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O04111 (CHSY_PERFR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase
Gene names
Name:CHS
OrganismPerilla frutescens (Beefsteak mint) (Perilla ocymoides)
Taxonomic identifier48386 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesLamiaceaeNepetoideaeElsholtzieaePerilla

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Chalcone synthase
PRO_0000216027

Sites

Active site1641 By similarity

Sequences

Sequence LengthMass (Da)Tools
O04111 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: AE071BE50845242E

FASTA39142,686
        10         20         30         40         50         60 
MVTVEDIRRA QRAEGPATVM AIGTATPENC VDQSTYPDYY FRITNSEHRT DLKEKFKRMC 

        70         80         90        100        110        120 
EKSMIRKRYM HLTEEFLKEN PNMTAYMAPS LDARQDIVVV EVPKLGKEAA QKAIKEWGQP 

       130        140        150        160        170        180 
KSKITHLVFC TTSGVDMPGA DYQLTKLLGL RPSVKRFMMY QQGCFAGGTV LRMAKDLAEN 

       190        200        210        220        230        240 
NAGARVLVVC SEITAVTFRG PSESHLDSLV GQALFGDGAA AVIVGSDPVV GVERPLFQLV 

       250        260        270        280        290        300 
SAAQTILPDS DGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLKEAFGPL GISDWNSVFW 

       310        320        330        340        350        360 
IAHPGGPAIL DQVEAKLGLK PEKLRSTRHV LGEYGNMSSA CVLFILDEMR KSSAKEGMSS 

       370        380        390 
TGEGLDWGVL FGFGPGLTVE TVVLHSVPIN N 

« Hide

References

[1]"Cloning and molecular analysis of structural genes involved in anthocyanin biosynthesis and expressed in a forma-specific manner in Perilla frutescens."
Gong Z., Yamazaki M., Sugiyama M., Tanaka Y., Saito K.
Plant Mol. Biol. 35:915-927(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB002815 mRNA. Translation: BAA19656.1.

3D structure databases

ProteinModelPortalO04111.
SMRO04111. Positions 3-389.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSY_PERFR
AccessionPrimary (citable) accession number: O04111
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways