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Protein

Non-specific lipid-transfer protein

Gene
N/A
Organism
Ambrosia artemisiifolia (Short ragweed)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific lipid-transfer protein
Short name:
LTP
Alternative name(s):
Allergen Amb a VI
Allergen Ra6
Pollen allergen Amb a 6
Allergen: Amb a 6
OrganismiAmbrosia artemisiifolia (Short ragweed)
Taxonomic identifieri4212 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceHeliantheaeAmbrosia

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei29. Amb a 6.
3070. Amb a 6.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001836026 – 118Non-specific lipid-transfer proteinAdd BLAST93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 76By similarity
Disulfide bondi40 ↔ 53By similarity
Disulfide bondi54 ↔ 98By similarity
Disulfide bondi74 ↔ 113By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliO04004.
SMRiO04004.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the plant LTP family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR016140. Bifunc_inhib/LTP/seed_store.
IPR000528. Plant_LTP.
PfamiView protein in Pfam
PF14368. LTP_2. 1 hit.
PRINTSiPR00382. LIPIDTRNSFER.
SMARTiView protein in SMART
SM00499. AAI. 1 hit.
SUPFAMiSSF47699. SSF47699. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O04004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCIRILWSV AVGLLLVSWR PTMFAASPTC DTVQNILAPC AGFLTGQEPS
60 70 80 90 100
KACCTGVNNL NNSRKTKADR VAVCNCIKEL TKSIAYDPKR MPLLSTKCGV
110
KPDFPAVDKN LDCSKLPV
Length:118
Mass (Da):12,789
Last modified:July 1, 1997 - v1
Checksum:i59356E9196C0CD38
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti26Missing in Ra6B. 1 Publication1
Natural varianti27S → P in Ra6A. 2 Publications1
Natural varianti32T → A in Ra6B. 1 Publication1
Natural varianti32T → D1 Publication1
Natural varianti36I → N in Ra6A. 2 Publications1
Natural varianti67K → P1 Publication1
Natural varianti71V → M1 Publication1
Natural varianti91M → V1 Publication1
Natural varianti111L → F1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89793 mRNA. Translation: AAB51146.1.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNLTP6_AMBAR
AccessioniPrimary (citable) accession number: O04004
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 1, 1997
Last modified: June 7, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families