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O03204 (NU4M_CERSI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded onMitochondrion
OrganismCeratotherium simum (White rhinoceros) (Square-lipped rhinoceros)
Taxonomic identifier9807 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaRhinocerotidaeCeratotherium

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459NADH-ubiquinone oxidoreductase chain 4
PRO_0000117919

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane95 – 11218Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane145 – 16521Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane284 – 30320Helical; Potential
Transmembrane308 – 33023Helical; Potential
Transmembrane351 – 37121Helical; Potential
Transmembrane391 – 41121Helical; Potential
Transmembrane436 – 45621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O03204 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: F25C961D11EC5DFE

FASTA45951,719
        10         20         30         40         50         60 
MLKIIIPTLM LIPLTWLSKN SMIWINTTAY SLLISFISLP LLSQFNENSL NMSLTFFSDP 

        70         80         90        100        110        120 
LSAPLLVLTT WLLPLMIMAS QHHLSKEPLA RKKLYITMLI TLQTFLIMTF TATELIFFYI 

       130        140        150        160        170        180 
LFEATLIPTL IIITRWGNQT ERLNAGFYFL FYTLTGSLPL LIALTHIQNL TGSLNLLLIQ 

       190        200        210        220        230        240 
YSTQTLPSSW SNAFLWLACM MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAILLKLGG 

       250        260        270        280        290        300 
YGMLRITMIL NPLTSYMAYP FLMLSLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA 

       310        320        330        340        350        360 
VLIQTPWSYM GATALMIAHG LTSSVLFCLA NSNYERTHSR TMILARGLQT LLPLMAMWWL 

       370        380        390        400        410        420 
LASLTNLALP PTINLVGELF VVMSSFSWSN ITIILMGTNI IITALYSLYM LITTQRGKYT 

       430        440        450 
HHINNIKPSF TRENTLMALH LLPLLLLSLN PKIILGTLY 

« Hide

References

[1]"The complete mitochondrial DNA sequence of the white rhinoceros, Ceratotherium simum, and comparison with the mtDNA sequence of the Indian rhinoceros, Rhinoceros unicornis."
Xu X., Arnason U.
Mol. Phylogenet. Evol. 7:189-194(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y07726 Genomic DNA. Translation: CAA69015.1.
RefSeqNP_007442.1. NC_001808.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808102.

Organism-specific databases

CTD4538.

Phylogenomic databases

HOVERGENHBG093667.
ProtClustDBMTH00110.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4M_CERSI
AccessionPrimary (citable) accession number: O03204
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families