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Protein

Heat shock protein 90-4

Gene

HSP90-4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone which stabilizes unfolding protein intermediates and functions as a folding molecular chaperone that assists the non-covalent folding of proteins in an ATP-dependent manner.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34ATPBy similarity1
Binding sitei38ATPBy similarity1
Binding sitei80ATPBy similarity1
Binding sitei85ATPBy similarity1
Binding sitei93ATPBy similarity1
Binding sitei99ATPBy similarity1
Binding sitei172ATPBy similarity1
Binding sitei371ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 101ATPBy similarity2
Nucleotide bindingi120 – 125ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-ATH-3371511 HSF1 activation
R-ATH-3371568 Attenuation phase
R-ATH-3371571 HSF1-dependent transactivation
R-ATH-6798695 Neutrophil degranulation
R-ATH-844456 The NLRP3 inflammasome

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 90-4Curated
Short name:
AtHSP90.4Curated
Short name:
AtHsp90-41 Publication
Alternative name(s):
Heat shock protein 81-4Curated
Short name:
Hsp81-41 Publication
Gene namesi
Name:HSP90-41 Publication
Synonyms:HSP81-41 Publication
Ordered Locus Names:At5g56000
ORF Names:MDA7.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G56000
TAIRilocus:2161775 AT5G56000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004036511 – 699Heat shock protein 90-4Add BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO03986
PRIDEiO03986

PTM databases

iPTMnetiO03986

Expressioni

Gene expression databases

ExpressionAtlasiO03986 baseline and differential
GenevisibleiO03986 AT

Interactioni

Subunit structurei

Homodimer. Interacts with OEP61, OEP64 and OM64.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi20942, 7 interactors
STRINGi3702.AT5G56000.1

Structurei

3D structure databases

ProteinModelPortaliO03986
SMRiO03986
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi695 – 699TPR repeat-binding5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 279Glu-richAdd BLAST69
Compositional biasi470 – 556Lys-richAdd BLAST87

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

eggNOGiKOG0019 Eukaryota
COG0326 LUCA
HOGENOMiHOG000031988
InParanoidiO03986
KOiK04079
OMAiVKRHSEF
OrthoDBiEOG093604DD
PhylomeDBiO03986

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit

Sequencei

Sequence statusi: Complete.

O03986-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAETFAFQ AEINQLLSLI INTFYSNKEI FLRELISNSS DALDKIRFES
60 70 80 90 100
LTDKSKLDGQ PELFIHIIPD KTNNTLTIID SGIGMTKADL VNNLGTIARS
110 120 130 140 150
GTKEFMEALA AGADVSMIGQ FGVGFYSAYL VADKVVVTTK HNDDEQYVWE
160 170 180 190 200
SQAGGSFTVT RDTSGEALGR GTKMILYLKE DQMEYIEERR LKDLVKKHSE
210 220 230 240 250
FISYPISLWI EKTIEKEISD DEEEEEKKDE EGKVEEIDEE KEKEEKKKKK
260 270 280 290 300
IKEVTHEWDL VNKQKPIWMR KPEEINKEEY AAFYKSLSND WEEHLAVKHF
310 320 330 340 350
SVEGQLEFKA ILFVPKRAPF DLFDTKKKPN NIKLYVRRVF IMDNCEDIIP
360 370 380 390 400
DYLGFVKGIV DSEDLPLNIS RETLQQNKIL KVIRKNLVKK CLELFFEIAE
410 420 430 440 450
NKEDYNKFYE AFSKNLKLGI HEDSQNRTKI AELLRYHSTK SGDELTSLKD
460 470 480 490 500
YVTRMKEGQN EIFYITGESK KAVENSPFLE KLKKKGYEVL YMVDAIDEYA
510 520 530 540 550
IGQLKEFEGK KLVSATKEGL KLEETDDEKK KKEELKEKFE GLCKVIKDVL
560 570 580 590 600
GDKVEKVIVS DRVVDSPCCL VTGEYGWTAN MERIMKAQAL KDSNTGGYMS
610 620 630 640 650
SKKTMEINPE NSIMDELRKR AEADKNDKSV KDLVLLLFET ALLTSGFSLD
660 670 680 690
EPNTFGSRIH RMLKLGLSIE EDDAVEADAE MPPLEDDADA EGSKMEEVD
Length:699
Mass (Da):80,141
Last modified:July 1, 1997 - v1
Checksum:i28332C54455E0C3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11828 Genomic DNA Translation: CAA72514.1
AB011476 Genomic DNA Translation: BAB09282.1
CP002688 Genomic DNA Translation: AED96708.1
AK227254 mRNA Translation: BAE99287.1
RefSeqiNP_200411.1, NM_124982.3
UniGeneiAt.45945
At.47215

Genome annotation databases

EnsemblPlantsiAT5G56000.1; AT5G56000.1; AT5G56000
GeneIDi835698
GrameneiAT5G56000.1; AT5G56000.1; AT5G56000
KEGGiath:AT5G56000

Similar proteinsi

Entry informationi

Entry nameiHS904_ARATH
AccessioniPrimary (citable) accession number: O03986
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: July 1, 1997
Last modified: April 25, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health