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O03895 (COX2_TINMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded onMitochondrion
OrganismTinamus major (Great tinamou) (Tetrao major)
Taxonomic identifier30468 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Palaeognathae › Tinamiformes › Tinamidae › Tinamus

Protein attributes

Sequence length198 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 198›198Cytochrome c oxidase subunit 2
PRO_0000183704

Regions

Transmembrane‹1 – 15›15Helical; Potential
Topological domain16 – 2914Mitochondrial matrix Potential
Transmembrane30 – 4920Helical; Potential
Topological domain50 – 198149Mitochondrial intermembrane Potential

Sites

Metal binding1281Copper A Probable
Metal binding1631Copper A Probable
Metal binding1671Copper A Probable
Metal binding1711Copper A Probable

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
O03895 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: E655564EED39BA89

FASTA19822,305
        10         20         30         40         50         60 
AICSLVLYLL TLMLMEKLSS NTVDAQEVEL IWTILPAIVL ILLALPSLQI LYMMDEIDEP 

        70         80         90        100        110        120 
DLTLKAIGHQ WYWSYEYTDF KDLSFDSYMI PTPDLPTGYF RLLEVDNRVV IPMESPIRMI 

       130        140        150        160        170        180 
ITAADVLHSW AVPTLGVKTD AIPGRLNQTS FITTRPGIFY GQCSEICGAN HSFMPIVVES 

       190 
TPLPHFESWS SLLSTSSL

« Hide

References

[1]"Phylogenetic relationships of the ratite birds: resolving conflicts between molecular and morphological data sets."
Lee K., Feinstein J., Cracraft J.
(In) Mindell D.P. (eds.); Avian molecular evolution and systematics, pp.1-1, Academic Press, New York (1997)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U76070 Genomic DNA. Translation: AAB61332.1.

3D structure databases

ProteinModelPortalO03895.
SMRO03895. Positions 2-191.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG012727.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. Cupredoxin. 1 hit.
SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_TINMA
AccessionPrimary (citable) accession number: O03895
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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