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O03889 (COX2_APTAU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded onMitochondrion
OrganismApteryx australis (Brown kiwi)
Taxonomic identifier8822 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesPalaeognathaeApterygiformesApterygidaeApteryx

Protein attributes

Sequence length199 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 199›199Cytochrome c oxidase subunit 2
PRO_0000183501

Regions

Transmembrane‹1 – 15›15Helical; Potential
Topological domain16 – 2914Mitochondrial matrix Potential
Transmembrane30 – 4920Helical; Potential
Topological domain50 – 199150Mitochondrial intermembrane Potential

Sites

Metal binding1281Copper A Probable
Metal binding1631Copper A Probable
Metal binding1671Copper A Probable
Metal binding1711Copper A Probable

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
O03889 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 0AE496B02F92ACB1

FASTA19922,374
        10         20         30         40         50         60 
AICSLVLYLL TLMLMEKLSS NSVDAQEVEL VWTILPAIVL ILLALPSLQI LYMMDEIDEP 

        70         80         90        100        110        120 
DLTLKAIGHQ WYWTYEYTDF KDLSFDSYMI PTSELPLGHF RLLEVDHRVV VPMESPIRVI 

       130        140        150        160        170        180 
ITAGDVLHSW AVPTLGVKTD AIPGRLNQTS FITTRPGIFY GQCSEICGAN HSYMPIVVES 

       190 
TPLPHFENWS SLLSTSSSL 

« Hide

References

[1]"Phylogenetic relationships of the ratite birds: resolving conflicts between molecular and morphological data sets."
Lee K., Feinstein J., Cracraft J.
(In) Mindell D.P. (eds.); Avian molecular evolution and systematics, pp.1-1, Academic Press, New York (1997)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U76064 Genomic DNA. Translation: AAB61314.1.

3D structure databases

ProteinModelPortalO03889.
SMRO03889. Positions 2-191.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO03889.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG012727.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_APTAU
AccessionPrimary (citable) accession number: O03889
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families