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Protein

Heat shock protein 90-4

Gene

HSP90-4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone which stabilizes unfolding protein intermediates and functions as a folding molecular chaperone that assists the non-covalent folding of proteins in an ATP-dependent manner.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34ATPBy similarity1
Binding sitei38ATPBy similarity1
Binding sitei80ATPBy similarity1
Binding sitei85ATPBy similarity1
Binding sitei93ATPBy similarity1
Binding sitei99ATPBy similarity1
Binding sitei172ATPBy similarity1
Binding sitei371ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 101ATPBy similarity2
Nucleotide bindingi120 – 125ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-3371511. HSF1 activation.
R-ATH-3371568. Attenuation phase.
R-ATH-3371571. HSF1-dependent transactivation.
R-ATH-6798695. Neutrophil degranulation.
R-ATH-844456. The NLRP3 inflammasome.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 90-4Curated
Short name:
AtHSP90.4Curated
Short name:
AtHsp90-41 Publication
Alternative name(s):
Heat shock protein 81-4Curated
Short name:
Hsp81-41 Publication
Gene namesi
Name:HSP90-41 Publication
Synonyms:HSP81-41 Publication
Ordered Locus Names:At5g56000
ORF Names:MDA7.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G56000.

Subcellular locationi

GO - Cellular componenti

  • apoplast Source: TAIR
  • cell wall Source: TAIR
  • chloroplast stroma Source: TAIR
  • cytosol Source: TAIR
  • Golgi apparatus Source: TAIR
  • nucleus Source: TAIR
  • plasma membrane Source: TAIR
  • vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004036511 – 699Heat shock protein 90-4Add BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO03986.
PRIDEiO03986.

PTM databases

iPTMnetiO03986.

Expressioni

Gene expression databases

GenevisibleiO03986. AT.

Interactioni

Subunit structurei

Homodimer. Interacts with OEP61, OEP64 and OM64.1 Publication

Protein-protein interaction databases

BioGridi20942. 7 interactors.
STRINGi3702.AT5G56000.1.

Structurei

3D structure databases

ProteinModelPortaliO03986.
SMRiO03986.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi695 – 699TPR repeat-binding5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 279Glu-richAdd BLAST69
Compositional biasi470 – 556Lys-richAdd BLAST87

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
COG0326. LUCA.
HOGENOMiHOG000031988.
InParanoidiO03986.
KOiK04079.
OMAiTHANGIY.
OrthoDBiEOG093604DD.
PhylomeDBiO03986.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O03986-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAETFAFQ AEINQLLSLI INTFYSNKEI FLRELISNSS DALDKIRFES
60 70 80 90 100
LTDKSKLDGQ PELFIHIIPD KTNNTLTIID SGIGMTKADL VNNLGTIARS
110 120 130 140 150
GTKEFMEALA AGADVSMIGQ FGVGFYSAYL VADKVVVTTK HNDDEQYVWE
160 170 180 190 200
SQAGGSFTVT RDTSGEALGR GTKMILYLKE DQMEYIEERR LKDLVKKHSE
210 220 230 240 250
FISYPISLWI EKTIEKEISD DEEEEEKKDE EGKVEEIDEE KEKEEKKKKK
260 270 280 290 300
IKEVTHEWDL VNKQKPIWMR KPEEINKEEY AAFYKSLSND WEEHLAVKHF
310 320 330 340 350
SVEGQLEFKA ILFVPKRAPF DLFDTKKKPN NIKLYVRRVF IMDNCEDIIP
360 370 380 390 400
DYLGFVKGIV DSEDLPLNIS RETLQQNKIL KVIRKNLVKK CLELFFEIAE
410 420 430 440 450
NKEDYNKFYE AFSKNLKLGI HEDSQNRTKI AELLRYHSTK SGDELTSLKD
460 470 480 490 500
YVTRMKEGQN EIFYITGESK KAVENSPFLE KLKKKGYEVL YMVDAIDEYA
510 520 530 540 550
IGQLKEFEGK KLVSATKEGL KLEETDDEKK KKEELKEKFE GLCKVIKDVL
560 570 580 590 600
GDKVEKVIVS DRVVDSPCCL VTGEYGWTAN MERIMKAQAL KDSNTGGYMS
610 620 630 640 650
SKKTMEINPE NSIMDELRKR AEADKNDKSV KDLVLLLFET ALLTSGFSLD
660 670 680 690
EPNTFGSRIH RMLKLGLSIE EDDAVEADAE MPPLEDDADA EGSKMEEVD
Length:699
Mass (Da):80,141
Last modified:July 1, 1997 - v1
Checksum:i28332C54455E0C3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11828 Genomic DNA. Translation: CAA72514.1.
AB011476 Genomic DNA. Translation: BAB09282.1.
CP002688 Genomic DNA. Translation: AED96708.1.
AK227254 mRNA. Translation: BAE99287.1.
RefSeqiNP_200411.1. NM_124982.3.
UniGeneiAt.45945.
At.47215.

Genome annotation databases

EnsemblPlantsiAT5G56000.1; AT5G56000.1; AT5G56000.
GeneIDi835698.
GrameneiAT5G56000.1; AT5G56000.1; AT5G56000.
KEGGiath:AT5G56000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11828 Genomic DNA. Translation: CAA72514.1.
AB011476 Genomic DNA. Translation: BAB09282.1.
CP002688 Genomic DNA. Translation: AED96708.1.
AK227254 mRNA. Translation: BAE99287.1.
RefSeqiNP_200411.1. NM_124982.3.
UniGeneiAt.45945.
At.47215.

3D structure databases

ProteinModelPortaliO03986.
SMRiO03986.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi20942. 7 interactors.
STRINGi3702.AT5G56000.1.

PTM databases

iPTMnetiO03986.

Proteomic databases

PaxDbiO03986.
PRIDEiO03986.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G56000.1; AT5G56000.1; AT5G56000.
GeneIDi835698.
GrameneiAT5G56000.1; AT5G56000.1; AT5G56000.
KEGGiath:AT5G56000.

Organism-specific databases

TAIRiAT5G56000.

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
COG0326. LUCA.
HOGENOMiHOG000031988.
InParanoidiO03986.
KOiK04079.
OMAiTHANGIY.
OrthoDBiEOG093604DD.
PhylomeDBiO03986.

Enzyme and pathway databases

ReactomeiR-ATH-3371511. HSF1 activation.
R-ATH-3371568. Attenuation phase.
R-ATH-3371571. HSF1-dependent transactivation.
R-ATH-6798695. Neutrophil degranulation.
R-ATH-844456. The NLRP3 inflammasome.

Miscellaneous databases

PROiO03986.

Gene expression databases

GenevisibleiO03986. AT.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90. 1 hit.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHS904_ARATH
AccessioniPrimary (citable) accession number: O03986
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.