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O04220 (CHSY_CHRAE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase
Gene names
Name:CHS
OrganismChrysosplenium americanum (Golden saxifrage)
Taxonomic identifier36749 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeSaxifragalesSaxifragaceaeChrysosplenium

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Chalcone synthase
PRO_0000215966

Sites

Active site1671 By similarity

Sequences

Sequence LengthMass (Da)Tools
O04220 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: A9EEB6CC8FD7722C

FASTA39643,415
        10         20         30         40         50         60 
MSSAALMEEI RNAQRAEGPA TILAIGTATP ANCVIQADYP DFYFRITNSE HKTELKEKFQ 

        70         80         90        100        110        120 
RMCDKSMIKK RYMHLTEDLL KENPKMCEYM APSLDARQDM VVVEIRKLGK EAAVKAIKEW 

       130        140        150        160        170        180 
GQPKSKITHL VFCTTSGVDM PGADYQLTKL LGLRPSVKRL MMYQQGCFPG GTVLRLAKDL 

       190        200        210        220        230        240 
AENNRGARVL VVCSEITAVT FRGPSDTHLD SLVGQALFGD GAAALIVGAD PDTAIERPLF 

       250        260        270        280        290        300 
ELVSAAQTIL PDSDGAIDGH LREVGLTFHL LKDVPGLISK NIEKSLIEAF KPIGINDWNS 

       310        320        330        340        350        360 
IFWIAHPGGP AILDQVEHKL APGRRANSRA TRHILSEYGN MSSACVLFIL DEMRKKSARR 

       370        380        390 
REATTGDGLE WGVLFGFGPG LTVETVVLHS VPAITA 

« Hide

References

[1]"A cDNA encoding chalcone synthase from Chrysosplenium americanum."
Gauthier A., Gulick P.J., Ibrahim R.K.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U96661 mRNA. Translation: AAB54075.1.

3D structure databases

ProteinModelPortalO04220.
SMRO04220. Positions 7-391.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSY_CHRAE
AccessionPrimary (citable) accession number: O04220
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways