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Protein

Major allergen Dau c 1

Gene
N/A
Organism
Daucus carota (Wild carrot)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen Dau c 1
Alternative name(s):
CR16
Pathogenesis-related protein Gea20
Allergen: Dau c 1
OrganismiDaucus carota (Wild carrot)
Taxonomic identifieri4039 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsApialesApiaceaeApioideaeScandiceaeDaucinaeDaucus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei287. Dau c 1.
288. Dau c 1.0101.
289. Dau c 1.0102.
290. Dau c 1.0103.
291. Dau c 1.0104.
292. Dau c 1.0105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Major allergen Dau c 1PRO_0000154188Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1
154
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 1410Combined sources
Helixi16 – 238Combined sources
Turni24 – 263Combined sources
Helixi27 – 348Combined sources
Turni36 – 383Combined sources
Beta strandi40 – 4910Combined sources
Beta strandi53 – 575Combined sources
Beta strandi66 – 7510Combined sources
Turni76 – 794Combined sources
Beta strandi80 – 889Combined sources
Helixi89 – 913Combined sources
Turni92 – 943Combined sources
Beta strandi95 – 10612Combined sources
Beta strandi112 – 12312Combined sources
Helixi130 – 15324Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WQLX-ray2.70A/B/C/D1-154[»]
ProteinModelPortaliO04298.
SMRiO04298. Positions 2-154.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO04298.

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O04298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAQSHSLEI TSSVSAEKIF SGIVLDVDTV IPKAAPGAYK SVEVKGDGGA
60 70 80 90 100
GTVRIITLPE GSPITSMTVR TDAVNKEALT YDSTVIDGDI LLGFIESIET
110 120 130 140 150
HLVVVPTADG GSITKTTAIF HTKGDAVVPE ENIKFADAQN TALFKAIEAY

LIAN
Length:154
Mass (Da):16,049
Last modified:July 1, 1997 - v1
Checksum:i3C5AB57AE671DE82
GO

Sequence cautioni

The sequence AAB01092 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361P → T in Dau C 1.2.
Natural varianti43 – 431E → D in Dau C 1.3 and CR16/Gea20.
Natural varianti66 – 661S → T in Dau C 1.2.
Natural varianti80 – 801T → S in Dau C 1.2.
Natural varianti93 – 931G → E in CR16/Gea20.
Natural varianti102 – 1021L → M in Dau C 1.2 and CR16/Gea20.
Natural varianti138 – 1381A → E in Dau C 1.3.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z84376 mRNA. Translation: CAB06416.1.
Z81361 mRNA. Translation: CAB03715.1.
Z81362 mRNA. Translation: CAB03716.1.
D88388 mRNA. Translation: BAA13604.1.
U47087 mRNA. Translation: AAB01092.1. Different initiation.
PIRiT14322.
T14325.
T14326.
T14356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z84376 mRNA. Translation: CAB06416.1.
Z81361 mRNA. Translation: CAB03715.1.
Z81362 mRNA. Translation: CAB03716.1.
D88388 mRNA. Translation: BAA13604.1.
U47087 mRNA. Translation: AAB01092.1. Different initiation.
PIRiT14322.
T14325.
T14326.
T14356.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WQLX-ray2.70A/B/C/D1-154[»]
ProteinModelPortaliO04298.
SMRiO04298. Positions 2-154.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei287. Dau c 1.
288. Dau c 1.0101.
289. Dau c 1.0102.
290. Dau c 1.0103.
291. Dau c 1.0104.
292. Dau c 1.0105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO04298.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDAU1_DAUCA
AccessioniPrimary (citable) accession number: O04298
Secondary accession number(s): O04296
, O04297, Q39678, Q96407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.