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O03848

- COX2_LATCH

UniProt

O03848 - COX2_LATCH

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Protein
Cytochrome c oxidase subunit 2
Gene
MT-CO2, COII, COXII, MTCO2
Organism
Latimeria chalumnae (West Indian ocean coelacanth)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper A Inferred
Metal bindingi196 – 1961Copper A Inferred
Metal bindingi200 – 2001Copper A Inferred
Metal bindingi204 – 2041Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded oniMitochondrion
OrganismiLatimeria chalumnae (West Indian ocean coelacanth)
Taxonomic identifieri7897 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
ProteomesiUP000008672: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei27 – 4822Helical; Reviewed prediction
Add
BLAST
Topological domaini49 – 6214Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei63 – 8220Helical; Reviewed prediction
Add
BLAST
Topological domaini83 – 231149Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Cytochrome c oxidase subunit 2
PRO_0000183615Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO03848.
SMRiO03848. Positions 1-227.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017410.
HOVERGENiHBG012727.
KOiK02261.
OrthoDBiEOG7TJ3JX.
TreeFamiTF344269.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O03848-1 [UniParc]FASTAAdd to Basket

« Hide

MAHPSQLGLQ DAASPVMEEL LHFHDHALMI VFLISTLVFY IILAMMTTKM    50
TDKYILDAQE IEIVWTLLPA IVLILVALPS LRILYLIDEV ENPHLTIKAM 100
GHQWYWSYEY TDYEELSFDS YMTPLQDLNP GQFRLLETDH RMVIPMESLI 150
RVLISAEDVL HSWAVPALGV KMDAVPGRLN QITFMISRPG LYYGQCSEIC 200
GANHSFMPIV LEAIPLDPFE DWSSSMLEEA X 231
Length:231
Mass (Da):26,399
Last modified:July 1, 1997 - v1
Checksum:i70FEE6EC09C47FA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82228 Genomic DNA. Translation: AAC60321.1.
PIRiD58892.
RefSeqiNP_008332.1. NC_001804.1.

Genome annotation databases

EnsembliENSLACT00000024858; ENSLACP00000021808; ENSLACG00000022074.
GeneIDi808086.
KEGGilcm:808086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82228 Genomic DNA. Translation: AAC60321.1 .
PIRi D58892.
RefSeqi NP_008332.1. NC_001804.1.

3D structure databases

ProteinModelPortali O03848.
SMRi O03848. Positions 1-227.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSLACT00000024858 ; ENSLACP00000021808 ; ENSLACG00000022074 .
GeneIDi 808086.
KEGGi lcm:808086.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

GeneTreei ENSGT00390000017410.
HOVERGENi HBG012727.
KOi K02261.
OrthoDBi EOG7TJ3JX.
TreeFami TF344269.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the mitochondrial genome of a 'living fossil,' the coelacanth (Latimeria chalumnae)."
    Zardoya R., Meyer A.
    Genetics 146:995-1010(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCOX2_LATCH
AccessioniPrimary (citable) accession number: O03848
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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