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O03173 (NU4M_LATCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded onMitochondrion
OrganismLatimeria chalumnae (West Indian ocean coelacanth) [Reference proteome]
Taxonomic identifier7897 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461NADH-ubiquinone oxidoreductase chain 4
PRO_0000117946

Regions

Transmembrane20 – 4223Helical; Potential
Transmembrane61 – 8121Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane285 – 30420Helical; Potential
Transmembrane309 – 33123Helical; Potential
Transmembrane351 – 37121Helical; Potential
Transmembrane393 – 41321Helical; Potential
Transmembrane436 – 45621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O03173 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 2DEB17101B0AA082

FASTA46152,048
        10         20         30         40         50         60 
MLKVLMPTIM LILTTWLTKP AWLWPTMTTN SLLVATISLT WLKWDSESGW KSLNSSMATD 

        70         80         90        100        110        120 
PLSTPLLILT CWLLPLMILA SQNHMFMEPL NRQRSFISLL ISLQTFLIMA FGATEIILFY 

       130        140        150        160        170        180 
IMFEATLIPT LIIITRWGNQ TERLNAGTYF LFYTVMGSLP LLVALLMTQN NLGTLSMPLI 

       190        200        210        220        230        240 
QHMYQMKLHT HGDMMWWTAC LLAFLVKMPL YGVHLWLPKA HVEAPIAGSM VLAAVLLKLG 

       250        260        270        280        290        300 
GYGMMRLIMM LAPMTKTLAY PFIILALWGI IMTGSICLRQ TDLKSLIAYS SVGHMGLVAA 

       310        320        330        340        350        360 
GILTQTPWGF TGATVLMIAH GLTSSALFCL ANTNYERTHS RTMILARGMQ VILPLMTFWW 

       370        380        390        400        410        420 
LMMNLANLAL PPSTNLMGEL LIITMTFNWS NWTLTMTGLG MLITAIYSLH MFLTTQRGLM 

       430        440        450        460 
TNHIISIEPS HTREHLLMTM HALPMLLLIL KPELIWGWSY X 

« Hide

References

[1]"The complete DNA sequence of the mitochondrial genome of a 'living fossil,' the coelacanth (Latimeria chalumnae)."
Zardoya R., Meyer A.
Genetics 146:995-1010(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U82228 Genomic DNA. Translation: AAC60327.1.
PIRB58893.
RefSeqNP_008338.1. NC_001804.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSLACT00000024867; ENSLACP00000021814; ENSLACG00000022083.
GeneID808092.
KEGGlcm:808092.

Organism-specific databases

CTD4538.

Phylogenomic databases

GeneTreeENSGT00730000111316.
HOVERGENHBG093667.
KOK03881.
OrthoDBEOG7DJSMN.
TreeFamTF343520.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4M_LATCH
AccessionPrimary (citable) accession number: O03173
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families