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Protein

T-complex protein 1 subunit epsilon

Gene

CCT5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit epsilon1 Publication
Short name:
TCP-1-epsilon1 Publication
Alternative name(s):
CCT-epsilon1 Publication
Chaperonin CCT5Curated
Gene namesi
Name:CCT5Curated
Ordered Locus Names:At1g24510Imported
ORF Names:F21J9.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G24510
TAIRilocus:2024051 AT1G24510

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283501 – 535T-complex protein 1 subunit epsilonAdd BLAST535

Proteomic databases

PaxDbiO04450
PRIDEiO04450

PTM databases

iPTMnetiO04450

Expressioni

Gene expression databases

ExpressionAtlasiO04450 baseline and differential
GenevisibleiO04450 AT

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi24304, 8 interactors
IntActiO04450, 2 interactors
STRINGi3702.AT1G24510.1

Structurei

3D structure databases

ProteinModelPortaliO04450
SMRiO04450
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0357 Eukaryota
COG0459 LUCA
HOGENOMiHOG000226735
InParanoidiO04450
KOiK09497
OMAiYATDEYG
OrthoDBiEOG093606MU
PhylomeDBiO04450

Family and domain databases

CDDicd03339 TCP1_epsilon, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012718 Chap_CCT_epsi
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF178 PTHR11353:SF178, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02343 chap_CCT_epsi, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O04450-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALAFDEFGR PFIILREQDQ KTRLRGIDAQ KANIAAGKAV ARILRSSLGP
60 70 80 90 100
KGMDKMLQGP DGDITITNDG ATILEQMDVD NQIAKLMVEL SRSQDYEIGD
110 120 130 140 150
GTTGVVVMAG ALLEQAERQL DRGIHPIRIA EGYEMASRVA VEHLERIAQK
160 170 180 190 200
FEFDVNNYEP LVQTCMTTLS SKIVNRCKRS LAEIAVKAVL AVADLERRDV
210 220 230 240 250
NLDLIKVEGK VGGKLEDTEL IYGILIDKDM SHPQMPKQIE DAHIAILTCP
260 270 280 290 300
FEPPKPKTKH KVDIDTVEKF ETLRKQEQQY FDEMVQKCKD VGATLVICQW
310 320 330 340 350
GFDDEANHLL MHRNLPAVRW VGGVELELIA IATGGRIVPR FQELTPEKLG
360 370 380 390 400
KAGVVREKSF GTTKERMLYI EHCANSKAVT VFIRGGNKMM IEETKRSIHD
410 420 430 440 450
ALCVARNLIR NKSIVYGGGA AEIACSLAVD AAADKYPGVE QYAIRAFAEA
460 470 480 490 500
LDSVPMALAE NSGLQPIETL SAVKSQQIKE NIPFYGIDCN DVGTNDMREQ
510 520 530
NVFETLIGKQ QQILLATQVV KMILKIDDVI SNSEY
Length:535
Mass (Da):59,384
Last modified:July 1, 1997 - v1
Checksum:i1CB56343A3AF1DC3
GO
Isoform 2 (identifier: O04450-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available. Derived from EST data.Curated
Show »
Length:459
Mass (Da):51,147
Checksum:i3A515261D0A2B5DF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0573391 – 76Missing in isoform 2. Add BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC000103 Genomic DNA Translation: AAF97977.1
CP002684 Genomic DNA Translation: AEE30541.1
CP002684 Genomic DNA Translation: AEE30542.1
AY075611 mRNA Translation: AAL91625.1
BT000818 mRNA Translation: AAN33193.1
RefSeqiNP_173859.1, NM_102295.6 [O04450-1]
NP_973907.1, NM_202178.3 [O04450-2]
UniGeneiAt.28054
At.41426
At.68082

Genome annotation databases

EnsemblPlantsiAT1G24510.1; AT1G24510.1; AT1G24510 [O04450-1]
AT1G24510.2; AT1G24510.2; AT1G24510 [O04450-2]
GeneIDi839066
GrameneiAT1G24510.1; AT1G24510.1; AT1G24510 [O04450-1]
AT1G24510.2; AT1G24510.2; AT1G24510 [O04450-2]
KEGGiath:AT1G24510

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTCPE_ARATH
AccessioniPrimary (citable) accession number: O04450
Secondary accession number(s): F4IAR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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