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O04004

- NLTP6_AMBAR

UniProt

O04004 - NLTP6_AMBAR

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Protein

Non-specific lipid-transfer protein

Gene
N/A
Organism
Ambrosia artemisiifolia (Short ragweed)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).By similarity

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW

GO - Biological processi

  1. lipid transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific lipid-transfer protein
Short name:
LTP
Alternative name(s):
Allergen Amb a VI
Allergen Ra6
Pollen allergen Amb a 6
Allergen: Amb a 6
OrganismiAmbrosia artemisiifolia (Short ragweed)
Taxonomic identifieri4212 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeAmbrosia

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei29. Amb a 6.
3070. Amb a 6.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 11893Non-specific lipid-transfer proteinPRO_0000018360Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 76By similarity
Disulfide bondi40 ↔ 53By similarity
Disulfide bondi54 ↔ 98By similarity
Disulfide bondi74 ↔ 113By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliO04004.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the plant LTP family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR016140. Bifunc_inhib/LTP/seed_store.
IPR000528. Plant_LTP.
[Graphical view]
PfamiPF00234. Tryp_alpha_amyl. 1 hit.
[Graphical view]
PRINTSiPR00382. LIPIDTRNSFER.
SMARTiSM00499. AAI. 1 hit.
[Graphical view]
SUPFAMiSSF47699. SSF47699. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O04004-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDCIRILWSV AVGLLLVSWR PTMFAASPTC DTVQNILAPC AGFLTGQEPS
60 70 80 90 100
KACCTGVNNL NNSRKTKADR VAVCNCIKEL TKSIAYDPKR MPLLSTKCGV
110
KPDFPAVDKN LDCSKLPV
Length:118
Mass (Da):12,789
Last modified:July 1, 1997 - v1
Checksum:i59356E9196C0CD38
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261Missing in Ra6B. 1 Publication
Natural varianti27 – 271S → P in Ra6A. 2 Publications
Natural varianti32 – 321T → A in Ra6B. 1 Publication
Natural varianti32 – 321T → D.1 Publication
Natural varianti36 – 361I → N in Ra6A. 2 Publications
Natural varianti67 – 671K → P.1 Publication
Natural varianti71 – 711V → M.1 Publication
Natural varianti91 – 911M → V.1 Publication
Natural varianti111 – 1111L → F.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U89793 mRNA. Translation: AAB51146.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U89793 mRNA. Translation: AAB51146.1 .

3D structure databases

ProteinModelPortali O04004.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 29. Amb a 6.
3070. Amb a 6.0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016140. Bifunc_inhib/LTP/seed_store.
IPR000528. Plant_LTP.
[Graphical view ]
Pfami PF00234. Tryp_alpha_amyl. 1 hit.
[Graphical view ]
PRINTSi PR00382. LIPIDTRNSFER.
SMARTi SM00499. AAI. 1 hit.
[Graphical view ]
SUPFAMi SSF47699. SSF47699. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of ragweed allergen Amb a 6."
    Hiller K.M., Lubahn B.C., Klapper D.G.
    Scand. J. Immunol. 48:26-36(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANTS PRO-27; ASP-32; ASN-36; PRO-67; MET-71; VAL-91 AND PHE-111.
    Tissue: Flower.
  2. "Isolation and properties of a new short ragweed pollen allergen, Ra6."
    Roebber M., Hussain R., Klapper D.G., Marsh D.G.
    J. Immunol. 131:706-711(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF N-TERMINUS, VARIANTS RA6A PRO-27 AND ASN-36, VARIANTS RA6B ALA-26 DEL AND ALA-32, CHARACTERIZATION.
    Tissue: Pollen.

Entry informationi

Entry nameiNLTP6_AMBAR
AccessioniPrimary (citable) accession number: O04004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 1, 1997
Last modified: October 1, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3