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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Latimeria chalumnae (West Indian ocean coelacanth)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiLatimeria chalumnae (West Indian ocean coelacanth)
Taxonomic identifieri7897 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
ProteomesiUP000008672 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4223HelicalSequence AnalysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence AnalysisAdd
BLAST
Transmembranei285 – 30420HelicalSequence AnalysisAdd
BLAST
Transmembranei309 – 33123HelicalSequence AnalysisAdd
BLAST
Transmembranei351 – 37121HelicalSequence AnalysisAdd
BLAST
Transmembranei393 – 41321HelicalSequence AnalysisAdd
BLAST
Transmembranei436 – 45621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461NADH-ubiquinone oxidoreductase chain 4PRO_0000117946Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG093667.
InParanoidiO03173.
KOiK03881.
OrthoDBiEOG7DJSMN.
TreeFamiTF343520.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O03173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKVLMPTIM LILTTWLTKP AWLWPTMTTN SLLVATISLT WLKWDSESGW
60 70 80 90 100
KSLNSSMATD PLSTPLLILT CWLLPLMILA SQNHMFMEPL NRQRSFISLL
110 120 130 140 150
ISLQTFLIMA FGATEIILFY IMFEATLIPT LIIITRWGNQ TERLNAGTYF
160 170 180 190 200
LFYTVMGSLP LLVALLMTQN NLGTLSMPLI QHMYQMKLHT HGDMMWWTAC
210 220 230 240 250
LLAFLVKMPL YGVHLWLPKA HVEAPIAGSM VLAAVLLKLG GYGMMRLIMM
260 270 280 290 300
LAPMTKTLAY PFIILALWGI IMTGSICLRQ TDLKSLIAYS SVGHMGLVAA
310 320 330 340 350
GILTQTPWGF TGATVLMIAH GLTSSALFCL ANTNYERTHS RTMILARGMQ
360 370 380 390 400
VILPLMTFWW LMMNLANLAL PPSTNLMGEL LIITMTFNWS NWTLTMTGLG
410 420 430 440 450
MLITAIYSLH MFLTTQRGLM TNHIISIEPS HTREHLLMTM HALPMLLLIL
460
KPELIWGWSY X
Length:461
Mass (Da):52,048
Last modified:July 1, 1997 - v1
Checksum:i2DEB17101B0AA082
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82228 Genomic DNA. Translation: AAC60327.1.
PIRiB58893.
RefSeqiNP_008338.1. NC_001804.1.

Genome annotation databases

GeneIDi808092.
KEGGilcm:808092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82228 Genomic DNA. Translation: AAC60327.1.
PIRiB58893.
RefSeqiNP_008338.1. NC_001804.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi808092.
KEGGilcm:808092.

Organism-specific databases

CTDi4538.

Phylogenomic databases

HOVERGENiHBG093667.
InParanoidiO03173.
KOiK03881.
OrthoDBiEOG7DJSMN.
TreeFamiTF343520.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete DNA sequence of the mitochondrial genome of a 'living fossil,' the coelacanth (Latimeria chalumnae)."
    Zardoya R., Meyer A.
    Genetics 146:995-1010(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNU4M_LATCH
AccessioniPrimary (citable) accession number: O03173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: April 1, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.