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O03173

- NU4M_LATCH

UniProt

O03173 - NU4M_LATCH

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Protein
NADH-ubiquinone oxidoreductase chain 4
Gene
MT-ND4, MTND4, NADH4, ND4
Organism
Latimeria chalumnae (West Indian ocean coelacanth)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiLatimeria chalumnae (West Indian ocean coelacanth)
Taxonomic identifieri7897 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
ProteomesiUP000008672: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4223Helical; Reviewed prediction
Add
BLAST
Transmembranei61 – 8121Helical; Reviewed prediction
Add
BLAST
Transmembranei93 – 11321Helical; Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Reviewed prediction
Add
BLAST
Transmembranei147 – 16721Helical; Reviewed prediction
Add
BLAST
Transmembranei197 – 21721Helical; Reviewed prediction
Add
BLAST
Transmembranei225 – 24521Helical; Reviewed prediction
Add
BLAST
Transmembranei258 – 27821Helical; Reviewed prediction
Add
BLAST
Transmembranei285 – 30420Helical; Reviewed prediction
Add
BLAST
Transmembranei309 – 33123Helical; Reviewed prediction
Add
BLAST
Transmembranei351 – 37121Helical; Reviewed prediction
Add
BLAST
Transmembranei393 – 41321Helical; Reviewed prediction
Add
BLAST
Transmembranei436 – 45621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461NADH-ubiquinone oxidoreductase chain 4
PRO_0000117946Add
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000111316.
HOVERGENiHBG093667.
KOiK03881.
OrthoDBiEOG7DJSMN.
TreeFamiTF343520.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

O03173-1 [UniParc]FASTAAdd to Basket

« Hide

MLKVLMPTIM LILTTWLTKP AWLWPTMTTN SLLVATISLT WLKWDSESGW    50
KSLNSSMATD PLSTPLLILT CWLLPLMILA SQNHMFMEPL NRQRSFISLL 100
ISLQTFLIMA FGATEIILFY IMFEATLIPT LIIITRWGNQ TERLNAGTYF 150
LFYTVMGSLP LLVALLMTQN NLGTLSMPLI QHMYQMKLHT HGDMMWWTAC 200
LLAFLVKMPL YGVHLWLPKA HVEAPIAGSM VLAAVLLKLG GYGMMRLIMM 250
LAPMTKTLAY PFIILALWGI IMTGSICLRQ TDLKSLIAYS SVGHMGLVAA 300
GILTQTPWGF TGATVLMIAH GLTSSALFCL ANTNYERTHS RTMILARGMQ 350
VILPLMTFWW LMMNLANLAL PPSTNLMGEL LIITMTFNWS NWTLTMTGLG 400
MLITAIYSLH MFLTTQRGLM TNHIISIEPS HTREHLLMTM HALPMLLLIL 450
KPELIWGWSY X 461
Length:461
Mass (Da):52,048
Last modified:July 1, 1997 - v1
Checksum:i2DEB17101B0AA082
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82228 Genomic DNA. Translation: AAC60327.1.
PIRiB58893.
RefSeqiNP_008338.1. NC_001804.1.

Genome annotation databases

EnsembliENSLACT00000024867; ENSLACP00000021814; ENSLACG00000022083.
GeneIDi808092.
KEGGilcm:808092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82228 Genomic DNA. Translation: AAC60327.1 .
PIRi B58893.
RefSeqi NP_008338.1. NC_001804.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSLACT00000024867 ; ENSLACP00000021814 ; ENSLACG00000022083 .
GeneIDi 808092.
KEGGi lcm:808092.

Organism-specific databases

CTDi 4538.

Phylogenomic databases

GeneTreei ENSGT00730000111316.
HOVERGENi HBG093667.
KOi K03881.
OrthoDBi EOG7DJSMN.
TreeFami TF343520.

Family and domain databases

InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view ]
PRINTSi PR01437. NUOXDRDTASE4.
TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the mitochondrial genome of a 'living fossil,' the coelacanth (Latimeria chalumnae)."
    Zardoya R., Meyer A.
    Genetics 146:995-1010(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNU4M_LATCH
AccessioniPrimary (citable) accession number: O03173
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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