Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O03173

- NU4M_LATCH

UniProt

O03173 - NU4M_LATCH

Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Latimeria chalumnae (West Indian ocean coelacanth)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
    Alternative name(s):
    NADH dehydrogenase subunit 4
    Gene namesi
    Name:MT-ND4
    Synonyms:MTND4, NADH4, ND4
    Encoded oniMitochondrion
    OrganismiLatimeria chalumnae (West Indian ocean coelacanth)
    Taxonomic identifieri7897 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
    ProteomesiUP000008672: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461NADH-ubiquinone oxidoreductase chain 4PRO_0000117946Add
    BLAST

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei285 – 30420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei309 – 33123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei393 – 41321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei436 – 45621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 4 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00730000111316.
    HOVERGENiHBG093667.
    KOiK03881.
    OrthoDBiEOG7DJSMN.
    TreeFamiTF343520.

    Family and domain databases

    InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view]
    PRINTSiPR01437. NUOXDRDTASE4.
    TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O03173-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKVLMPTIM LILTTWLTKP AWLWPTMTTN SLLVATISLT WLKWDSESGW    50
    KSLNSSMATD PLSTPLLILT CWLLPLMILA SQNHMFMEPL NRQRSFISLL 100
    ISLQTFLIMA FGATEIILFY IMFEATLIPT LIIITRWGNQ TERLNAGTYF 150
    LFYTVMGSLP LLVALLMTQN NLGTLSMPLI QHMYQMKLHT HGDMMWWTAC 200
    LLAFLVKMPL YGVHLWLPKA HVEAPIAGSM VLAAVLLKLG GYGMMRLIMM 250
    LAPMTKTLAY PFIILALWGI IMTGSICLRQ TDLKSLIAYS SVGHMGLVAA 300
    GILTQTPWGF TGATVLMIAH GLTSSALFCL ANTNYERTHS RTMILARGMQ 350
    VILPLMTFWW LMMNLANLAL PPSTNLMGEL LIITMTFNWS NWTLTMTGLG 400
    MLITAIYSLH MFLTTQRGLM TNHIISIEPS HTREHLLMTM HALPMLLLIL 450
    KPELIWGWSY X 461
    Length:461
    Mass (Da):52,048
    Last modified:July 1, 1997 - v1
    Checksum:i2DEB17101B0AA082
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82228 Genomic DNA. Translation: AAC60327.1.
    PIRiB58893.
    RefSeqiNP_008338.1. NC_001804.1.

    Genome annotation databases

    EnsembliENSLACT00000024867; ENSLACP00000021814; ENSLACG00000022083.
    GeneIDi808092.
    KEGGilcm:808092.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82228 Genomic DNA. Translation: AAC60327.1 .
    PIRi B58893.
    RefSeqi NP_008338.1. NC_001804.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSLACT00000024867 ; ENSLACP00000021814 ; ENSLACG00000022083 .
    GeneIDi 808092.
    KEGGi lcm:808092.

    Organism-specific databases

    CTDi 4538.

    Phylogenomic databases

    GeneTreei ENSGT00730000111316.
    HOVERGENi HBG093667.
    KOi K03881.
    OrthoDBi EOG7DJSMN.
    TreeFami TF343520.

    Family and domain databases

    InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01437. NUOXDRDTASE4.
    TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the mitochondrial genome of a 'living fossil,' the coelacanth (Latimeria chalumnae)."
      Zardoya R., Meyer A.
      Genetics 146:995-1010(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiNU4M_LATCH
    AccessioniPrimary (citable) accession number: O03173
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3