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Protein

Ras-related protein RABG3b

Gene

RABG3B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Intracellular vesicle trafficking and protein transport. Functions in autophagy. Involved in xylem and tracheary element differentiation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTPBy similarity
Nucleotide bindingi63 – 675GTPBy similarity
Nucleotide bindingi125 – 1284GTPBy similarity
Nucleotide bindingi158 – 1592GTPBy similarity

GO - Molecular functioni

  • GTP binding Source: TAIR

GO - Biological processi

  • autophagic cell death Source: TAIR
  • positive regulation of autophagy Source: UniProtKB
  • programmed cell death involved in cell development Source: TAIR
  • protein transport Source: UniProtKB-KW
  • small GTPase mediated signal transduction Source: InterPro
  • tracheary element differentiation Source: TAIR
  • xylem development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein RABG3b
Short name:
AtRABG3b
Alternative name(s):
Ras-related protein Rab75
Short name:
AtRab75
Gene namesi
Name:RABG3B
Synonyms:RAB7, RAB75
Ordered Locus Names:At1g22740
ORF Names:T22J18.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G22740.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: UniProtKB-SubCell
  • vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi22 – 221T → N: Dominant negative (GDP-bound form); inhibits autophagy and tracheary element formation. 1 Publication
Mutagenesisi67 – 671Q → L: Constitutively active (GTP bound form); stimulates autophagy and tracheary element formation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 203202Ras-related protein RABG3bPRO_0000121280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi201 – 2011S-geranylgeranyl cysteineBy similarity
Modified residuei203 – 2031Cysteine methyl esterBy similarity
Lipidationi203 – 2031S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiO04157.
PRIDEiO04157.

Expressioni

Tissue specificityi

Expressed in xylem cells of inflorescence stems.1 Publication

Gene expression databases

GenevisibleiO04157. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G22740.1.

Structurei

3D structure databases

ProteinModelPortaliO04157.
SMRiO04157. Positions 8-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0394. Eukaryota.
ENOG410XNZV. LUCA.
HOGENOMiHOG000233968.
InParanoidiO04157.
KOiK07897.
OMAiPPDPKTF.
OrthoDBiEOG09360LTD.
PhylomeDBiO04157.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O04157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTRRRTLLK VIILGDSGVG KTSLMNQYVN NKFSQQYKAT IGADFVTKEL
60 70 80 90 100
QIDDRLVTLQ IWDTAGQERF QSLGVAFYRG ADCCVLVYDV NHLKSFESLD
110 120 130 140 150
NWHNEFLTRA SPRDPMAFPF ILLGNKVDID GGNSRVVSEK KAREWCAEKG
160 170 180 190 200
NIVYFETSAK EDYNVDDSFL CITKLALANE RDQDIYFQPD TGSVPEQRGG

CAC
Length:203
Mass (Da):22,945
Last modified:July 1, 1997 - v1
Checksum:i18FAA93B2709C14A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071850 mRNA. Translation: BAB68375.1.
Y09821 mRNA. Translation: CAA70951.1.
Y12227 Genomic DNA. Translation: CAA72904.1.
AC003979 Genomic DNA. Translation: AAC25512.1.
CP002684 Genomic DNA. Translation: AEE30279.1.
BT024589 mRNA. Translation: ABD42987.1.
PIRiT00770.
RefSeqiNP_173688.1. NM_102121.2.
UniGeneiAt.20067.

Genome annotation databases

EnsemblPlantsiAT1G22740.1; AT1G22740.1; AT1G22740.
GeneIDi838880.
GrameneiAT1G22740.1; AT1G22740.1; AT1G22740.
KEGGiath:AT1G22740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071850 mRNA. Translation: BAB68375.1.
Y09821 mRNA. Translation: CAA70951.1.
Y12227 Genomic DNA. Translation: CAA72904.1.
AC003979 Genomic DNA. Translation: AAC25512.1.
CP002684 Genomic DNA. Translation: AEE30279.1.
BT024589 mRNA. Translation: ABD42987.1.
PIRiT00770.
RefSeqiNP_173688.1. NM_102121.2.
UniGeneiAt.20067.

3D structure databases

ProteinModelPortaliO04157.
SMRiO04157. Positions 8-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G22740.1.

Proteomic databases

PaxDbiO04157.
PRIDEiO04157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G22740.1; AT1G22740.1; AT1G22740.
GeneIDi838880.
GrameneiAT1G22740.1; AT1G22740.1; AT1G22740.
KEGGiath:AT1G22740.

Organism-specific databases

TAIRiAT1G22740.

Phylogenomic databases

eggNOGiKOG0394. Eukaryota.
ENOG410XNZV. LUCA.
HOGENOMiHOG000233968.
InParanoidiO04157.
KOiK07897.
OMAiPPDPKTF.
OrthoDBiEOG09360LTD.
PhylomeDBiO04157.

Miscellaneous databases

PROiO04157.

Gene expression databases

GenevisibleiO04157. AT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAG3B_ARATH
AccessioniPrimary (citable) accession number: O04157
Secondary accession number(s): Q2HIJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Plants silencing RABG3B display a significant decrease in the number of both protoxylem and metaxylem cells in the basal region of inflorescence stems.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.