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O04004 (NLTP6_AMBAR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-specific lipid-transfer protein

Short name=LTP
Alternative name(s):
Allergen Amb a VI
Allergen Ra6
Pollen allergen Amb a 6
Allergen=Amb a 6
OrganismAmbrosia artemisiifolia (Short ragweed)
Taxonomic identifier4212 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeAmbrosia

Protein attributes

Sequence length118 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues By similarity.

Allergenic properties

Causes an allergic reaction in human. Binds to IgE.

Sequence similarities

Belongs to the plant LTP family.

Ontologies

Keywords
   Biological processTransport
   Coding sequence diversityPolymorphism
   DiseaseAllergen
   DomainSignal
   LigandLipid-binding
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processlipid transport

Inferred from electronic annotation. Source: InterPro

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Ref.2
Chain26 – 11893Non-specific lipid-transfer protein
PRO_0000018360

Amino acid modifications

Disulfide bond30 ↔ 76 By similarity
Disulfide bond40 ↔ 53 By similarity
Disulfide bond54 ↔ 98 By similarity
Disulfide bond74 ↔ 113 By similarity

Natural variations

Natural variant261Missing in Ra6B. Ref.2
Natural variant271S → P in Ra6A. Ref.1 Ref.2
Natural variant321T → A in Ra6B. Ref.2
Natural variant321T → D. Ref.1
Natural variant361I → N in Ra6A. Ref.1 Ref.2
Natural variant671K → P. Ref.1
Natural variant711V → M. Ref.1
Natural variant911M → V. Ref.1
Natural variant1111L → F. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O04004 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 59356E9196C0CD38

FASTA11812,789
        10         20         30         40         50         60 
MDCIRILWSV AVGLLLVSWR PTMFAASPTC DTVQNILAPC AGFLTGQEPS KACCTGVNNL 

        70         80         90        100        110 
NNSRKTKADR VAVCNCIKEL TKSIAYDPKR MPLLSTKCGV KPDFPAVDKN LDCSKLPV 

« Hide

References

[1]"Cloning and expression of ragweed allergen Amb a 6."
Hiller K.M., Lubahn B.C., Klapper D.G.
Scand. J. Immunol. 48:26-36(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANTS PRO-27; ASP-32; ASN-36; PRO-67; MET-71; VAL-91 AND PHE-111.
Tissue: Flower.
[2]"Isolation and properties of a new short ragweed pollen allergen, Ra6."
Roebber M., Hussain R., Klapper D.G., Marsh D.G.
J. Immunol. 131:706-711(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF N-TERMINUS, VARIANTS RA6A PRO-27 AND ASN-36, VARIANTS RA6B ALA-26 DEL AND ALA-32, CHARACTERIZATION.
Tissue: Pollen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U89793 mRNA. Translation: AAB51146.1.

3D structure databases

ProteinModelPortalO04004.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome29. Amb a 6.
3070. Amb a 6.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR016140. Bifunc_inhib/LTP/seed_store.
IPR000528. Plant_LTP.
[Graphical view]
PfamPF00234. Tryp_alpha_amyl. 1 hit.
[Graphical view]
PRINTSPR00382. LIPIDTRNSFER.
SMARTSM00499. AAI. 1 hit.
[Graphical view]
SUPFAMSSF47699. SSF47699. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNLTP6_AMBAR
AccessionPrimary (citable) accession number: O04004
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 1, 1997
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries