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O03170

- COX3_LATCH

UniProt

O03170 - COX3_LATCH

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Protein

Cytochrome c oxidase subunit 3

Gene
MT-CO3, COIII, COXIII, MTCO3
Organism
Latimeria chalumnae (West Indian ocean coelacanth)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded oniMitochondrion
OrganismiLatimeria chalumnae (West Indian ocean coelacanth)
Taxonomic identifieri7897 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
ProteomesiUP000008672: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed predictionAdd
BLAST
Transmembranei31 – 5121Helical; Reviewed predictionAdd
BLAST
Transmembranei81 – 10121Helical; Reviewed predictionAdd
BLAST
Transmembranei127 – 14721Helical; Reviewed predictionAdd
BLAST
Transmembranei159 – 17921Helical; Reviewed predictionAdd
BLAST
Transmembranei197 – 21721Helical; Reviewed predictionAdd
BLAST
Transmembranei239 – 25921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Cytochrome c oxidase subunit 3PRO_0000183796Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO03170.
SMRiO03170. Positions 1-261.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000013064.
HOVERGENiHBG016686.
KOiK02262.
OMAiYFVPGPS.
OrthoDBiEOG72VH70.
TreeFamiTF343435.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O03170-1 [UniParc]FASTAAdd to Basket

« Hide

MAHQAHAYHM VDPSPWPITG ATAALLVTSG LAAWFHFNSM ILILMGLTLL    50
LLTMYQWWRD IIRESTFQGH HTLPVQKSLR YGMILFITSE VFFFLGFFWA 100
FYHSSLAPTP ELGGLWPPTG ITPLDPFEVP LLNTAVLLAS GITVTWAHHS 150
LMEGQRKEAI QSLFITVLLG LYFTALQATE YYESPFTIAD GAYGSTFFVA 200
TGFHGLHVII GSTFLIVCLV RQTQYHFTSN HHFGFEAAAW YWHFVDVVWL 250
FLYVSIYWWG S 261
Length:261
Mass (Da):29,694
Last modified:July 1, 1997 - v1
Checksum:iA8EF6F296C26EC11
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82228 Genomic DNA. Translation: AAC60324.1.
PIRiG58892.
RefSeqiNP_008335.1. NC_001804.1.

Genome annotation databases

EnsembliENSLACT00000024862; ENSLACP00000021811; ENSLACG00000022078.
GeneIDi808089.
KEGGilcm:808089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82228 Genomic DNA. Translation: AAC60324.1 .
PIRi G58892.
RefSeqi NP_008335.1. NC_001804.1.

3D structure databases

ProteinModelPortali O03170.
SMRi O03170. Positions 1-261.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSLACT00000024862 ; ENSLACP00000021811 ; ENSLACG00000022078 .
GeneIDi 808089.
KEGGi lcm:808089.

Organism-specific databases

CTDi 4514.

Phylogenomic databases

GeneTreei ENSGT00390000013064.
HOVERGENi HBG016686.
KOi K02262.
OMAi YFVPGPS.
OrthoDBi EOG72VH70.
TreeFami TF343435.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the mitochondrial genome of a 'living fossil,' the coelacanth (Latimeria chalumnae)."
    Zardoya R., Meyer A.
    Genetics 146:995-1010(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCOX3_LATCH
AccessioniPrimary (citable) accession number: O03170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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