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Protein

FACT complex subunit SSRP1

Gene

SSRP1

Organism
Vicia faba (Broad bean) (Faba vulgaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi558 – 62669HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, DNA replication, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
FACT complex subunit SSRP1
Alternative name(s):
Facilitates chromatin transcription complex subunit SSRP1
Recombination signal sequence recognition protein 1
Gene namesi
Name:SSRP1
OrganismiVicia faba (Broad bean) (Faba vulgaris)
Taxonomic identifieri3906 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaeVicia

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosome By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642FACT complex subunit SSRP1PRO_0000245198Add
BLAST

Interactioni

Subunit structurei

Component of the FACT complex, a stable heterodimer of SPT16 and SSRP1.By similarity

Structurei

3D structure databases

ProteinModelPortaliO04235.
SMRiO04235. Positions 554-625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi458 – 50649Asp-rich (acidic)Add
BLAST
Compositional biasi516 – 55338Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Belongs to the SSRP1 family.Curated
Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR013719. DUF1747.
IPR009071. HMG_box_dom.
IPR011993. PH_dom-like.
IPR000969. SSrcognition.
IPR024954. SSRP1_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF08512. Rtt106. 1 hit.
PF03531. SSrecog. 1 hit.
[Graphical view]
PRINTSiPR00887. SSRCOGNITION.
SMARTiSM00398. HMG. 1 hit.
SM01287. Rtt106. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O04235-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDGHLFNNI TLGXRGGTNP GQIKIYSGGI LWKRQGGGKT IDVDKTDIMG
60 70 80 90 100
VTWMKVPKTN QLGVQIKDGL LYKFTGFRDQ DVVSLTNFFQ NTFGITVEEK
110 120 130 140 150
QLSVTGRNWG EVDLNGNMLA FMVGSKQAFE VSLADVSQTN LQGKNDVILE
160 170 180 190 200
FHVDDTTGAN EKDSLMEMSF HIPSSNTQFV GDENRPSAQV FRDKIMSMAD
210 220 230 240 250
VGVGGEDAVV TFDGIAILTP RGRYSVELHL SFLRLQGQAN DFKIQYSSVV
260 270 280 290 300
RLFLLPKSNQ PHTFVIISLD PPIRKGQTLY PHIVMQFETD TVVDSELAIS
310 320 330 340 350
EDLYNSKYKD KLELSYKGLI HEVFTTVLRG LSGGKVTKPG NFRSCQDGYA
360 370 380 390 400
VKSSLKAEDG ILYPLEKSFF FLPKPPTLIL HEEIDYVEFE RHAAGGSNMH
410 420 430 440 450
YFDLLIRLKS EQEHLFRNIQ RNEYHNLYGF ISSKGLKIMN IADAQQAVGG
460 470 480 490 500
VAKVLENDDD DAVDPHLERI RNEAGGDESD EEDSDFVIDK DDGGSPTDDS
510 520 530 540 550
GADVSDASQS GGETEKPAKK EPKKDLSSKA SSSKKKSKDA DVDGVKKKQK
560 570 580 590 600
KKKDPNAPKR ALSGFMFFSQ MERENLKKTN PGISFTDVGR VLGEKWKNLS
610 620 630 640
AEEKEPYEAK AQADKKRYKD EISGYKNPQP MNVDSGNESD SA
Length:642
Mass (Da):71,358
Last modified:July 1, 1997 - v1
Checksum:i4FD8C2A076BF3ACB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97906 mRNA. Translation: CAA66480.1.
PIRiT12113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97906 mRNA. Translation: CAA66480.1.
PIRiT12113.

3D structure databases

ProteinModelPortaliO04235.
SMRiO04235. Positions 554-625.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR013719. DUF1747.
IPR009071. HMG_box_dom.
IPR011993. PH_dom-like.
IPR000969. SSrcognition.
IPR024954. SSRP1_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF08512. Rtt106. 1 hit.
PF03531. SSrecog. 1 hit.
[Graphical view]
PRINTSiPR00887. SSRCOGNITION.
SMARTiSM00398. HMG. 1 hit.
SM01287. Rtt106. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSRP1_VICFA
AccessioniPrimary (citable) accession number: O04235
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.