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O04220

- CHSY_CHRAE

UniProt

O04220 - CHSY_CHRAE

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Protein

Chalcone synthase

Gene
CHS
Organism
Chrysosplenium americanum (Golden saxifrage)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei167 – 1671 By similarity

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase
Gene namesi
Name:CHS
OrganismiChrysosplenium americanum (Golden saxifrage)
Taxonomic identifieri36749 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeSaxifragalesSaxifragaceaeChrysosplenium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Chalcone synthasePRO_0000215966Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO04220.
SMRiO04220. Positions 7-391.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O04220-1 [UniParc]FASTAAdd to Basket

« Hide

MSSAALMEEI RNAQRAEGPA TILAIGTATP ANCVIQADYP DFYFRITNSE    50
HKTELKEKFQ RMCDKSMIKK RYMHLTEDLL KENPKMCEYM APSLDARQDM 100
VVVEIRKLGK EAAVKAIKEW GQPKSKITHL VFCTTSGVDM PGADYQLTKL 150
LGLRPSVKRL MMYQQGCFPG GTVLRLAKDL AENNRGARVL VVCSEITAVT 200
FRGPSDTHLD SLVGQALFGD GAAALIVGAD PDTAIERPLF ELVSAAQTIL 250
PDSDGAIDGH LREVGLTFHL LKDVPGLISK NIEKSLIEAF KPIGINDWNS 300
IFWIAHPGGP AILDQVEHKL APGRRANSRA TRHILSEYGN MSSACVLFIL 350
DEMRKKSARR REATTGDGLE WGVLFGFGPG LTVETVVLHS VPAITA 396
Length:396
Mass (Da):43,415
Last modified:July 1, 1997 - v1
Checksum:iA9EEB6CC8FD7722C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96661 mRNA. Translation: AAB54075.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96661 mRNA. Translation: AAB54075.1 .

3D structure databases

ProteinModelPortali O04220.
SMRi O04220. Positions 7-391.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A cDNA encoding chalcone synthase from Chrysosplenium americanum."
    Gauthier A., Gulick P.J., Ibrahim R.K.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCHSY_CHRAE
AccessioniPrimary (citable) accession number: O04220
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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