Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O03204

- NU4M_CERSI

UniProt

O03204 - NU4M_CERSI

Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Ceratotherium simum (White rhinoceros) (Square-lipped rhinoceros)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
    Alternative name(s):
    NADH dehydrogenase subunit 4
    Gene namesi
    Name:MT-ND4
    Synonyms:MTND4, NADH4, ND4
    Encoded oniMitochondrion
    OrganismiCeratotherium simum (White rhinoceros) (Square-lipped rhinoceros)
    Taxonomic identifieri9807 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaRhinocerotidaeCeratotherium

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 459459NADH-ubiquinone oxidoreductase chain 4PRO_0000117919Add
    BLAST

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei95 – 11218HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei284 – 30320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 33023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei391 – 41121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei436 – 45621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 4 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG093667.

    Family and domain databases

    InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view]
    PRINTSiPR01437. NUOXDRDTASE4.
    TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O03204-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKIIIPTLM LIPLTWLSKN SMIWINTTAY SLLISFISLP LLSQFNENSL    50
    NMSLTFFSDP LSAPLLVLTT WLLPLMIMAS QHHLSKEPLA RKKLYITMLI 100
    TLQTFLIMTF TATELIFFYI LFEATLIPTL IIITRWGNQT ERLNAGFYFL 150
    FYTLTGSLPL LIALTHIQNL TGSLNLLLIQ YSTQTLPSSW SNAFLWLACM 200
    MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAILLKLGG YGMLRITMIL 250
    NPLTSYMAYP FLMLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA 300
    VLIQTPWSYM GATALMIAHG LTSSVLFCLA NSNYERTHSR TMILARGLQT 350
    LLPLMAMWWL LASLTNLALP PTINLVGELF VVMSSFSWSN ITIILMGTNI 400
    IITALYSLYM LITTQRGKYT HHINNIKPSF TRENTLMALH LLPLLLLSLN 450
    PKIILGTLY 459
    Length:459
    Mass (Da):51,719
    Last modified:July 1, 1997 - v1
    Checksum:iF25C961D11EC5DFE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07726 Genomic DNA. Translation: CAA69015.1.
    RefSeqiNP_007442.1. NC_001808.1.

    Genome annotation databases

    GeneIDi808102.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07726 Genomic DNA. Translation: CAA69015.1 .
    RefSeqi NP_007442.1. NC_001808.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 808102.

    Organism-specific databases

    CTDi 4538.

    Phylogenomic databases

    HOVERGENi HBG093667.

    Family and domain databases

    InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01437. NUOXDRDTASE4.
    TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete mitochondrial DNA sequence of the white rhinoceros, Ceratotherium simum, and comparison with the mtDNA sequence of the Indian rhinoceros, Rhinoceros unicornis."
      Xu X., Arnason U.
      Mol. Phylogenet. Evol. 7:189-194(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiNU4M_CERSI
    AccessioniPrimary (citable) accession number: O03204
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3