Reviewed, UniProtKB/Swiss-Prot O04287 (FKB12_VICFA)

Names and origin

Protein names

Recommended name:
    Peptidyl-prolyl isomerase FKBP12
    EC=5.2.1.8
Alternative name(s):
    12 kDa FK506-binding protein
      Short name=12 kDa FKBP
    FKBP-12
    Immunophilin FKBP12
    Peptidyl-prolyl cis-trans isomerase
      Short name=PPIase
      Short name=Rotamase

Gene names

Name:

FKBP12

Organism

Vicia faba (Broad bean)

Taxonomic identifier

3906 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Fabales › Fabaceae › Papilionoideae › Fabeae › Vicia

Protein attributes

Sequence length	112 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit structure	Interacts with FK506. Ref.1
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the FKBP-type PPIase family. FKBP1 subfamily. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Isomerase Rotamase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 112	112	Peptidyl-prolyl isomerase FKBP12		PRO_0000075301
Regions
	Domain	19 – 112	94	PPIase FKBP-type
Amino acid modifications
	Disulfide bond	26 ↔ 80		Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O04287-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 7B1311F74FD3DA7B	FASTA	112	12,101
	10 20 30 40 50 60 MGVEKQIIRA GTGPNPSRGQ NVTVHCTGYG KNGDLSQKFW STKDPGQNPF TFKIGQGSVI 70 80 90 100 110 KGWDEGVLGM QLGEVARLRC SPDYAYGAGG FPAWGIQPNS VLEFEIEVLR AQ

References

[1]	"Molecular characterization of a plant FKBP12 that does not mediate action of FK506 and rapamycin." Xu Q., Liang S., Kudla J., Luan S. Plant J. 15:511-519(1998) [PubMed: 9753776] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISULFIDE BOND, INTERACTION WITH FK506.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U96925 mRNA. Translation: AAB57848.1.
PIR	T12197.
3D structure databases
HSSP	HSSP built from PDB template 1KT1 based on UniProtKB Q9XSH5.
ModBase	Search...
Enzyme and pathway databases
BRENDA	5.2.1.8. 30.
Family and domain databases
InterPro	IPR001179. PPIase_FKBP. [Graphical view]
PANTHER	PTHR10516. PPIase_FKBP. 1 hit.
Pfam	PF00254. FKBP_C. 1 hit. [Graphical view]
PROSITE	PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FKB12_VICFA

Accession

Primary (citable) accession number: O04287

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	July 1, 1997
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)