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Protein

1-Cys peroxiredoxin PER1

Gene

PER1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Antioxidant protein that seems to contribute to the inhibition of germination during stress.1 Publication

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei46 – 461By similarity

GO - Molecular functioni

  • thioredoxin peroxidase activity Source: TAIR

GO - Biological processi

  • maintenance of seed dormancy Source: TAIR
  • response to desiccation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciARA:AT1G48130-MONOMER.

Protein family/group databases

PeroxiBasei4362. At1CysPrx.

Names & Taxonomyi

Protein namesi
Recommended name:
1-Cys peroxiredoxin PER1 (EC:1.11.1.15)
Alternative name(s):
Rehydrin homolog
Thioredoxin peroxidase
Gene namesi
Name:PER1
Ordered Locus Names:At1g48130
ORF Names:F21D18.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G48130.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2162161-Cys peroxiredoxin PER1PRO_0000135107Add
BLAST

Proteomic databases

PaxDbiO04005.
PRIDEiO04005.

Expressioni

Tissue specificityi

Predominantly expressed in seed. Expressed in endosperm, embryo and aleurone cells. Also detected in young seedlings, abscission zones, stem branching points.2 Publications

Developmental stagei

Expressed during the late globular stage and late torpedo stage of the embryo, and in distinct cells of unfertilized and fertilized ovules.1 Publication

Inductioni

By abscisic acid (ABA) and oxidative stress.1 Publication

Gene expression databases

GenevisibleiO04005. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G48130.1.

Structurei

3D structure databases

ProteinModelPortaliO04005.
SMRiO04005. Positions 3-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 159156ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi191 – 21424Bipartite nuclear localization signalSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the AhpC/TSA family. Rehydrin subfamily.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0854. Eukaryota.
COG0450. LUCA.
HOGENOMiHOG000022346.
KOiK11188.
OMAiIDSNPSH.
PhylomeDBiO04005.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O04005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGITLGDTV PNLEVETTHD KFKLHDYFAN SWTVLFSHPG DFTPVCTTEL
60 70 80 90 100
GAMAKYAHEF DKRGVKLLGL SCDDVQSHKD WIKDIEAFNH GSKVNYPIIA
110 120 130 140 150
DPNKEIIPQL NMIDPIENGP SRALHIVGPD SKIKLSFLYP STTGRNMDEV
160 170 180 190 200
LRALDSLLMA SKHNNKIATP VNWKPDQPVV ISPAVSDEEA KKMFPQGFKT
210
ADLPSKKGYL RHTEVS
Length:216
Mass (Da):24,081
Last modified:July 1, 1997 - v1
Checksum:i60B8ADE9EC8632FB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231K → T in CAA85539 (Ref. 6) Curated
Sequence conflicti77 – 771S → T in CAA85539 (Ref. 6) Curated
Sequence conflicti107 – 1071I → N in CAA85539 (Ref. 6) Curated
Sequence conflicti212 – 2121H → R in AAT41856 (PubMed:14593172).Curated
Sequence conflicti212 – 2121H → R in AAO41963 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12089 Genomic DNA. Translation: CAA72804.1.
AC023673 Genomic DNA. Translation: AAF79536.1.
CP002684 Genomic DNA. Translation: AEE32252.1.
BT003916 mRNA. Translation: AAO41963.1.
BT014873 mRNA. Translation: AAT41856.1.
Z37278 mRNA. Translation: CAA85539.1.
RefSeqiNP_175247.1. NM_103709.3.
UniGeneiAt.38476.

Genome annotation databases

EnsemblPlantsiAT1G48130.1; AT1G48130.1; AT1G48130.
GeneIDi841231.
GrameneiAT1G48130.1; AT1G48130.1; AT1G48130.
KEGGiath:AT1G48130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12089 Genomic DNA. Translation: CAA72804.1.
AC023673 Genomic DNA. Translation: AAF79536.1.
CP002684 Genomic DNA. Translation: AEE32252.1.
BT003916 mRNA. Translation: AAO41963.1.
BT014873 mRNA. Translation: AAT41856.1.
Z37278 mRNA. Translation: CAA85539.1.
RefSeqiNP_175247.1. NM_103709.3.
UniGeneiAt.38476.

3D structure databases

ProteinModelPortaliO04005.
SMRiO04005. Positions 3-213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G48130.1.

Protein family/group databases

PeroxiBasei4362. At1CysPrx.

Proteomic databases

PaxDbiO04005.
PRIDEiO04005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G48130.1; AT1G48130.1; AT1G48130.
GeneIDi841231.
GrameneiAT1G48130.1; AT1G48130.1; AT1G48130.
KEGGiath:AT1G48130.

Organism-specific databases

TAIRiAT1G48130.

Phylogenomic databases

eggNOGiKOG0854. Eukaryota.
COG0450. LUCA.
HOGENOMiHOG000022346.
KOiK11188.
OMAiIDSNPSH.
PhylomeDBiO04005.

Enzyme and pathway databases

BioCyciARA:AT1G48130-MONOMER.

Miscellaneous databases

PROiO04005.

Gene expression databases

GenevisibleiO04005. AT.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The expression of a peroxiredoxin antioxidant gene, AtPer1, in Arabidopsis thaliana is seed-specific and related to dormancy."
    Haslekas C., Stacy R.A.P., Nygaard V., Culianez-Macia F.A., Aalen R.B.
    Plant Mol. Biol. 36:833-845(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Arabidopsis ORF clones."
    Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "The Arabidopsis thaliana transcribed genome: the GDR cDNA program."
    Raynal M., Grellet F., Laudie M., Meyer Y., Cooke R., Delseny M.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-115.
    Strain: cv. Columbia.
    Tissue: Green siliques.
  7. "ABI3 mediates expression of the peroxiredoxin antioxidant AtPER1 gene and induction by oxidative stress."
    Haslekas C., Grini P.E., Nordgard S.H., Thorstensen T., Viken M.K., Nygaard V., Aalen R.B.
    Plant Mol. Biol. 53:313-326(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  8. "Seed 1-cysteine peroxiredoxin antioxidants are not involved in dormancy, but contribute to inhibition of germination during stress."
    Haslekas C., Viken M.K., Grini P.E., Nygaard V., Nordgard S.H., Meza T.J., Aalen R.B.
    Plant Physiol. 133:1148-1157(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  9. "The plant multigenic family of thiol peroxidases."
    Rouhier N., Jacquot J.-P.
    Free Radic. Biol. Med. 38:1413-1421(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.

Entry informationi

Entry nameiREHY_ARATH
AccessioniPrimary (citable) accession number: O04005
Secondary accession number(s): Q42319, Q84WE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.