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Protein

Major allergen Dau c 1

Gene
N/A
Organism
Daucus carota (Wild carrot)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen Dau c 1
Alternative name(s):
CR16
Pathogenesis-related protein Gea20
Allergen: Dau c 1
OrganismiDaucus carota (Wild carrot)
Taxonomic identifieri4039 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsApialesApiaceaeApioideaeScandiceaeDaucinaeDaucusDaucus sect. Daucus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei287. Dau c 1.
288. Dau c 1.0101.
289. Dau c 1.0102.
290. Dau c 1.0103.
291. Dau c 1.0104.
292. Dau c 1.0105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001541881 – 154Major allergen Dau c 1Add BLAST154

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 14Combined sources10
Helixi16 – 23Combined sources8
Turni24 – 26Combined sources3
Helixi27 – 34Combined sources8
Turni36 – 38Combined sources3
Beta strandi40 – 49Combined sources10
Beta strandi53 – 57Combined sources5
Beta strandi66 – 75Combined sources10
Turni76 – 79Combined sources4
Beta strandi80 – 88Combined sources9
Helixi89 – 91Combined sources3
Turni92 – 94Combined sources3
Beta strandi95 – 106Combined sources12
Beta strandi112 – 123Combined sources12
Helixi130 – 153Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WQLX-ray2.70A/B/C/D1-154[»]
ProteinModelPortaliO04298.
SMRiO04298.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO04298.

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O04298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAQSHSLEI TSSVSAEKIF SGIVLDVDTV IPKAAPGAYK SVEVKGDGGA
60 70 80 90 100
GTVRIITLPE GSPITSMTVR TDAVNKEALT YDSTVIDGDI LLGFIESIET
110 120 130 140 150
HLVVVPTADG GSITKTTAIF HTKGDAVVPE ENIKFADAQN TALFKAIEAY

LIAN
Length:154
Mass (Da):16,049
Last modified:July 1, 1997 - v1
Checksum:i3C5AB57AE671DE82
GO

Sequence cautioni

The sequence AAB01092 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti36P → T in Dau C 1.2. 1
Natural varianti43E → D in Dau C 1.3 and CR16/Gea20. 1
Natural varianti66S → T in Dau C 1.2. 1
Natural varianti80T → S in Dau C 1.2. 1
Natural varianti93G → E in CR16/Gea20. 1
Natural varianti102L → M in Dau C 1.2 and CR16/Gea20. 1
Natural varianti138A → E in Dau C 1.3. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z84376 mRNA. Translation: CAB06416.1.
Z81361 mRNA. Translation: CAB03715.1.
Z81362 mRNA. Translation: CAB03716.1.
D88388 mRNA. Translation: BAA13604.1.
U47087 mRNA. Translation: AAB01092.1. Different initiation.
PIRiT14322.
T14325.
T14326.
T14356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z84376 mRNA. Translation: CAB06416.1.
Z81361 mRNA. Translation: CAB03715.1.
Z81362 mRNA. Translation: CAB03716.1.
D88388 mRNA. Translation: BAA13604.1.
U47087 mRNA. Translation: AAB01092.1. Different initiation.
PIRiT14322.
T14325.
T14326.
T14356.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WQLX-ray2.70A/B/C/D1-154[»]
ProteinModelPortaliO04298.
SMRiO04298.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei287. Dau c 1.
288. Dau c 1.0101.
289. Dau c 1.0102.
290. Dau c 1.0103.
291. Dau c 1.0104.
292. Dau c 1.0105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO04298.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDAU1_DAUCA
AccessioniPrimary (citable) accession number: O04298
Secondary accession number(s): O04296
, O04297, Q39678, Q96407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.