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Protein

Cytochrome c oxidase subunit 2

Gene

MT-CO2

Organism
Apteryx australis (Southern brown kiwi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi128Copper ACurated1
Metal bindingi163Copper ACurated1
Metal bindingi167Copper ACurated1
Metal bindingi171Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded oniMitochondrion
OrganismiApteryx australis (Southern brown kiwi)
Taxonomic identifieri8822 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesPalaeognathaeApterygiformesApterygidaeApteryx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei‹1 – 15HelicalSequence analysisAdd BLAST›15
Topological domaini16 – 29Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei30 – 49HelicalSequence analysisAdd BLAST20
Topological domaini50 – 199Mitochondrial intermembraneSequence analysisAdd BLAST150

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000183501‹1 – 199Cytochrome c oxidase subunit 2Add BLAST›199

Proteomic databases

PRIDEiO03889

Structurei

3D structure databases

ProteinModelPortaliO03889
SMRiO03889
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012727

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Fragment.

O03889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AICSLVLYLL TLMLMEKLSS NSVDAQEVEL VWTILPAIVL ILLALPSLQI
60 70 80 90 100
LYMMDEIDEP DLTLKAIGHQ WYWTYEYTDF KDLSFDSYMI PTSELPLGHF
110 120 130 140 150
RLLEVDHRVV VPMESPIRVI ITAGDVLHSW AVPTLGVKTD AIPGRLNQTS
160 170 180 190
FITTRPGIFY GQCSEICGAN HSYMPIVVES TPLPHFENWS SLLSTSSSL
Length:199
Mass (Da):22,374
Last modified:July 1, 1997 - v1
Checksum:i0AE496B02F92ACB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76064 Genomic DNA Translation: AAB61314.1

Similar proteinsi

Entry informationi

Entry nameiCOX2_APTAU
AccessioniPrimary (citable) accession number: O03889
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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