2A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Intracellular vesicle trafficking and protein transport.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPBy similarity
Nucleotide bindingi67 – 715GTPBy similarity
Nucleotide bindingi125 – 1284GTPBy similarity
Nucleotide bindingi155 – 1562GTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • cytokinesis by cell plate formation Source: TAIR
  • intracellular protein transport Source: GO_Central
  • metabolic process Source: GOC
  • Rab protein signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_358548. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein RABA2a
Short name:
AtRABA2a
Alternative name(s):
Ras-related protein Rab11C
Short name:
AtRab11C
Gene namesi
Name:RABA2A
Synonyms:RAB11C
Ordered Locus Names:At1g09630
ORF Names:F21M12.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G09630.

Subcellular locationi

  • Endosome membrane 1 Publication
  • Golgi apparatustrans-Golgi network membrane 1 Publication; Lipid-anchor 1 Publication

  • Note: During cytokinesis located to the growing margins of the cell plate.

GO - Cellular componenti

  • cell plate Source: TAIR
  • cytosol Source: TAIR
  • endosome Source: TAIR
  • endosome membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB-SubCell
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 214213Ras-related protein RABA2aPRO_0000121165Add
BLAST
Propeptidei215 – 2173Removed in mature formSequence AnalysisPRO_0000370754

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi213 – 2131S-palmitoyl cysteineBy similarity
Modified residuei214 – 2141Cysteine methyl esterSequence Analysis
Lipidationi214 – 2141S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiO04486.
PRIDEiO04486.

Expressioni

Tissue specificityi

Expressed in root tips.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi22731. 3 interactions.
IntActiO04486. 4 interactions.
MINTiMINT-7712599.
STRINGi3702.AT1G09630.1.

Structurei

3D structure databases

ProteinModelPortaliO04486.
SMRiO04486. Positions 9-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 499Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
InParanoidiO04486.
KOiK07904.
OMAiMADQSNF.
PhylomeDBiO04486.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O04486-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRPDEEYD YLFKVVLIGD SGVGKSNLLS RFTRNEFCLE SKSTIGVEFA
60 70 80 90 100
TRTLQVEGRT VKAQIWDTAG QERYRAITSA YYRGALGALL VYDVTKPTTF
110 120 130 140 150
ENVSRWLKEL RDHADSNIVI MLIGNKTDLK HLRAVATEDA QSYAEKEGLS
160 170 180 190 200
FIETSALEAL NVEKAFQTIL SEVYRIISKK SISSDQTTAN ANIKEGQTID
210
VAATSESNAK KPCCSSS
Length:217
Mass (Da):24,108
Last modified:July 1, 1997 - v1
Checksum:iD8DBFD3192FD92C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74669 mRNA. Translation: AAB61994.1.
AC000132 Genomic DNA. Translation: AAB60720.1.
CP002684 Genomic DNA. Translation: AEE28471.1.
AY045620 mRNA. Translation: AAK73978.1.
AY133657 mRNA. Translation: AAM91487.1.
AY085684 mRNA. Translation: AAM62903.1.
PIRiA86230.
RefSeqiNP_172434.1. NM_100835.2.
UniGeneiAt.20265.

Genome annotation databases

EnsemblPlantsiAT1G09630.1; AT1G09630.1; AT1G09630.
GeneIDi837490.
KEGGiath:AT1G09630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74669 mRNA. Translation: AAB61994.1.
AC000132 Genomic DNA. Translation: AAB60720.1.
CP002684 Genomic DNA. Translation: AEE28471.1.
AY045620 mRNA. Translation: AAK73978.1.
AY133657 mRNA. Translation: AAM91487.1.
AY085684 mRNA. Translation: AAM62903.1.
PIRiA86230.
RefSeqiNP_172434.1. NM_100835.2.
UniGeneiAt.20265.

3D structure databases

ProteinModelPortaliO04486.
SMRiO04486. Positions 9-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi22731. 3 interactions.
IntActiO04486. 4 interactions.
MINTiMINT-7712599.
STRINGi3702.AT1G09630.1.

Proteomic databases

PaxDbiO04486.
PRIDEiO04486.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G09630.1; AT1G09630.1; AT1G09630.
GeneIDi837490.
KEGGiath:AT1G09630.

Organism-specific databases

TAIRiAT1G09630.

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
InParanoidiO04486.
KOiK07904.
OMAiMADQSNF.
PhylomeDBiO04486.

Enzyme and pathway databases

ReactomeiREACT_358548. VxPx cargo-targeting to cilium.

Miscellaneous databases

PROiO04486.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Bischoff F., Palme K.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Analysis of the small GTPase gene superfamily of Arabidopsis."
    Vernoud V., Horton A.C., Yang Z., Nielsen E.
    Plant Physiol. 131:1191-1208(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  7. "Rab-A2 and Rab-A3 GTPases define a trans-Golgi endosomal membrane domain in Arabidopsis that contributes substantially to the cell plate."
    Chow C.M., Neto H., Foucart C., Moore I.
    Plant Cell 20:101-123(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiRAA2A_ARATH
AccessioniPrimary (citable) accession number: O04486
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: July 22, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.