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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Latimeria chalumnae (West Indian ocean coelacanth)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiLatimeria chalumnae (West Indian ocean coelacanth)
Taxonomic identifieri7897 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
Proteomesi
  • UP000008672 Componentsi: Mitochondrion, Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 42HelicalSequence analysisAdd BLAST23
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei285 – 304HelicalSequence analysisAdd BLAST20
Transmembranei309 – 331HelicalSequence analysisAdd BLAST23
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21
Transmembranei436 – 456HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001179461 – 461NADH-ubiquinone oxidoreductase chain 4Add BLAST461

Interactioni

Protein-protein interaction databases

STRINGi7897.ENSLACP00000021814.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4845. Eukaryota.
COG1008. LUCA.
HOVERGENiHBG093667.
InParanoidiO03173.
KOiK03881.
TreeFamiTF343520.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O03173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKVLMPTIM LILTTWLTKP AWLWPTMTTN SLLVATISLT WLKWDSESGW
60 70 80 90 100
KSLNSSMATD PLSTPLLILT CWLLPLMILA SQNHMFMEPL NRQRSFISLL
110 120 130 140 150
ISLQTFLIMA FGATEIILFY IMFEATLIPT LIIITRWGNQ TERLNAGTYF
160 170 180 190 200
LFYTVMGSLP LLVALLMTQN NLGTLSMPLI QHMYQMKLHT HGDMMWWTAC
210 220 230 240 250
LLAFLVKMPL YGVHLWLPKA HVEAPIAGSM VLAAVLLKLG GYGMMRLIMM
260 270 280 290 300
LAPMTKTLAY PFIILALWGI IMTGSICLRQ TDLKSLIAYS SVGHMGLVAA
310 320 330 340 350
GILTQTPWGF TGATVLMIAH GLTSSALFCL ANTNYERTHS RTMILARGMQ
360 370 380 390 400
VILPLMTFWW LMMNLANLAL PPSTNLMGEL LIITMTFNWS NWTLTMTGLG
410 420 430 440 450
MLITAIYSLH MFLTTQRGLM TNHIISIEPS HTREHLLMTM HALPMLLLIL
460
KPELIWGWSY X
Length:461
Mass (Da):52,048
Last modified:July 1, 1997 - v1
Checksum:i2DEB17101B0AA082
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82228 Genomic DNA. Translation: AAC60327.1.
PIRiB58893.
RefSeqiNP_008338.1. NC_001804.1.

Genome annotation databases

GeneIDi808092.
KEGGilcm:808092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82228 Genomic DNA. Translation: AAC60327.1.
PIRiB58893.
RefSeqiNP_008338.1. NC_001804.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7897.ENSLACP00000021814.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808092.
KEGGilcm:808092.

Organism-specific databases

CTDi4538.

Phylogenomic databases

eggNOGiKOG4845. Eukaryota.
COG1008. LUCA.
HOVERGENiHBG093667.
InParanoidiO03173.
KOiK03881.
TreeFamiTF343520.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU4M_LATCH
AccessioniPrimary (citable) accession number: O03173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.