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Protein

T-complex protein 1 subunit epsilon

Gene

CCT5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-ATH-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit epsilon1 Publication
Short name:
TCP-1-epsilon1 Publication
Alternative name(s):
CCT-epsilon1 Publication
Chaperonin CCT5Curated
Gene namesi
Name:CCT5Curated
Ordered Locus Names:At1g24510Imported
ORF Names:F21J9.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G24510.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535T-complex protein 1 subunit epsilonPRO_0000128350Add
BLAST

Proteomic databases

PaxDbiO04450.
PRIDEiO04450.

PTM databases

iPTMnetiO04450.

Expressioni

Gene expression databases

ExpressionAtlasiO04450. baseline and differential.
GenevisibleiO04450. AT.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.1 Publication

Protein-protein interaction databases

BioGridi24304. 7 interactions.
IntActiO04450. 2 interactions.
STRINGi3702.AT1G24510.1.

Structurei

3D structure databases

ProteinModelPortaliO04450.
SMRiO04450. Positions 14-529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0357. Eukaryota.
COG0459. LUCA.
HOGENOMiHOG000226735.
InParanoidiO04450.
KOiK09497.
OMAiVDHEIAK.
PhylomeDBiO04450.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012718. Chap_CCT_epsi.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02343. chap_CCT_epsi. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O04450-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALAFDEFGR PFIILREQDQ KTRLRGIDAQ KANIAAGKAV ARILRSSLGP
60 70 80 90 100
KGMDKMLQGP DGDITITNDG ATILEQMDVD NQIAKLMVEL SRSQDYEIGD
110 120 130 140 150
GTTGVVVMAG ALLEQAERQL DRGIHPIRIA EGYEMASRVA VEHLERIAQK
160 170 180 190 200
FEFDVNNYEP LVQTCMTTLS SKIVNRCKRS LAEIAVKAVL AVADLERRDV
210 220 230 240 250
NLDLIKVEGK VGGKLEDTEL IYGILIDKDM SHPQMPKQIE DAHIAILTCP
260 270 280 290 300
FEPPKPKTKH KVDIDTVEKF ETLRKQEQQY FDEMVQKCKD VGATLVICQW
310 320 330 340 350
GFDDEANHLL MHRNLPAVRW VGGVELELIA IATGGRIVPR FQELTPEKLG
360 370 380 390 400
KAGVVREKSF GTTKERMLYI EHCANSKAVT VFIRGGNKMM IEETKRSIHD
410 420 430 440 450
ALCVARNLIR NKSIVYGGGA AEIACSLAVD AAADKYPGVE QYAIRAFAEA
460 470 480 490 500
LDSVPMALAE NSGLQPIETL SAVKSQQIKE NIPFYGIDCN DVGTNDMREQ
510 520 530
NVFETLIGKQ QQILLATQVV KMILKIDDVI SNSEY
Length:535
Mass (Da):59,384
Last modified:July 1, 1997 - v1
Checksum:i1CB56343A3AF1DC3
GO
Isoform 2 (identifier: O04450-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available. Derived from EST data.Curated
Show »
Length:459
Mass (Da):51,147
Checksum:i3A515261D0A2B5DF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7676Missing in isoform 2. VSP_057339Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC000103 Genomic DNA. Translation: AAF97977.1.
CP002684 Genomic DNA. Translation: AEE30541.1.
CP002684 Genomic DNA. Translation: AEE30542.1.
AY075611 mRNA. Translation: AAL91625.1.
BT000818 mRNA. Translation: AAN33193.1.
RefSeqiNP_173859.1. NM_102295.5. [O04450-1]
NP_973907.1. NM_202178.3. [O04450-2]
UniGeneiAt.28054.
At.41426.
At.68082.

Genome annotation databases

EnsemblPlantsiAT1G24510.1; AT1G24510.1; AT1G24510. [O04450-1]
AT1G24510.2; AT1G24510.2; AT1G24510. [O04450-2]
GeneIDi839066.
KEGGiath:AT1G24510.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC000103 Genomic DNA. Translation: AAF97977.1.
CP002684 Genomic DNA. Translation: AEE30541.1.
CP002684 Genomic DNA. Translation: AEE30542.1.
AY075611 mRNA. Translation: AAL91625.1.
BT000818 mRNA. Translation: AAN33193.1.
RefSeqiNP_173859.1. NM_102295.5. [O04450-1]
NP_973907.1. NM_202178.3. [O04450-2]
UniGeneiAt.28054.
At.41426.
At.68082.

3D structure databases

ProteinModelPortaliO04450.
SMRiO04450. Positions 14-529.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24304. 7 interactions.
IntActiO04450. 2 interactions.
STRINGi3702.AT1G24510.1.

PTM databases

iPTMnetiO04450.

Proteomic databases

PaxDbiO04450.
PRIDEiO04450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G24510.1; AT1G24510.1; AT1G24510. [O04450-1]
AT1G24510.2; AT1G24510.2; AT1G24510. [O04450-2]
GeneIDi839066.
KEGGiath:AT1G24510.

Organism-specific databases

TAIRiAT1G24510.

Phylogenomic databases

eggNOGiKOG0357. Eukaryota.
COG0459. LUCA.
HOGENOMiHOG000226735.
InParanoidiO04450.
KOiK09497.
OMAiVDHEIAK.
PhylomeDBiO04450.

Enzyme and pathway databases

ReactomeiR-ATH-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-ATH-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiO04450.

Gene expression databases

ExpressionAtlasiO04450. baseline and differential.
GenevisibleiO04450. AT.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012718. Chap_CCT_epsi.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02343. chap_CCT_epsi. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  4. "Arabidopsis thaliana type I and II chaperonins."
    Hill J.E., Hemmingsen S.M.
    Cell Stress Chaperones 6:190-200(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE, SUBUNIT.

Entry informationi

Entry nameiTCPE_ARATH
AccessioniPrimary (citable) accession number: O04450
Secondary accession number(s): F4IAR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: June 8, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.