O04403 (NLT22_PARJU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Probable non-specific lipid-transfer protein 2 Short name=LTP 2 Alternative name(s): Allergen Par j II Major pollen allergen Par j 2.0102 Protein P8 Allergen=Par j 2.0102
Organism	Parietaria judaica (Pellitory-of-the-wall) (Parietaria diffusa)
Taxonomic identifier	33127 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Rosales › Urticaceae › Parietaria

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
Allergenic properties	Causes an allergic reaction in human. Binds to IgE and induces histamine release from basophils of Pj-pollen-allergic subjects.
Sequence similarities	Belongs to the plant LTP family.

Ontologies

Keywords
Biological process	Transport
Disease	Allergen
Domain	Signal
Ligand	Lipid-binding
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	lipid transport Inferred from electronic annotation. Source: InterPro
Molecular_function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 133	102	Probable non-specific lipid-transfer protein 2		PRO_0000018399
Amino acid modifications
	Disulfide bond	35 ↔ 83		By similarity
	Disulfide bond	45 ↔ 60		By similarity
	Disulfide bond	61 ↔ 106		By similarity
	Disulfide bond	81 ↔ 121		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O04403 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 50DFBB1F7806AF85	FASTA	133	14,107
	10 20 30 40 50 60 MRTVSMAALV VIAAALAWTS SAELASAPAP GEGPCGKVVH HIMPCLKFVK GEEKEPSKSC 70 80 90 100 110 120 CSGTKKLSEE VKTTEQKREA CKCIVAATKG ISGIKNELVA EVPKKCGITT TLPPITADFD 130 CSKIESTIFR GYY

References

[1]	Duro G., Colombo P., Costa M.A., Izzo V., Porcasi R., di Fiore R., Locorotondo G., Mirisola M.G., Cocchiara R., Geraci D. Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Flower.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X95866 mRNA. Translation: CAA65122.1.
3D structure databases
ProteinModelPortal	O04403.
ModBase	Search...
Protein family/group databases
Allergome	507. Par j 2. 509. Par j 2.0102.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR016140. Bifunc_inhib/LTP/seed_store. IPR000528. Plant_LTP. [Graphical view]
Pfam	PF00234. Tryp_alpha_amyl. 1 hit. [Graphical view]
PRINTS	PR00382. LIPIDTRNSFER.
SMART	SM00499. AAI. 1 hit. [Graphical view]
SUPFAM	SSF47699. Bifunc_inhib/LTP/seed_store. 1 hit.
PROSITE	PS00597. PLANT_LTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NLT22_PARJU

Accession

Primary (citable) accession number: O04403

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	July 1, 1997
Last modified:	March 6, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program