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O03986

- HS904_ARATH

UniProt

O03986 - HS904_ARATH

Protein

Heat shock protein 90-4

Gene

HSP90-4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Molecular chaperone. Due to its association with certain proteins such as hormone receptors and some classes of kinases, it is implicated in signal transduction and development. Has ATPase activity By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341ATPBy similarity
    Binding sitei38 – 381ATPBy similarity
    Binding sitei80 – 801ATPBy similarity
    Binding sitei93 – 931ATPBy similarity
    Binding sitei125 – 1251ATP; via amide nitrogenBy similarity
    Binding sitei172 – 1721ATPBy similarity
    Binding sitei371 – 3711ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi100 – 1012ATPBy similarity
    Nucleotide bindingi120 – 1256ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: InterPro
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock protein 90-4
    Short name:
    AtHSP90.4
    Alternative name(s):
    Heat shock protein 81-4
    Short name:
    HSP81-4
    Gene namesi
    Name:HSP90-4
    Synonyms:HSP81-4
    Ordered Locus Names:At5g56000
    ORF Names:MDA7.4
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G56000.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. apoplast Source: TAIR
    2. cell wall Source: TAIR
    3. chloroplast stroma Source: TAIR
    4. cytosol Source: TAIR
    5. Golgi apparatus Source: TAIR
    6. nucleus Source: TAIR
    7. plasma membrane Source: TAIR
    8. vacuolar membrane Source: TAIR

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 699699Heat shock protein 90-4PRO_0000403651Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei219 – 2191PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiO03986.

    Expressioni

    Gene expression databases

    GenevestigatoriO03986.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi20942. 6 interactions.
    STRINGi3702.AT5G56000.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliO03986.
    SMRiO03986. Positions 3-668.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi695 – 6995TPR repeat-binding

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi211 – 27969Glu-richAdd
    BLAST
    Compositional biasi470 – 55687Lys-richAdd
    BLAST

    Domaini

    The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

    Sequence similaritiesi

    Belongs to the heat shock protein 90 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000031988.
    InParanoidiO03986.
    KOiK04079.
    OMAiQIEYIEE.
    PhylomeDBiO03986.

    Family and domain databases

    Gene3Di3.30.565.10. 1 hit.
    HAMAPiMF_00505. HSP90.
    InterProiIPR003594. HATPase_ATP-bd.
    IPR019805. Heat_shock_protein_90_CS.
    IPR001404. Hsp90_fam.
    IPR020575. Hsp90_N.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view]
    PANTHERiPTHR11528. PTHR11528. 1 hit.
    PfamiPF00183. HSP90. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002583. Hsp90. 1 hit.
    PRINTSiPR00775. HEATSHOCK90.
    SMARTiSM00387. HATPase_c. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEiPS00298. HSP90. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O03986-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADAETFAFQ AEINQLLSLI INTFYSNKEI FLRELISNSS DALDKIRFES    50
    LTDKSKLDGQ PELFIHIIPD KTNNTLTIID SGIGMTKADL VNNLGTIARS 100
    GTKEFMEALA AGADVSMIGQ FGVGFYSAYL VADKVVVTTK HNDDEQYVWE 150
    SQAGGSFTVT RDTSGEALGR GTKMILYLKE DQMEYIEERR LKDLVKKHSE 200
    FISYPISLWI EKTIEKEISD DEEEEEKKDE EGKVEEIDEE KEKEEKKKKK 250
    IKEVTHEWDL VNKQKPIWMR KPEEINKEEY AAFYKSLSND WEEHLAVKHF 300
    SVEGQLEFKA ILFVPKRAPF DLFDTKKKPN NIKLYVRRVF IMDNCEDIIP 350
    DYLGFVKGIV DSEDLPLNIS RETLQQNKIL KVIRKNLVKK CLELFFEIAE 400
    NKEDYNKFYE AFSKNLKLGI HEDSQNRTKI AELLRYHSTK SGDELTSLKD 450
    YVTRMKEGQN EIFYITGESK KAVENSPFLE KLKKKGYEVL YMVDAIDEYA 500
    IGQLKEFEGK KLVSATKEGL KLEETDDEKK KKEELKEKFE GLCKVIKDVL 550
    GDKVEKVIVS DRVVDSPCCL VTGEYGWTAN MERIMKAQAL KDSNTGGYMS 600
    SKKTMEINPE NSIMDELRKR AEADKNDKSV KDLVLLLFET ALLTSGFSLD 650
    EPNTFGSRIH RMLKLGLSIE EDDAVEADAE MPPLEDDADA EGSKMEEVD 699
    Length:699
    Mass (Da):80,141
    Last modified:July 1, 1997 - v1
    Checksum:i28332C54455E0C3E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11828 Genomic DNA. Translation: CAA72514.1.
    AB011476 Genomic DNA. Translation: BAB09282.1.
    CP002688 Genomic DNA. Translation: AED96708.1.
    AK227254 mRNA. Translation: BAE99287.1.
    RefSeqiNP_200411.1. NM_124982.2.
    UniGeneiAt.45945.
    At.47215.

    Genome annotation databases

    EnsemblPlantsiAT5G56000.1; AT5G56000.1; AT5G56000.
    GeneIDi835698.
    KEGGiath:AT5G56000.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11828 Genomic DNA. Translation: CAA72514.1 .
    AB011476 Genomic DNA. Translation: BAB09282.1 .
    CP002688 Genomic DNA. Translation: AED96708.1 .
    AK227254 mRNA. Translation: BAE99287.1 .
    RefSeqi NP_200411.1. NM_124982.2.
    UniGenei At.45945.
    At.47215.

    3D structure databases

    ProteinModelPortali O03986.
    SMRi O03986. Positions 3-668.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 20942. 6 interactions.
    STRINGi 3702.AT5G56000.1-P.

    Proteomic databases

    PRIDEi O03986.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G56000.1 ; AT5G56000.1 ; AT5G56000 .
    GeneIDi 835698.
    KEGGi ath:AT5G56000.

    Organism-specific databases

    TAIRi AT5G56000.

    Phylogenomic databases

    HOGENOMi HOG000031988.
    InParanoidi O03986.
    KOi K04079.
    OMAi QIEYIEE.
    PhylomeDBi O03986.

    Gene expression databases

    Genevestigatori O03986.

    Family and domain databases

    Gene3Di 3.30.565.10. 1 hit.
    HAMAPi MF_00505. HSP90.
    InterProi IPR003594. HATPase_ATP-bd.
    IPR019805. Heat_shock_protein_90_CS.
    IPR001404. Hsp90_fam.
    IPR020575. Hsp90_N.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view ]
    PANTHERi PTHR11528. PTHR11528. 1 hit.
    Pfami PF00183. HSP90. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002583. Hsp90. 1 hit.
    PRINTSi PR00775. HEATSHOCK90.
    SMARTi SM00387. HATPase_c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEi PS00298. HSP90. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization of hsp90 gene family in Arabidopsis."
      Milioni D., Hatzopoulos P.
      Plant Mol. Biol. 35:955-961(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Landsberg erecta.
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
      Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
      DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiHS904_ARATH
    AccessioniPrimary (citable) accession number: O03986
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3