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O03986

- HS904_ARATH

UniProt

O03986 - HS904_ARATH

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Protein

Heat shock protein 90-4

Gene

HSP90-4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Molecular chaperone. Due to its association with certain proteins such as hormone receptors and some classes of kinases, it is implicated in signal transduction and development. Has ATPase activity (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341ATPBy similarity
Binding sitei38 – 381ATPBy similarity
Binding sitei80 – 801ATPBy similarity
Binding sitei93 – 931ATPBy similarity
Binding sitei125 – 1251ATP; via amide nitrogenBy similarity
Binding sitei172 – 1721ATPBy similarity
Binding sitei371 – 3711ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1012ATPBy similarity
Nucleotide bindingi120 – 1256ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: InterPro
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 90-4
Short name:
AtHSP90.4
Alternative name(s):
Heat shock protein 81-4
Short name:
HSP81-4
Gene namesi
Name:HSP90-4
Synonyms:HSP81-4
Ordered Locus Names:At5g56000
ORF Names:MDA7.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G56000.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. apoplast Source: TAIR
  2. cell wall Source: TAIR
  3. chloroplast stroma Source: TAIR
  4. cytosol Source: TAIR
  5. Golgi apparatus Source: TAIR
  6. nucleus Source: TAIR
  7. plasma membrane Source: TAIR
  8. vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 699699Heat shock protein 90-4PRO_0000403651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei219 – 2191PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO03986.

Expressioni

Gene expression databases

GenevestigatoriO03986.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi20942. 6 interactions.
STRINGi3702.AT5G56000.1-P.

Structurei

3D structure databases

ProteinModelPortaliO03986.
SMRiO03986. Positions 3-668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi695 – 6995TPR repeat-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi211 – 27969Glu-richAdd
BLAST
Compositional biasi470 – 55687Lys-richAdd
BLAST

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

HOGENOMiHOG000031988.
InParanoidiO03986.
KOiK04079.
OMAiQIEYIEE.
PhylomeDBiO03986.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O03986-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADAETFAFQ AEINQLLSLI INTFYSNKEI FLRELISNSS DALDKIRFES
60 70 80 90 100
LTDKSKLDGQ PELFIHIIPD KTNNTLTIID SGIGMTKADL VNNLGTIARS
110 120 130 140 150
GTKEFMEALA AGADVSMIGQ FGVGFYSAYL VADKVVVTTK HNDDEQYVWE
160 170 180 190 200
SQAGGSFTVT RDTSGEALGR GTKMILYLKE DQMEYIEERR LKDLVKKHSE
210 220 230 240 250
FISYPISLWI EKTIEKEISD DEEEEEKKDE EGKVEEIDEE KEKEEKKKKK
260 270 280 290 300
IKEVTHEWDL VNKQKPIWMR KPEEINKEEY AAFYKSLSND WEEHLAVKHF
310 320 330 340 350
SVEGQLEFKA ILFVPKRAPF DLFDTKKKPN NIKLYVRRVF IMDNCEDIIP
360 370 380 390 400
DYLGFVKGIV DSEDLPLNIS RETLQQNKIL KVIRKNLVKK CLELFFEIAE
410 420 430 440 450
NKEDYNKFYE AFSKNLKLGI HEDSQNRTKI AELLRYHSTK SGDELTSLKD
460 470 480 490 500
YVTRMKEGQN EIFYITGESK KAVENSPFLE KLKKKGYEVL YMVDAIDEYA
510 520 530 540 550
IGQLKEFEGK KLVSATKEGL KLEETDDEKK KKEELKEKFE GLCKVIKDVL
560 570 580 590 600
GDKVEKVIVS DRVVDSPCCL VTGEYGWTAN MERIMKAQAL KDSNTGGYMS
610 620 630 640 650
SKKTMEINPE NSIMDELRKR AEADKNDKSV KDLVLLLFET ALLTSGFSLD
660 670 680 690
EPNTFGSRIH RMLKLGLSIE EDDAVEADAE MPPLEDDADA EGSKMEEVD
Length:699
Mass (Da):80,141
Last modified:July 1, 1997 - v1
Checksum:i28332C54455E0C3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11828 Genomic DNA. Translation: CAA72514.1.
AB011476 Genomic DNA. Translation: BAB09282.1.
CP002688 Genomic DNA. Translation: AED96708.1.
AK227254 mRNA. Translation: BAE99287.1.
RefSeqiNP_200411.1. NM_124982.2.
UniGeneiAt.45945.
At.47215.

Genome annotation databases

EnsemblPlantsiAT5G56000.1; AT5G56000.1; AT5G56000.
GeneIDi835698.
KEGGiath:AT5G56000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11828 Genomic DNA. Translation: CAA72514.1 .
AB011476 Genomic DNA. Translation: BAB09282.1 .
CP002688 Genomic DNA. Translation: AED96708.1 .
AK227254 mRNA. Translation: BAE99287.1 .
RefSeqi NP_200411.1. NM_124982.2.
UniGenei At.45945.
At.47215.

3D structure databases

ProteinModelPortali O03986.
SMRi O03986. Positions 3-668.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 20942. 6 interactions.
STRINGi 3702.AT5G56000.1-P.

Proteomic databases

PRIDEi O03986.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G56000.1 ; AT5G56000.1 ; AT5G56000 .
GeneIDi 835698.
KEGGi ath:AT5G56000.

Organism-specific databases

TAIRi AT5G56000.

Phylogenomic databases

HOGENOMi HOG000031988.
InParanoidi O03986.
KOi K04079.
OMAi QIEYIEE.
PhylomeDBi O03986.

Gene expression databases

Genevestigatori O03986.

Family and domain databases

Gene3Di 3.30.565.10. 1 hit.
HAMAPi MF_00505. HSP90.
InterProi IPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view ]
PANTHERi PTHR11528. PTHR11528. 1 hit.
Pfami PF00183. HSP90. 1 hit.
[Graphical view ]
PIRSFi PIRSF002583. Hsp90. 1 hit.
PRINTSi PR00775. HEATSHOCK90.
SMARTi SM00387. HATPase_c. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEi PS00298. HSP90. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization of hsp90 gene family in Arabidopsis."
    Milioni D., Hatzopoulos P.
    Plant Mol. Biol. 35:955-961(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Landsberg erecta.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
    Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiHS904_ARATH
AccessioniPrimary (citable) accession number: O03986
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3