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O03986 (HS904_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat shock protein 90-4

Short name=AtHSP90.4
Alternative name(s):
Heat shock protein 81-4
Short name=HSP81-4
Gene names
Name:HSP90-4
Synonyms:HSP81-4
Ordered Locus Names:At5g56000
ORF Names:MDA7.4
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length699 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Molecular chaperone. Due to its association with certain proteins such as hormone receptors and some classes of kinases, it is implicated in signal transduction and development. Has ATPase activity By similarity. HAMAP-Rule MF_00505

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00505

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00505.

Domain

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins By similarity. HAMAP-Rule MF_00505

Sequence similarities

Belongs to the heat shock protein 90 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 699699Heat shock protein 90-4 HAMAP-Rule MF_00505
PRO_0000403651

Regions

Nucleotide binding100 – 1012ATP By similarity
Nucleotide binding120 – 1256ATP By similarity
Motif695 – 6995TPR repeat-binding HAMAP-Rule MF_00505
Compositional bias211 – 27969Glu-rich HAMAP-Rule MF_00505
Compositional bias470 – 55687Lys-rich HAMAP-Rule MF_00505

Sites

Binding site341ATP By similarity
Binding site381ATP By similarity
Binding site801ATP By similarity
Binding site931ATP By similarity
Binding site1251ATP; via amide nitrogen By similarity
Binding site1721ATP By similarity
Binding site3711ATP By similarity

Amino acid modifications

Modified residue2191Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
O03986 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 28332C54455E0C3E

FASTA69980,141
        10         20         30         40         50         60 
MADAETFAFQ AEINQLLSLI INTFYSNKEI FLRELISNSS DALDKIRFES LTDKSKLDGQ 

        70         80         90        100        110        120 
PELFIHIIPD KTNNTLTIID SGIGMTKADL VNNLGTIARS GTKEFMEALA AGADVSMIGQ 

       130        140        150        160        170        180 
FGVGFYSAYL VADKVVVTTK HNDDEQYVWE SQAGGSFTVT RDTSGEALGR GTKMILYLKE 

       190        200        210        220        230        240 
DQMEYIEERR LKDLVKKHSE FISYPISLWI EKTIEKEISD DEEEEEKKDE EGKVEEIDEE 

       250        260        270        280        290        300 
KEKEEKKKKK IKEVTHEWDL VNKQKPIWMR KPEEINKEEY AAFYKSLSND WEEHLAVKHF 

       310        320        330        340        350        360 
SVEGQLEFKA ILFVPKRAPF DLFDTKKKPN NIKLYVRRVF IMDNCEDIIP DYLGFVKGIV 

       370        380        390        400        410        420 
DSEDLPLNIS RETLQQNKIL KVIRKNLVKK CLELFFEIAE NKEDYNKFYE AFSKNLKLGI 

       430        440        450        460        470        480 
HEDSQNRTKI AELLRYHSTK SGDELTSLKD YVTRMKEGQN EIFYITGESK KAVENSPFLE 

       490        500        510        520        530        540 
KLKKKGYEVL YMVDAIDEYA IGQLKEFEGK KLVSATKEGL KLEETDDEKK KKEELKEKFE 

       550        560        570        580        590        600 
GLCKVIKDVL GDKVEKVIVS DRVVDSPCCL VTGEYGWTAN MERIMKAQAL KDSNTGGYMS 

       610        620        630        640        650        660 
SKKTMEINPE NSIMDELRKR AEADKNDKSV KDLVLLLFET ALLTSGFSLD EPNTFGSRIH 

       670        680        690 
RMLKLGLSIE EDDAVEADAE MPPLEDDADA EGSKMEEVD 

« Hide

References

« Hide 'large scale' references
[1]"Genomic organization of hsp90 gene family in Arabidopsis."
Milioni D., Hatzopoulos P.
Plant Mol. Biol. 35:955-961(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Landsberg erecta.
[2]"Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. expand/collapse author list , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y11828 Genomic DNA. Translation: CAA72514.1.
AB011476 Genomic DNA. Translation: BAB09282.1.
CP002688 Genomic DNA. Translation: AED96708.1.
AK227254 mRNA. Translation: BAE99287.1.
RefSeqNP_200411.1. NM_124982.2.
UniGeneAt.45945.
At.47215.

3D structure databases

ProteinModelPortalO03986.
SMRO03986. Positions 3-668.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid20942. 6 interactions.
STRING3702.AT5G56000.1-P.

Proteomic databases

PRIDEO03986.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G56000.1; AT5G56000.1; AT5G56000.
GeneID835698.
KEGGath:AT5G56000.

Organism-specific databases

TAIRAT5G56000.

Phylogenomic databases

HOGENOMHOG000031988.
InParanoidO03986.
KOK04079.
OMATHEWDLV.
PhylomeDBO03986.
ProtClustDBCLSN2686109.

Gene expression databases

GenevestigatorO03986.

Family and domain databases

Gene3D3.30.565.10. 1 hit.
HAMAPMF_00505. HSP90.
InterProIPR003594. HATPase_ATP-bd.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERPTHR11528. PTHR11528. 1 hit.
PfamPF00183. HSP90. 1 hit.
[Graphical view]
PIRSFPIRSF002583. Hsp90. 1 hit.
PRINTSPR00775. HEATSHOCK90.
SMARTSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEPS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHS904_ARATH
AccessionPrimary (citable) accession number: O03986
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: July 1, 1997
Last modified: March 19, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names