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O03848

- COX2_LATCH

UniProt

O03848 - COX2_LATCH

Protein

Cytochrome c oxidase subunit 2

Gene

MT-CO2

Organism
Latimeria chalumnae (West Indian ocean coelacanth)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi161 – 1611Copper ACurated
    Metal bindingi196 – 1961Copper ACurated
    Metal bindingi200 – 2001Copper ACurated
    Metal bindingi204 – 2041Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:MT-CO2
    Synonyms:COII, COXII, MTCO2
    Encoded oniMitochondrion
    OrganismiLatimeria chalumnae (West Indian ocean coelacanth)
    Taxonomic identifieri7897 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
    ProteomesiUP000008672: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 231231Cytochrome c oxidase subunit 2PRO_0000183615Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO03848.
    SMRiO03848. Positions 1-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini83 – 231149Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4822HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8220HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00390000017410.
    HOVERGENiHBG012727.
    KOiK02261.
    OrthoDBiEOG7TJ3JX.
    TreeFamiTF344269.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O03848-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHPSQLGLQ DAASPVMEEL LHFHDHALMI VFLISTLVFY IILAMMTTKM    50
    TDKYILDAQE IEIVWTLLPA IVLILVALPS LRILYLIDEV ENPHLTIKAM 100
    GHQWYWSYEY TDYEELSFDS YMTPLQDLNP GQFRLLETDH RMVIPMESLI 150
    RVLISAEDVL HSWAVPALGV KMDAVPGRLN QITFMISRPG LYYGQCSEIC 200
    GANHSFMPIV LEAIPLDPFE DWSSSMLEEA X 231
    Length:231
    Mass (Da):26,399
    Last modified:July 1, 1997 - v1
    Checksum:i70FEE6EC09C47FA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82228 Genomic DNA. Translation: AAC60321.1.
    PIRiD58892.
    RefSeqiNP_008332.1. NC_001804.1.

    Genome annotation databases

    EnsembliENSLACT00000024858; ENSLACP00000021808; ENSLACG00000022074.
    GeneIDi808086.
    KEGGilcm:808086.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82228 Genomic DNA. Translation: AAC60321.1 .
    PIRi D58892.
    RefSeqi NP_008332.1. NC_001804.1.

    3D structure databases

    ProteinModelPortali O03848.
    SMRi O03848. Positions 1-227.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSLACT00000024858 ; ENSLACP00000021808 ; ENSLACG00000022074 .
    GeneIDi 808086.
    KEGGi lcm:808086.

    Organism-specific databases

    CTDi 4513.

    Phylogenomic databases

    GeneTreei ENSGT00390000017410.
    HOVERGENi HBG012727.
    KOi K02261.
    OrthoDBi EOG7TJ3JX.
    TreeFami TF344269.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the mitochondrial genome of a 'living fossil,' the coelacanth (Latimeria chalumnae)."
      Zardoya R., Meyer A.
      Genetics 146:995-1010(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCOX2_LATCH
    AccessioniPrimary (citable) accession number: O03848
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3