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O03170 (COX3_LATCH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded onMitochondrion
OrganismLatimeria chalumnae (West Indian ocean coelacanth) [Reference proteome]
Taxonomic identifier7897 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Cytochrome c oxidase subunit 3
PRO_0000183796

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane31 – 5121Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane239 – 25921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O03170 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: A8EF6F296C26EC11

FASTA26129,694
        10         20         30         40         50         60 
MAHQAHAYHM VDPSPWPITG ATAALLVTSG LAAWFHFNSM ILILMGLTLL LLTMYQWWRD 

        70         80         90        100        110        120 
IIRESTFQGH HTLPVQKSLR YGMILFITSE VFFFLGFFWA FYHSSLAPTP ELGGLWPPTG 

       130        140        150        160        170        180 
ITPLDPFEVP LLNTAVLLAS GITVTWAHHS LMEGQRKEAI QSLFITVLLG LYFTALQATE 

       190        200        210        220        230        240 
YYESPFTIAD GAYGSTFFVA TGFHGLHVII GSTFLIVCLV RQTQYHFTSN HHFGFEAAAW 

       250        260 
YWHFVDVVWL FLYVSIYWWG S 

« Hide

References

[1]"The complete DNA sequence of the mitochondrial genome of a 'living fossil,' the coelacanth (Latimeria chalumnae)."
Zardoya R., Meyer A.
Genetics 146:995-1010(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U82228 Genomic DNA. Translation: AAC60324.1.
PIRG58892.
RefSeqNP_008335.1. NC_001804.1.

3D structure databases

ProteinModelPortalO03170.
SMRO03170. Positions 1-261.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSLACT00000024862; ENSLACP00000021811; ENSLACG00000022078.
GeneID808089.
KEGGlcm:808089.

Organism-specific databases

CTD4514.

Phylogenomic databases

GeneTreeENSGT00390000013064.
HOVERGENHBG016686.
KOK02262.
OMAFFWAFYH.
OrthoDBEOG72VH70.
ProtClustDBMTH00189.
TreeFamTF343435.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_LATCH
AccessionPrimary (citable) accession number: O03170
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families