Reviewed, UniProtKB/Swiss-Prot O04016 (P5CR_ACTCH)

Names and origin

Protein names	Recommended name:     Pyrroline-5-carboxylate reductase       Short name=P5C reductase       Short name=P5CR     EC=1.5.1.2
Organism	Actinidia chinensis (Kiwi) (Yangtao)
Taxonomic identifier	3625 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › Ericales › Actinidiaceae › Actinidia

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Pyrroline-5-carboxylate reductase		PRO_0000187322

Sequences

	Sequence		Length	Mass (Da)
	O04016-1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 198B6E934F190236	FASTA	278	29,004
	10 20 30 40 50 60 MAAAAFVPIP TDTYKLGFIG AGKMAESIAR GVVKSGVLPA SRIRTAHLGS ARREAFESFG 70 80 90 100 110 120 VKVLDRNDQV VEDSDVIIFS VKPQIVKEVV LQLRPLLSEK QLLVSIVAGV KLKELEDWAG 130 140 150 160 170 180 HSRFIRVMPN TPAAVGEAAS VMSLGATATG EDGELITKLF GAIGKIWKAD EKLFDAVTGL 190 200 210 220 230 240 SGSGPAYIFL AIEALADGGV AAGLPRELAL GLASQTVLGA ASMVARGGKH PGQLKDDVAS 250 260 270 AGGTTIAGIH ELEKGGFRGT LMNAVVSATK RSQEIFKR

References

[1]	Walton E.F., Podivinsky E., Wu R.M., Reynolds P.H.S., Young L.W. Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Axillary bud.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U92287 mRNA. Translation: AAC14482.1.
3D structure databases
SMR	O04016. Positions 13-276.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.5.1.2. 67098.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_ACTCH

Accession

Primary (citable) accession number: O04016

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 1, 1997
Last modified:	February 9, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)